U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 151 - 160 of 2596 results

Status:
Investigational
Source:
INN:risocaine
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

There is no information in the scientific papers related to the biological properties of risocaine (also known as n-propyl 4-aminobenzoate). However, exists mention, that it is used as a local anesthetic.
Status:
Investigational
Source:
NCT03074435: Phase 3 Interventional Completed Malaria
(2016)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Chlorpyrifos (CPF) is a crystalline organophosphate insecticide. It was introduced in 1965 by Dow Chemical Company and is known by many trade names (see table), including Dursban and Lorsban. It acts on the nervous system of insects by inhibiting acetylcholinesterase. Chlorpyrifos is an organophosphate, with potential for both acute toxicity at larger amounts and neurological effects in fetuses and children even at very small amounts. For acute effects, the EPA classifies chlorpyrifos as Class II: moderately toxic. CPF is a strongly genotoxic agent that induces DNA damage and cell apoptosis.
Status:
Investigational
Source:
USAN:IODOANTIPYRINE I 131 [USAN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Iodoantipyrine I-131 is a radiopharmaceutical nonsteroid anti-inflammatory compound evaluated for coronary blood flow measure and as a total body water marker. In vivo results suggested that soon after injection of 4-I131 AP (Iodoantipyrine I-131) in rats , significant and increasing quantities of the I131 tracer were detached from the antipyrine molecule in a form which is more diffusible than 4-I131 AP. Evidence for a similar phenomenon was seen in other species. There were qualitative differences in the behavior of antipyrine and 4-I131 AP when injected in animals, and these may invalidate the use of 4-I131 AP as a substitute for antipyrine in studies of body composition.
Status:
Investigational
Source:
INN:dexpropranolol [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

(R)-(+)-Propranolol (also known as DEXPROPRANOLOL) is the less active enantiomer of propranolol and is an antagonist of the beta-adrenergic receptor. It is known, that propranolol had been used for myocardial infarction; arrhythmia, anxiety and some other disease, but adverse effects instigated the replacement by newer drugs.
Status:
Investigational
Source:
INN:fluretofen [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

There is no information about biological and pharmacological application of Fluretofen also known as 4'-ethynyl-2-fluorobiphenyl. It is known, that it is an anti-inflammatory agent. And its main metabolite 2-fluoro-4'-biphenylyl)acetic acid, also possesses anti-inflammatory activity.
Status:
Investigational
Source:
NCT04673396: Phase 1 Interventional Unknown status Solid Tumor
(2020)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Endothal (also known as Endothall), a herbicide for terrestrial and aquatic plants, is a potent, selective protein phosphatase 2A (PP2A) inhibitor. It also inhibits protein phosphatase 1 (PP1). Endothall is considered safe in drinking water, but in case of consumption for a long period, it can cause stomach or intestinal problems.
Status:
Investigational
Source:
INN:glyoctamide
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Information related to the biological and/or pharmacological activity of glyoctamide is absence. Only one mention exists, describing, that this compound was developed as the antidiabetic agent by Hoechst Roussel Pharm. Inc
Status:
Investigational
Source:
Neurology. Jan 1969;19(1):101-4.: Not Applicable Human clinical trial Completed Multiple Sclerosis/blood
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Androsterone, a neurosteroid, acts as a positive allosteric modulator of GABA(A) receptors, that can cross into the brain and could have effects on brain function. It was discovered, that the association of beta subunits with alpha subunits GABA(A) receptor affects the sensitivity of glycine receptors to androsterone. In spite of that, androsteron is considered as an inactive metabolite of testosterone. In addition, was studied that androsterone possessed anticonvulsant properties. Although of low potency, the androsterone was present in high abundance and was able to represent endogenous modulator of seizure susceptibility.
Status:
Investigational
Source:
Br J Clin Pract. May 1971;25(5):233-5.: Not Applicable Human clinical trial Completed Bronchitis
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Oxotremorine, a metabolite of tremorine, is a non-hydrolyzed muscarinic acetylcholine receptor agonist used as a research tool. This compound is a muscarinic agent equal in potency to acetylcholine, but completely lacking in nicotinic activity.
Status:
Investigational
Source:
USAN:PHENBUTAZONE SODIUM GLYCERATE [USAN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

There is no information about biological and/or pharmacological application of phenbutazone sodium glycerate.