Dobupride is a substituted benzamide drug, which has shown powerful gastroprokinetic activity in animal studies, inducing gastric emptying and intestinal motility and increasing the resting pressure of the lower oesophageal sphincter. Compared with metoclopramide, both drugs increased stomach emptying of liquid and also increased the lower oesophageal sphincter pressure, but after metoclopramide administration more adverse effects (such as anxiety, drowsiness, and sweating) were reported.

Doconazole is the antifungal agent. It is the first of the dioxolane series, which was later to produce ketoconazole, to appear as a potential drug. Antifungal activity of doconazole was compared with miconazole and amphotericin B activity against a number of pathogenic filamentous fungi. Doconazole was found to be more active than miconazole only against Coccidioides immitis and less active against A.fumigatus, B. dermatitidis, H.capsulatum and S.schenckii. Doconazole has been described as the drug of choice for oral treatment of murine coccidioidomycosis but was dropped because it produced glaucoma in dogs. Doconazole is used for the treatment of infections of the skin and mucous membranes caused by the Herpes simplex type 1 virus, including herpes of lips. Docosanol affects the fusion of the virus with the plasma membrane, which inhibits the penetration of the virus into the cell and its subsequent replication. Side effects are: dry skin, pruritus, rash, short-term redness, soreness, peeling, burning or tingling.

Hydromadinone is a steroidal progestin that has never been marketed.

Anisperimus [LF 150195] is a deoxyspergualin analogue under development by Fournier Pharma (formerly Groupe Fournier) for the potential treatment of autoimmune disorders and transplant rejection. Anisperimus is a more potent, and less toxic analogue of 15-deoxyspergualin, an antibiotic used as an immunosuppressive agent to prevent rejection of organ transplants. Anisperimus enhances activation-induced T-cell death by facilitating caspase-8 and caspase-10 activation at the DISC level. Phase I clinical studies were being conducted by Fournier in France for Transplant rejection and Phase II clinical studies for Autoimmune disorders in Europe. However development of anisperimus has been discontinued.

Antazonite (R 6438) is an anthelmintic agent. When given orally to chickens in a dose of 160 mg/Kg body weight, all Ascaridia sp., all Hetevakis sp., and about 30% Capillaria sp. are expelled within 48 hr. It is supposed that the anthelmintic activity of Antazonite is due to its major metabolite, R 8141. R 6438 is active as an anthelmintic in poultry, but not in rats. Its metabolite, R 8141, is active in both species.

Anilopam is an opioid analgesic of the benzazepine class. It is an opioid receptor agonist.

Supidimide is a benzisothiazol derivative patented by Chemie Gruenenthal G.m.b.H. as a sedative and hypnotic agent. Supidimide acts as serotonin release inhibitor and decreases of 5-HT release into the synaptic cleft in preclinical studies. In clinical trials, Supidimide substantially relieved sleep disturbances in schizophrenic inpatients. Besides that Supidimide administration associated with a decrease in "somatic concern", items related to agitation, "irritability" and "manifest psychosis", and a slight increase in "retardation".