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Ethyl-2-cyclohexylpropionate is an aroma compound with the fruity smell. It is used as a component of perfumes.
Oxedrine (-)- is an inactive enantiomer of alkaloid oxedrine (synephrine). Oxedrine (-)- was detected in orange juice and marmalade. It may thus possibly be formed during production using citrus fruits. The natural alkaloid synephrine exists only as (+)-synephrine, whereas synthetically produced synephrine exists as a 50/50 racemic mixture of (-)/(+)-synephrine. Following ingestion of (+)-oxedrine, it is postulated that chiral inversion occurs, resulting in inversion to oxedrine (-)- in urine. Epinephrine analogs such as propadrine and oxedrine (-)- counteracted the biological action of epinephrine.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Naftopidil,(R)- is an enantiomer of Naftopidil (NAF), a specific subtype selective α1-adrenoceptor blocker. Racemic Naftopidil is frequently used for the treatment of lower urinary tract symptoms/benign prostatic hyperplasia. No significant differences in pharmacokinetic parameters were observed between R(+)- and S(−)-NAF after intravenous administration. However, mean plasma concentrations of S(−)-NAF were higher than those of R(+)-NAF after intragastric administration. S(−)-NAF reached higher plasma concentrations within shorter times and achieved lower plasma CL within 24 h than R(+)-NAF. S(−)-NAF bioavailability in rats was consistently about two-fold higher than that of R(+)-NAF. The major pathways of S(−)-NAF metabolism in vitro were demethylation and hydroxylation. CYP2C9 played the most important role in the demethylation and hydroxylation of both NAF enantiomers.
Racemic alpha-alkyl-alpha-amino-acids are difficult solutes to resolve on chiral chromatographic phases derived from proline or pipecolic acid-polyacrylamide. The use of L-3-carboxy-1,2,3,4-tetrahydroisoquinoline (L-porretine) as the chiral selector instead of the former alpha-amino-acids selectively resolves the alpha-alkyl-alpha-amino-acids.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
JWH-210 is an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB1 and CB2 receptors. JWH-210 is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higher binding affinity. The physiological and toxicological properties of this compound have not been evaluated in humans.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
I-AB-MECA is iodinated form of parent compound - adenosine derivative, 4-aminobenzyl-5'-N-methylcarboxamidoadenosine (AB-MECA). AB-MECA i a potent agonist of adenosine A3 receptor agonist. 125I-labeled AB-MECA is widely used in in vitro pharmacological studies of adenosine A3 receptor as a refernece ligand. In addition I-AB-MECA is usefull in vitro autoradiography to map adenosine A3 receptor distribution tissues. I-AB-MECA bound to the rat adenosine A1 receptor and canine adenosine A2a receptor.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
GR 103691 is an effective and selective receptor antagonist of the D3DR (dopamine D3 receptor). GR 103691 was shown to have 100-fold higher selectivity for D3DR (dopamine D3 receptor) over the D2DR (dopamine D2 receptor) and D4DR (dopamine D4 receptor) sites. GR 103,691 is functionally active in vivo and will inhibit the hyperactivity response induced by intra-VTA (ventral tegmental area) injection of muscimol in rats.
(6S ,12AS)-Tadalafil is an inactive enantiomer of "Tadalafil" which is the active ingredient in Cialis which is used to treat erectile dysfunction. Tadalafil has 4 isomers [(RR), (SS), (RS), and (SR)], of which (RR) is the name-sake isomer and potent inhibitor of phosphodiesterase-5. The (RS) diastereomer is the only other isomer with some PDE-5 inhibitory activity.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively. Pharmaceutical agents which would prevent the induced expression of one or more of the cell adhesion molecules on the endothelium might be expected to provide a novel mechanism to attenuate the inflammatory responses associated with chronic inflammatory diseases.
(+)-Catechin gallate is a polyphenol, which occurs naturally in grapes, probably in green tea leaves (trace amounts) and other plants.