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Status:
Investigational
Source:
NCT00002403: Phase 1 Interventional Completed HIV Infections
Source URL:
Class:
NUCLEIC ACID
Status:
Investigational
Source:
NCT00642018: Phase 2 Interventional Completed Prostate Cancer
(2008)
Source URL:
Class:
NUCLEIC ACID
Status:
Investigational
Source:
NCT01065935: Phase 2 Interventional Completed Respiratory Syncytial Virus Infections
(2010)
Source URL:
Class:
NUCLEIC ACID
Status:
Investigational
Source:
NCT00306904: Phase 2 Interventional Completed Diabetic Macular Edema
(2006)
Source URL:
Class:
NUCLEIC ACID
Status:
Investigational
Source:
NCT00042081: Phase 3 Interventional Completed Coronary Artery Disease
(2002)
Source URL:
Class:
NUCLEIC ACID
Status:
Investigational
Source:
USAN:Omafilcon A [USAN]
Source URL:
Class:
POLYMER
Status:
Investigational
Source:
USAN:NARAFILCON B [USAN]
Source URL:
Class:
POLYMER
Status:
Investigational
Source:
NCT01943162: Not Applicable Interventional Completed PTSD With a History of Mild to Moderate TBI
(2012)
Source URL:
Class:
POLYMER
Conditions:
Mureletecan is a water-soluble prodrug, consisting of camptothecin covalently linked to polymeric backbone methacryloylglycynamide, with potential antineoplastic activity. After entering tumor cells, the active moiety camptothecin is slowly released from mureletecan via hydrolysis of the ester linkage. Camptothecin, the active moiety, is an alkaloid isolatable from the Chinese tree Camptotheca acuminata. Camptothecin itself suffers from poor solubility, which is why it is often investigated with a solubilizing conjugate; such as in Mureletecan. Camptothecin binds to and stabilizes the topoisomerase I-DNA covalent complex producing potentially lethal double-stranded DNA breaks when encountered by DNA replication machinery. Camptothecin has also been shown to inhibit HIF1a. Camptothecin has been investigated with a number of solubilizing conjugates as a potential treatment in various forms of cancer.
Status:
Investigational
Source:
USAN:HIOXIFILCON A [USAN]
Source URL:
Class:
POLYMER
Status:
Investigational
Source:
USAN:SENOFILCON A [USAN]
Source URL:
Class:
POLYMER
