Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C4H5NO4.2Na |
| Molecular Weight | 177.0663 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[Na+].[O-]C(=O)CNCC([O-])=O
InChI
InChIKey=HAXVIVNBOQIMTE-UHFFFAOYSA-L
InChI=1S/C4H7NO4.2Na/c6-3(7)1-5-2-4(8)9;;/h5H,1-2H2,(H,6,7)(H,8,9);;/q;2*+1/p-2
Disodium iminodiacetate is a salt of iminodiacetic acid (IDA). The iminodiacetate anion can act as a tridentate ligand to form a metal complex with two, fused, five-membered chelate rings. Iminodiacetic acid is used to diagnose problems of the liver, gallbladder and bile ducts in an imaging procedure, called as hepatobiliary iminodiacetic acid (HIDA) scan. A nuclear medicine scanner tracks the flow of the tracer from the liver into the gallbladder and small intestine and creates computer images. In addition, iminodiacetate is a part of the iminodiacetate-modified poly-L-lysine dendrimer (IMPLD), a fluorescent bone-imaging agent. IMPLD is used in the diagnosis of bone tumors, or to be used for the delivery of chemotherapy drugs or therapeutic agents. Bones differ from other body tissues in their unique calcium mineral composition, which consists mainly of hydroxyapatite (HA). IDA functionalization could be used as a general approach to bone targeting by increasing affinity for HA, enabling the transport of other molecules or particles to bones.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Application of MCR: facile one-pot diastereoselective syntheses of novel chiral alpha,alpha'-iminodiacetic acid analogues. | 2003 |
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| A novel series of complexones with bis- or biazole structure as mixed ligands of paramagnetic contrast agents for MRI. | 2003 Dec 1 |
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| Electrochemiluminescent biosensors array for the concomitant detection of choline, glucose, glutamate, lactate, lysine and urate. | 2003 Dec 30 |
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| Development and characterization of simulant pancreatic islets. | 2003 Mar 1 |
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| The influence of short strong hydrogen bonding on the structure and the physicochemical properties of alkyl-N-iminodiacetic acids in solid state and aqueous systems. | 2003 Mar 26 |
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| Optimization of immobilized metal ion affinity chromatography for single-step purification of recombinant ovine growth hormone expressed in Escherichia coli. | 2003 May 23 |
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| Analysis of protein adsorption on regenerated cellulose-based immobilized copper ion affinity membranes. | 2003 May 9 |
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| Nucleic acid separations utilizing immobilized metal affinity chromatography. | 2003 May-Jun |
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| Efficient inclusion body processing using chemical extraction and high gradient magnetic fishing. | 2003 May-Jun |
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| Immobilized metal-ion chelating capillary microreactor for peptide mapping analysis of proteins by matrix assisted laser desorption/ ionization-time of flight-mass spectrometry. | 2003 Nov |
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| Cd(II) sensing in water using novel aromatic iminodiacetate based fluorescent chemosensors. | 2003 Oct 30 |
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| Synthesis of a pyridinium bis[citrato(2-)]oxochromate(V) complex and its ligand-exchange reactions. | 2003 Oct 6 |
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| Biological and photochemical degradation rates of diethylenetriaminepentaacetic acid (DTPA) in the presence and absence of Fe(III). | 2004 Apr |
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| Hexafluoroacetone as protecting and activating reagent: site-selective functionalization of iminodiacetic acid. | 2004 Dec |
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| Alternative quality control for technetium-99m IDA complexes. | 2004 Dec |
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| Control of peptide structure and recognition by Fe(III)-induced helix destabilization. | 2004 Dec 8 |
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| Therapeutic efficacy of laparoscopic cholecystectomy in the treatment of biliary dyskinesia. | 2004 Feb |
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| Modelling of the acid-base properties of natural and synthetic adsorbent materials used for heavy metal removal from aqueous solutions. | 2004 Feb |
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| Cleavage of double stranded plasmid DNA by lanthanide complexes. | 2004 Feb 5 |
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| Performance evaluation of two chelating ion-exchange sorbents for the fractionation of labile and inert metal species from aquatic media. | 2004 Jan |
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| Ion exchange properties of monolithic and particle type iminodiacetic acid modified silica. | 2004 Jul |
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| Immobilization of oriented protein molecules on poly(ethylene glycol)-coated Si(111). | 2004 Jul |
