U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 12461 - 12470 of 13362 results

Status:
Possibly Marketed Outside US
Source:
NCT01990807: Phase 4 Interventional Unknown status Childhood Acute Lymphoblastic Leukemia
(2012)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Disodium iminodiacetate is a salt of iminodiacetic acid (IDA). The iminodiacetate anion can act as a tridentate ligand to form a metal complex with two, fused, five-membered chelate rings. Iminodiacetic acid is used to diagnose problems of the liver, gallbladder and bile ducts in an imaging procedure, called as hepatobiliary iminodiacetic acid (HIDA) scan. A nuclear medicine scanner tracks the flow of the tracer from the liver into the gallbladder and small intestine and creates computer images. In addition, iminodiacetate is a part of the iminodiacetate-modified poly-L-lysine dendrimer (IMPLD), a fluorescent bone-imaging agent. IMPLD is used in the diagnosis of bone tumors, or to be used for the delivery of chemotherapy drugs or therapeutic agents. Bones differ from other body tissues in their unique calcium mineral composition, which consists mainly of hydroxyapatite (HA). IDA functionalization could be used as a general approach to bone targeting by increasing affinity for HA, enabling the transport of other molecules or particles to bones.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)



Fasudil is a potent Rho kinase inhibitor, which was developed by Asahi Kasei. The drug is used in Asia for the prevention of cerebral vasospasm in patients with subarachnoid hemorrhage.
Status:
Possibly Marketed Outside US
Source:
NCT02847091: Phase 4 Interventional Completed Type 2 Diabetes Mellitus
(2016)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Ipragliflozin L-proline is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It was developed and marketed as Suglat® by Astellas cooperating with Kotobuki Pharmaceutical and Merck Sharp & Dohme, and approved by Pharmaceuticals and Medical Devices Agency of Japan (PMDA) on Jan 17, 2014. It is indicated for the treatment of type 2 diabetes.
Status:
Possibly Marketed Outside US
Source:
DEBERZA by Chugai Pharmaceutical
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Tofogliflozin is a SGLT2 selective inhibitor which was developed by Chugai Pharmaceutical for the treatment of Type 2 Diabetes Mellitus. The drug was approved in Japan in 2013 and it is being marketed under the names Apleway and Debereza.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (RACEMIC)

Enibomal (narcobarbital) is a barbiturate drug. By its chemical structure, it is N-methylated derivative of propallynolal. Narcobarbital was discovered in 1930s and later investigated as an anesthetic agent in gynecological surgery and electroconvulsive treatment. In the United States, narcobarbital is classified as a schedule III drug and is not found in pharmaceutical preparations. In Europe, narcobarbital was used in veterinary as a general anesthetic for pigs, but by 2000 it was withdrawn and no longer available at the market.
Status:
Possibly Marketed Outside US
Source:
Canada:SYMCLOSENE
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Trichloroisocyanuric acid (1,3,5-trichloro-1,3,5-triazine-2,4,6(1H,3H,5H)-tri-one or TCCA) is an N-halo compound which has been known since 1902. It has been used primarily as a disinfectant in swimming pools and water treatment as bleaching agent and bactericide. Recently, TCCA has become attractive candidate as a homogeneous catalyst in organic transformations due to its lack of volatility, commercial availability, low cost and ease of handling. And is also used as a bleaching agent in the textile industry
Status:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Cholinergic anthelmintic, Thenium is used against dog and cat hookworms.
Pyridoxamine (PM) is one of three natural forms of vitamin B6. It is a critical transient intermediate in catalysis of transamination reactions by vitamin B6-dependent enzymes. In preclinical or clinical trials PM has demonstrated pharmacological potential for treatment of diabetic nephropathy, diabetic retinopathy, and hyperlipidemia, and for use in kidney stone preventive therapies. Although its precise mode of action in vivo is not yet clear, it is likely that at least three mechanisms are at play: inhibition of post-Amadori steps of the Maillard reaction; scavenging of reactive carbonyl compounds; and inhibition of toxic effects of ROS. Pyridoxamine was marketed as a dietary supplement, often as the hydrochloride salt, pyridoxamine dihydrochloride. However, in the United States, the FDA ruled in January 2009 that pyridoxamine must be regulated as a pharmaceutical drug because it is the active ingredient in Pyridorin, a drug designed to prevent the progression of diabetic nephropathy.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Sodium Antimonate is Sodium salt of antimonic acid. Sodium Antimonate is used in the Glass Industry as a fining agent or degasser, especially in colour television bulbs and optical glass. Sodium Antimonate is a fire retardant with very low tinting characteristics. As such it is used in plastics, paints, fibre glass resins and various textile goods.
Status:
Possibly Marketed Outside US
Source:
Canada:NITROBENZENE
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Showing 12461 - 12470 of 13362 results