1,4-DICHLOROBENZENE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H4Cl2
Molecular Weight	147.002
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC1=CC=C(Cl)C=C1

InChI

InChIKey=OCJBOOLMMGQPQU-UHFFFAOYSA-N

InChI=1S/C6H4Cl2/c7-5-1-2-6(8)4-3-5/h1-4H

HIDE SMILES / InChI

Molecular Formula	C6H4Cl2
Molecular Weight	147.002
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://npic.orst.edu/ingred/pdb.html | http://nj.gov/health/eoh/rtkweb/documents/fs/0643.pdf

Paradichlorobenzene is a chlorinated aromatic hydrocarbon. It is a fumigant insecticide and repellent. Paradichlorobenzene turns directly from a solid into a gas, a process called sublimation. The target organisms are molds, mildews, and insects, but paradichlorobenzene can also be toxic to people and other animals. Most pesticide products containing paradichlorobenzene in the U.S. are used to control clothes moths in airtight containers. Paradichlorobenzene was first registered for use in the United States in 1942, and it is sometimes called 1,4-dichlorobenzene.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cytochrome P450 2A5 3 Target ID: CHEMBL4085 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19110342 \| https://www.ncbi.nlm.nih.gov/pubmed/15658857	Inhibitor 8504		1.0 µM [IC50]
estrogen metabolic process 1 Target ID: GO:0008210 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17593412	Modulator 846

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Organic air pollutants inside and outside residences in Shimizu, Japan: levels, sources and risks.	2006-08-01	16298419
Analysis of chemical contamination within a canal in a Mexican border colonia.	2006-04	16168540
Genotoxicity and toxicity assessment in urban hydrographic basins.	2006-01-31	16413222
Higher triplet excited states of benzophenones and bimolecular triplet energy transfer measured by using nanosecond-picosecond two-color/two-laser flash photolysis.	2005-11-04	16078292
Carcinogenicity and chronic toxicity in mice and rats exposed by inhalation to para-dichlorobenzene for two years.	2005-10	16276058
Gas chromatography-mass spectroscopy analysis of emissions from cement when using ultrasonically driven tools.	2005-10	16263610
Rhodococcus phenolicus sp. nov., a novel bioprocessor isolated actinomycete with the ability to degrade chlorobenzene, dichlorobenzene and phenol as sole carbon sources.	2005-10	16261859
Determination of 1,2-dibromoethane, 1,4-dichlorobenzene and naphthalene residues in honey by gas chromatography--mass spectrometry using purge and trap thermal desorption extraction.	2005-08-12	16078701
Tissue-dependent distribution and accumulation of chlorobenzenes by vegetables in urban area.	2005-08	16002141
Communication and re-use of chemical information in bioscience.	2005-07-18	16026614
Cross-linking of polyolefins: a study by thermoporosimetry with benzene derivatives as swelling solvents.	2005-06-13	15900520
A thermodynamically based method to quantify true sorption hysteresis.	2005-05-13	15888892
A field comparison of volatile organic compound measurements using passive organic vapor monitors and stainless steel canisters.	2005-05-01	15926577
Thirteen-week inhalation toxicity of p-dichlorobenzene in mice and rats.	2005-05	15953847
Effects of perinatal combined exposure to 1,4-dichlorobenzene and 1,1-dichloro-2, 2-bis (p-chlorophenyl) ethylene on rat male offspring.	2005-05	15853928
Structure of toluene6.4-ZSM-5 and the toluene disproportionation reaction on ZSM-5.	2005-04	15772448
Children's exposure to volatile organic compounds as determined by longitudinal measurements in blood.	2005-03	15743726
Structure relationship for catalytic dechlorination rate of dichlorobenzenes in water.	2005-03	15694469
[Experimental study on repairing segmental bone defects with three bio-bone derived materials].	2005-02	15759926
Catalytic dechlorination kinetics of p-dichlorobenzene over Pd/Fe catalysts.	2005-02	15664621
Priority volatile organic compounds in surface waters of the southern North Sea.	2005-01	15519456
Levels of polychlorinated biphenyls in 1,4-dichlorobenzene mothballs.	2005	15900770
Advanced oxidation degradation of dichlorobenzene in water by the UV/H2O2 process.	2005	15792297
Photochemical organic oxidations and dechlorinations with a mu-oxo bridged heme/non-heme diiron complex.	2004-12-27	15606173
C1 to C9 volatile organic compound measurements in urban air.	2004-12-01	15504503
Formation of PCDD/Fs and PCBs in the process of production of 1,4-dichlorobenzene.	2004-12	15519376
Snoring in primary school children and domestic environment: a Perth school based study.	2004-11-04	15527500
[Dechlorination of p-dichlorobenzene by metallic catalytic reduction technology].	2004-11	15759890
Evaluation of solubilizing ability of humic aggregate basing on the phase-separation model.	2004-11	15350405
Symptoms in relation to chemicals and dampness in newly built dwellings.	2004-10	15558298
Outdoor, indoor, and personal exposure to VOCs in children.	2004-10	15471730
1,4-dichlorobenzene marine risk assessment with special reference to the OSPARCOM region: North Sea.	2004-10	15376382
Effects of four chlorobenzenes on serum sex steroids and hepatic microsome enzyme activities in crucian carp, Carassius auratus.	2004-10	15294436
Effects of perinatal combined exposure to 1,4-dichlorobenzene and 1,1-dichloro-2, 2-bis (p-chlorophenyl) ethylene (p,p'-DDE) on rat female offspring.	2004-09	15447738
Analysis of volatile and semivolatile hydrocarbons recovered from steam-classified municipal solid waste.	2004-07-16	15254138
On line biomonitors used as a tool for toxicity reduction evaluation of in situ groundwater remediation techniques.	2004-07-15	15142606
Electrochemistry of metal phthalocyanines in organic solvents at variable pressure.	2004-07-12	15236564
Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in 1,4-dichlorobenzene mothballs.	2004-07	15386077
Electrochemical reduction of organohalogen compound by noble metal sintered electrode.	2004-07	15120565
Fate of volatile organic compounds in constructed wastewater treatment wetlands.	2004-04-01	15112826
Emission of volatile organic compounds during composting of municipal solid wastes.	2004-04	15026225
Diffusion-based calibration for solid-phase microextraction of benzene, toluene, ethylbenzene, p-xylene and chlorobenzenes from aqueous samples.	2004-01-30	14753665
[Interdisciplinary diagnostics in the outpatient treatment department of an environmental medical centre - report on experience with 400 patients].	2004-01	14767789
Analysis of BTEX and other substituted benzenes in water using headspace SPME-GC-FID: method validation.	2004-01	14737474
[Hygienic standards of the occupational air quality established by the Experts on Chemical Agents, 2002].	2004	15156761
Ambient, indoor and personal exposure relationships of volatile organic compounds in Mexico City Metropolitan Area.	2004	15118753
Differences in source emission rates of volatile organic compounds in inner-city residences of New York City and Los Angeles.	2004	15118751
Spatial and temporal variability of priority volatile organic compounds in the Scheldt estuary.	2003-10-01	15276740
Bacterial community dynamics during biostimulation and bioaugmentation experiments aiming at chlorobenzene degradation in groundwater.	2003-08	14708742
1,4-Dichlorobenzene.	2002	15323033

