U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 831 - 840 of 2596 results

Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Targets:

Conditions:

3,4,5-Trimethoxybenzaldehyde is a key intermediate in the synthesis of trimethoprim[2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine], which, in addition to its antibacterial activity, possesses the property of significantly strengthening the bactericidal activity of sulfanilamide preparations. Also, 3,4,5-Trimethoxybenzaldehyde id used for the synthesis of Isoamoenylin, which showed moderate antioxidative and weak antibacterial activities. An A-ring analogue of colchicine, 3,4,5-trimethoxybenzaldehyde, can stop the antimitotic drug IKP104-induced unfolding of tubulin significantly. 3,4,5-trimethoxybenzaldehyde stimulated tubulin-dependent GTP hydrolysis.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Dibutyl oxalate is used in the manufacture of lubricants is biologically toxic causing neurological degradation characterized by ataxia and stupor. Sufficient dosing of dibutyl oxalate induces oxalate retinopathy, an experimental model of "flecked retina". In this model, the retinal flecks are the result of an intracellular accumulation of calcium oxalate in the RPE cells.
Status:
Other

Class (Stereo):
CHEMICAL (RACEMIC)

Conditions:

There is no information related to the biological and pharmacological properties of the erythro-aleuritic acid, it is known, that this is one of the forms of aleuritic acid, the last is used as a component a component in the perfume industry for the preparation of musk aroma.
Strychnine-N-oxide is the major metabolite of Strychnine. Strychnine, the major alkaloid present in $trychnos:nuxypmicagseeds has been reported to stimulate the entire central nervous system with preference for the spinal cord. It is a powerful convulsant and because of this property, it is an important pharmacological tool as it plays a unique role as an inhibitor of post synaptic inhibitory impulses. It is useful to study inhibitory transmitter and receptor types. However, because of its extreme toxicity, strychnine does not have any therapeutic application in the Western system of medicine. Strychnine-N-oxide is less toxic and less convulsive than strychnine itself. However, strychnine N-oxide is not being used as a therapeutic agent now probably because of the threat of convulsions at higher doses. Strychnine-N-oxide is a muscarinic allosteric agent.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Magnesium propionate is soluble Magnesium salt, that can be used for prevention of hypoglycemia and ketonemia. Administration of magnesium propionate could counteract the hypoglycemia and hyperketonemia induced by tributyrin administration without significantly changing the insulin response
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

MAGNESIUM ASCORBATE/PIDOLATE has a good anti-oxidant activity. It is used in personal care products. For example, as a component of anti-aging mask and in the other cosmetic products.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Manganese Benzoate is inorganic manganese salt with the formula C14H10MnO4. Manganese benzoate can be prepared by dropping sodium benzoate solution into a solution of manganese acetate. Manganese benzoate can be used as antiperspirant cosmetic products.
Status:
Other

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

Mono(ethylhexyl) phthalate (MEHP) is an active metabolite of Bis(2-ethylhexyl)phthalate (DEHP). DEHP is a widely used plasticizer. MEHP has been shown to be moderately toxic. Studies involving orally administered MEHP revealed the mild hepatic changes occurred but there was no bioaccumulation of the monoester. Studies of the rat and rabbit indicated that MEHP has no teratogenic effects. This compound was readily absorbed from the gastrointestinal tract. Radioactivity following intravenous administration of 14C-MEHP was rapidly distributed in tissues, with the highest levels occurring in the liver, kidney, and urinary bladder. Mono(ethylhexyl) phthalate is a member of a class of chemical compounds with known adverse effects on the male reproductive system.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

Taxifolin-7-glucoside is a natural phenolic compound isolated from Picea abies and Allium cepa L.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

Taxifolin-3-glucoside is a natural phenolic compound found in Agrimonia pilosa Ledeb and in the plants of coniferae.