U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 451 - 460 of 2596 results

Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

Dehydroergosterol acetate is ergosterol derivative that can be used in photochemical reactions.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

Andrographic acid is isolated from Andrographis paniculata, a traditional Chinese medicine (TCM) that has been effectively used for treatment of infection, inflammation, cold, fever, and diarrhea in China.
(+)-octopamine is an enantiomer of octopamine, a naturally occurring phenolamine acting as a neurotransmitter in invertebrates. Octopamine is considered to be trace amine present in mammalian tissues at very low (nanomolar) concentrations. Generally, the (+)-enantiomers of octopamine are less active than the (-)-enantiomers at adrenergic receptors. However (+)-octopamine is more potent than the (-)-octopamine as an inhibitor of semicarbazide-sensitive amine oxidase.
(-)-octopamine is an enantiomer of octopamine, a naturally occurring phenolamine acting as a neurotransmitter in invertebrates. Octopamine is considered to be trace amine present in mammalian tissues at very low (nanomolar) concentrations. Generally, the (-)-enantiomers of octopamine are more active than the (+)-enantiomers at adrenergic receptors. However (+)-octopamine is more potent than the (-)-octopamine as an inhibitor of semicarbazide-sensitive amine oxidase.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Trans-1,8-terpin compound belongs to the class of organic compounds known as menthane monoterpenoids. 1,8-terpin exists in two geometrical isomeric forms: cis and trans. cis-1,8-terpin is the common form exerting expectorant properties. Pharmacological activity of trans isomer is not available.
Status:
Other

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

A-740003 is a competitive antagonist of P2X purinoceptor 7 (P2X7) that has been shown to potently block proinflammatory cytokine interleukin-1β (IL-1β) release, and also is a promising candidate for the development of a radiotracer for imaging of neuroinflammation by positron emission tomography.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

Valinomycin is an ionophore and acts by creating an influx of K+ ions in bacterial cells. It is an antibiotic substance with wide range of activity against different bacteria, fungies and virus-infected cells. Also it demonstrates insecticide and nematocide properties. Because of its toxicity to eukaryotic cells, valinomycin cannot be used in human therapy.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

Isoquassin also known as picrasmin is the major component of plant extract, quassinoid derived from the wood of tropical tree Picrasma excelsa.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

The (2S,3R) enantiomer in Voriconazole (V760000) drug substance
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

(R)-carvedilol, an enantiomer of the drug carvedilol, which is used in the treatment of mild to moderate congestive heart failure. (R)-carvedilol is an alpha adrenergic receptor blocker. It was shown, that (R)-carvedilol increased sympathetic tone, presumably as a physiological reaction to the decrease in blood pressure caused by alpha-blockade. The weak clinical net effect of beta-blockade of (R, S)-carvedilol at rest might be one reason why this drug causes fewer side effects than other beta-blockers, such as a reduction of nocturnal melatonin release.