Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C10H12O4 |
| Molecular Weight | 196.1999 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC(C=O)=CC(OC)=C1OC
InChI
InChIKey=OPHQOIGEOHXOGX-UHFFFAOYSA-N
InChI=1S/C10H12O4/c1-12-8-4-7(6-11)5-9(13-2)10(8)14-3/h4-6H,1-3H3
3,4,5-Trimethoxybenzaldehyde is a key intermediate in the synthesis of trimethoprim[2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine], which, in addition to its antibacterial activity, possesses the property of significantly strengthening the bactericidal activity of sulfanilamide preparations. Also, 3,4,5-Trimethoxybenzaldehyde id used for the synthesis of Isoamoenylin, which showed moderate antioxidative and weak antibacterial activities. An A-ring analogue of colchicine, 3,4,5-trimethoxybenzaldehyde, can stop the antimitotic drug IKP104-induced unfolding of tubulin significantly. 3,4,5-trimethoxybenzaldehyde stimulated tubulin-dependent GTP hydrolysis.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents. | 2004 Aug 12 |
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| Two novel series of allocolchicinoids with modified seven membered B-rings: design, synthesis, inhibition of tubulin assembly and cytotoxicity. | 2005 May 16 |
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| (E)-1-(4-Bromo-phen-yl)-3-(3,4,5-trimethoxy-phen-yl)prop-2-en-1-one. | 2008 Dec 13 |
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| Deprotonative magnesation and cadmation of [1,2,3]triazolo[1,5-a]pyridines. | 2009 Jan 2 |
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| Investigation of the antioxidant properties of some new 4-hydroxycoumarin derivatives. | 2009 Jul |
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| (E)-1-[4-(Prop-2-yn-1-yl-oxy)phen-yl]-3-(3,4,5-trimeth-oxy-phen-yl)prop-2-en-1-one. | 2010 Aug 11 |
|
| Enhanced activity of antifungal drugs using natural phenolics against yeast strains of Candida and Cryptococcus. | 2011 May |
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WL86YD76N6
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86-81-7
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6858
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201-701-6
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DTXSID4058948
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3,4,5-Trimethoxybenzaldehyde
Created by
admin on Sat Dec 16 01:38:28 GMT 2023 , Edited by admin on Sat Dec 16 01:38:28 GMT 2023
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SUBSTANCE RECORD