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| Solution-phase combinatorial synthesis of nonpeptide bradykinin antagonists. | 2004 Jul 1 |
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| Single-step formation of a biorecognition layer for assaying histidine-tagged proteins. | 2004 Jul 15 |
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| Polystyrene monolithic column functionalized with copper-iminodiacetate complex as a stationary phase for open tubular capillary electrochromatography. | 2004 Jul 30 |
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| Equilibrium-based sampler for determining Cu2+ concentrations in aquatic ecosystems. | 2004 Jun 15 |
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| Preparation of an iminodiacetic acid-modified capillary and its performance in capillary liquid chromatography and immobilized metal chelate affinity capillary electrophoresis. | 2004 Jun 18 |
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| Polyvalent carbocyanine molecular beacons for molecular recognitions. | 2004 Jun 30 |
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| Contributions of commercial sorbents to the selectivity in immobilized metal affinity chromatography with Cu(II). | 2004 Mar 26 |
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| Analysis of myoglobin adsorption to Cu(II)-IDA and Ni(II)-IDA functionalized Langmuir monolayers by grazing incidence neutron and X-ray techniques. | 2004 Mar 30 |
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| Chemical extraction and direct adsorptive purification of recombinant human antigen Ro52. | 2004 May |
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| A single-step chromatographic method for the purification of proteins devoid of exposed histidine residues. | 2004 May |
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| Paramagnetic NMR study of Cu(2+)-IDA complex localization on a protein surface and its application to elucidate long distance information. | 2004 May 21 |
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| A new bis(3-hydroxy-4-pyridinone)-IDA derivative as a potential therapeutic chelating agent. Synthesis, metal-complexation and biological assays. | 2004 Nov 7 |
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| Isolation and growth characteristics of an EDTA-degrading member of the alpha-subclass of Proteobacteria. | 2004 Oct |
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| High-buffering capacity, hydrolytically stable, low-pI isoelectric membranes for isoelectric trapping separations. | 2004 Oct |
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| Purification and identification of water-soluble phosphopeptides from cheese using Fe(III) affinity chromatography and mass spectrometry. | 2004 Oct 20 |
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| Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid. | 2004 Sep 3 |
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| Protein surface-assisted enhancement in the binding affinity of an inhibitor for recombinant human carbonic anhydrase-II. | 2004 Sep 8 |
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| Purification of a catalase from Thermus thermophilus via IMAC chromatography: effect of the support. | 2004 Sep-Oct |
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| Measurement of Wee kinase activity. | 2005 |
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| Arsenic speciation in water samples containing high levels of copper: removal of copper interference affecting arsine generation by continuous flow solid phase chelation. | 2005 Apr |
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| Dense monolayers of metal-chelating ligands covalently attached to carbon electrodes electrochemically and their useful application in affinity binding of histidine-tagged proteins. | 2005 Apr 12 |
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| Phosphoproteomic analysis using immobilized metal ion affinity chromatography on the basis of cellulose powder. | 2005 Jan |
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| Aqua(2,2'-bi-1H-imidazole)chlorocopper(II) chloro(iminodiacetato)copper(II) monohydrate. | 2005 Jan |
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| Speciation of chromium(III) and cobalt(III) (amino)carboxylate complexes using capillary electrophoresis. | 2005 Jan 1 |
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| Multivalent carbocyanine molecular probes: synthesis and applications. | 2005 Jan-Feb |
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| A luminescent receptor with affinity for N-terminal histidine in peptides in aqueous solution. | 2005 Mar 16 |
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| Spacer-based selectivity in the binding of "two-prong" ligands to recombinant human carbonic anhydrase I. | 2005 Mar 8 |
|
| Cooperation of metal-ion fixation and target-site activation for efficient site-selective RNA scission. | 2005 May |
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13575
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213-181-8
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Q2K1N8RVKE
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147496
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PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
