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There is no information related to the pharmacological application of DL-thyroxine, but is known, that this is a mixture of two: L (levothyroxine) and D (dextrothyroxine) forms, and it was shown, that levothyroxine possessed greater antioxidative effect, than the DL.
Simazine is a selective triazine herbicide, that used to control broad-leaved weeds and annual grasses in a field, berry fruit, vegetable and ornamental crops, on turfgrass, and in orchards and vineyards. At higher rates, it is used for nonselective weed control in industrial areas. Before 1992, simazine was used to control submerged weeds and algae in large aquariums, farm ponds, fish hatcheries, swimming pools, ornamental ponds and cooling towers. Simazine is available in wettable powder, water dispersible granule, liquid and granular formulations. Simazine is highly toxic if inhaled, moderately toxic if ingested, and slightly toxic via dermal exposure. No cases of poisoning in humans have been reported from ingestion of Simazine.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
The tetrahydroisoquinoline nucleus is present in a number of compounds and drugs. Tetrahydroisoquinolines (THIQs), which belong to a group of cyclized condensation adducts of biogenic amines with aldehydes, are referred to as mammalian alkaloids. They include salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline; SAL) and tetrahydropapaveroline (6,7-dihydroxy-1-(3',4'-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline; THP) that are derived from dopamine through condensation with acetaldehyde and dopaldehyde (3,4-dihydroxyphenylacetaldehyde), respectively. THP is a putative dopaminergic neurotoxin that is implicated in the pathology of Parkinson's disease. It is known that THP is detected at a high level in the brain and the urine of parkinsonian patients under 3,4-dihydroxyphenylalanine (L-DOPA) therapy. In addition, significant levels of THP have also been detected in the brain after ethanol uptake and/or L-DOPA treatment, and this endogenous alkaloid is considered to account for the neurobehavioral abnormalities associated with alcoholism and may act as a neurotransmitter
7-aminocephalosporanicacid (7-ACA) is convenient starting material for the industrial production of various kinds of semisynthetic cephalosporin antibiotics. In many cases, chemical modifications at the C-7 position is required. Industrially, 7-ACA is derived by chemical or enzymatic deacylation from cephalosporin C, which is fermentatively produced by Acremonium chrysogenum. 7-ACA is a stable only at neutral pHs, enzymatic manipulations are desirable for chemical modifications in the production of cephalosporin related compounds.
Endrin is an organochlorine pesticide used as a non-systemic insecticide, acaricide, and rodenticide for protecting grain. As a central spasmodic agent, endrin is highly toxic to humans and skin resorption is possible. Endrin is rapidly metabolized by animals and does not accumulate in fat to the same extent as other compounds with similar structures. Endrin is also damaging to the liver, kidneys and central nervous system.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
4-Hydroxyestrone (4-OHE1) is a carcinogenic metabolite originating from 17beta-estradiol (17β-E2) hormone. 4-OHE1 was a partial estrogen agonist on cancellous bone turnover, similar to 17β-E2, is able to emit electrons from its excited singlet state. The quantum yield is nearly the same like this of 17β-E2 and decreases with increasing substrate concentration, but enhances with temperature. The 4-OHE1 transient derived from the electron ejection process is leading to the formation of a secondary metabolite by reaction with the present C2H4OH radical. This fact indicates, that depending on the life habits of a person, a variety of metabolites can be formed, also such initiating cancer.
Propyl benzoate, also known as benzoic acid propyl ester, is a naturally-occurring chemical compound found in clove stems and sweet cherries. This organic compound is used in a number of applications. It is characterized by a nutty odor and tastes like a sweet fruit, and hence used as a synthetic flavoring agent in foods. It also has antimicrobial properties and used as a preservative in the cosmetics industry. It is on FDA CFR - Code of Federal Regulations Title 21 list.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Quinic acid is an acid obtained from cinchona bark, coffee beans, tobacco leaves, carrot leaves, apples, etc. For over 50 years, hippuric/quinic acids were believed to have no biological efficacy, but in 2009th these components were identified as major dietary components, and not simply originating from environmental pollution as previously had been thought. Quinic acid has been shown to possess radioprotection, anti-neuroinflammatory, and anti-oxidant activities. It also inhibits the TNF-α-stimulated induction of vascular cell adhesion molecule-1 (VCAM-1) by inhibiting the MAP kinase and NF-κB signaling pathways, which may explain the ability of QA to inhibit vascular inflammation such as atherosclerosis.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Paradichlorobenzene is a chlorinated aromatic hydrocarbon. It is a fumigant insecticide and repellent. Paradichlorobenzene turns directly from a solid into a gas, a process called sublimation. The target organisms are molds, mildews, and insects, but paradichlorobenzene can also be toxic to people and other animals. Most pesticide products containing paradichlorobenzene in the U.S. are used to control clothes moths in airtight containers. Paradichlorobenzene was first registered for use in the United States in 1942, and it is sometimes called 1,4-dichlorobenzene.
2,4,5-trihydroxybutyrophenone is an antioxidant, especially for fats and oils. Potential food packaging migration residue. 2,4,5-trihydroxybutyrophenone is on the FDA Code of Federal Regulations Title 21 list.