Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C30H35N3O3 |
| Molecular Weight | 485.6172 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C(C=CC=C1)N2CCN(CCCCNC(=O)C3=CC=C(C=C3)C4=CC=C(C=C4)C(C)=O)CC2
InChI
InChIKey=JARNORYOPMINDY-UHFFFAOYSA-N
InChI=1S/C30H35N3O3/c1-23(34)24-9-11-25(12-10-24)26-13-15-27(16-14-26)30(35)31-17-5-6-18-32-19-21-33(22-20-32)28-7-3-4-8-29(28)36-2/h3-4,7-16H,5-6,17-22H2,1-2H3,(H,31,35)
| Molecular Formula | C30H35N3O3 |
| Molecular Weight | 485.6172 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/12763098 | https://www.ncbi.nlm.nih.gov/pubmed/9765337 | https://www.ncbi.nlm.nih.gov/pubmed/12711089
Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/12763098 | https://www.ncbi.nlm.nih.gov/pubmed/9765337 | https://www.ncbi.nlm.nih.gov/pubmed/12711089
GR 103691 is an effective and selective receptor antagonist of the D3DR (dopamine D3 receptor). GR 103691 was shown to have 100-fold higher selectivity for D3DR (dopamine D3 receptor) over the D2DR (dopamine D2 receptor) and D4DR (dopamine D4 receptor) sites. GR 103,691 is functionally active in vivo and will inhibit the hyperactivity response induced by intra-VTA (ventral tegmental area) injection of muscimol in rats.
Approval Year
Sample Use Guides
Binding studies were carried out at recombinant hD2 receptors and hD3 receptors expressed in CHO cell lines. GR-103691 binding affinities at hD2 and hD3 receptors were determined using [125I]-iodosulpride (0.1 and 0.2 nM for D2 and D3, respectively), [3H]-(1)-S 14297 (7 nM for D3) and [3H]-(1)-PD 128,907 (2 nM for D3). Nonspecific binding was defined using 10 mM raclopride.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:40:06 GMT 2023
by
admin
on
Sat Dec 16 08:40:06 GMT 2023
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| Record UNII |
0Y0CM1A77L
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| Record Status |
Validated (UNII)
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| Record Version |
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0Y0CM1A77L
Created by
admin on Sat Dec 16 08:40:06 GMT 2023 , Edited by admin on Sat Dec 16 08:40:06 GMT 2023
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