(1'S,2'S)-nicotine-1'-N-oxide is a stereoisomer of nicotine-1'-N-oxide, an oxidation product of S-(-)-nicotine. N-1'-oxidation of nicotine is mediated via flavin-containing monooxygenase. A marked stereoselectivity has been observed in the formation of N-1'-oxide metabolites from nicotine. Mammal hepatic preparations generally produce more the N-1'R,2'S-cis diastereoisomer than N-1'S,2'S-trans diastereoisomer after incubation with S-(-)-nicotine. (1'S,2'S)-nicotine-1'-N-oxide was reported to bind alpha3beta4 neuronal nicotinic acetylcholine receptor. cis- and trans-nicotine-N'-oxides modulate the development of tumors in rats initiated with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.

R-7-hydroxywarfarin belongs to the family of Chromones. R-7-Hydroxywarfarin is a metabolite of Warfarin. R-7-Hydroxywarfarin is only found in individuals that have used or taken Warfarin.

SDB-005 is a synthetic cannabinoid. It is considered to be a constituent of illicit smoking mixtures "spice".

5F-SDB-006 is a synthetic cannabinoid. It is considered to be a constituent of illicit smoking mixtures "spice".

There is no much information related to the epiandrosterone sulfate formation but is known, that it is formed during androgen metabolism. It was found significant and sodium-dependent organic anion transporter SOAT (SLC10A6)-mediated transport of epiandrosterone sulfate. In addition, Omics investigation into chronic widespread musculoskeletal pain reveals epiandrosterone sulfate as a potential biomarker.

Androsterone sulfate is endogenous, naturally occurring steroid and the the most abundant 5 alpha-reduced androgen metabolite in serum. This steroid is formed from the reaction of sulfation of androsterone and can be desulfated back by the action of steroid sulfatase. It was also found significant and sodium-dependent organic anion transporter SOAT (SLC10A6)-mediated transport of Androsterone sulfate. There existed assumption that may be this steroid could be a marker of systemic 5 alpha-reductase activity, but that was not confirmed and thus androsterone sulfate cannot take into consideration as a marker of either adrenal androgen production or of hirsutism.

Potassium o-phenolsulfonate is a competitive inhibitor of salicylate hydroxylation under the aerobic conditions, inhibited the salicylate-dependent reduction of FAD under the anaerobic conditions.

CGP60474 is a promising inhibitor of CDK1 with a high degree of selectivity versus other serine/threonine and tyrosine kinases and show competitive kinetics relative to ATP.

(R)-Di-p-Hydroxyphenylpropionitrile (2,3-bis(p-hydroxyphenyl)propionitrile) is an estrogen receptor β (ERβ) selective agonist that exhibits a 100-fold greater relative potency for ERβ in transient reporter gene transcription assays. In vitro binding studies using recombinant rat, ERβ revealed that S- DI-P-Hydroxyphenylpropionitrile has a severalfold greater relative binding affinity for ERβ than does R- DI-P-Hydroxyphenylpropionitrile. Furthermore, cotransfection of N-38 immortalized hypothalamic cells with an estrogen response element-Luc reporter and ERβ revealed that S-DPN is a potent activator of transcription in vitro, whereas R-DI-P-Hydroxyphenylpropionitrile is not. (R)-Di-p-Hydroxyphenylpropionitrile to be a useful probe of the unique biology of ERβ and a pharmacological alternative to analysis of the phenotype of ERβ-knockout animals.

(R)-Lisinopril Sodium Salt is the R,S,S-Isomer of Lisinopril. Lisinopril is a potent inhibitor of angiotensin-converting enzyme (ACE). Lisinopril prevents the conversion of angiotensin I to angiotensin II, which acts as a potent vasoconstrictor and also signals the release of aldosterone, which modulates sodium absorption. ACE inhibition has the net result of vasodilation and increased sodium and water excretion. Lisinopril, (2S)-1-[(2S)-6-amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino] hexanoyl]pyrrole-2-carboxylic acid is an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension, heartfailure andacutemyocardial infarction. The RSS isomer of lisinopril ((2S)-1-[(2S)-6-amino-2-[[(1R)-1-carboxy- 3-phenylpropyl]amino]hexanoyl]pyrrole-2-carboxylic acid) is an impurity (impurity E) resulting from the synthesis of lisinopril. The impurity profile of a drug substance is critical to its safety assessment and is important for monitoring the manufacturing process.