Patents

Sample Use Guides

In Vivo Use Guide

Mice: In an MNT, male and female NMRI mice were treated orally with single dose of 2500mg/kg Paradichlorobenzen. Intraperitoneal treatments of male and female mice with 2 x 177.5 and 2 x 355mg/kg.

Route of Administration: Other

In Vitro Use Guide

Significant dose-dependent increases of DNA fragmentation, as measured by the Comet assay, and of micronuclei frequency were obtained in primary kidney cells from both rats and humans with the following concentrations of Paradichlorobenzene: from 1.8 to 5.6 mM.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:33:16 GMT 2025` Edited by `admin` on `Mon Mar 31 17:33:16 GMT 2025`
Record UNII	D149TYB5MK
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

1,4-DICHLOROBENZENE

Systematic Name

English

PARADICHLOROBENZENE

Preferred Name

English

DICHLORICIDE

Brand Name

English

NSC-36935

Code

English

BENZENE, 1,4-DICHLORO-

Common Name

English

PARADICHLOROBENZENE [MART.]

Common Name

English

Paradichlorobenzene [WHO-DD]

Common Name

English

1,4-DICHLOROBENZENE [HSDB]

Common Name

English

DICHLOROBENZENE, P-

Common Name

English

P-DICHLOROBENZENE

Common Name

English

P-DICHLOROBENZENE [MI]

Common Name

English

PARADICHLOROBENZENE [VANDF]

Common Name

English

PARACIDE

Common Name

English

PARAMOTH

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C45386