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Details

Stereochemistry ACHIRAL
Molecular Formula C6H4Cl2
Molecular Weight 147.002
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 1,4-DICHLOROBENZENE

SMILES

ClC1=CC=C(Cl)C=C1

InChI

InChIKey=OCJBOOLMMGQPQU-UHFFFAOYSA-N
InChI=1S/C6H4Cl2/c7-5-1-2-6(8)4-3-5/h1-4H

HIDE SMILES / InChI

Description

Paradichlorobenzene is a chlorinated aromatic hydrocarbon. It is a fumigant insecticide and repellent. Paradichlorobenzene turns directly from a solid into a gas, a process called sublimation. The target organisms are molds, mildews, and insects, but paradichlorobenzene can also be toxic to people and other animals. Most pesticide products containing paradichlorobenzene in the U.S. are used to control clothes moths in airtight containers. Paradichlorobenzene was first registered for use in the United States in 1942, and it is sometimes called 1,4-dichlorobenzene.

CNS Activity

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
1.0 µM [IC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct

PubMed

Sample Use Guides

In Vivo Use Guide
Mice: In an MNT, male and female NMRI mice were treated orally with single dose of 2500mg/kg Paradichlorobenzen. Intraperitoneal treatments of male and female mice with 2 x 177.5 and 2 x 355mg/kg.
Route of Administration: Other
In Vitro Use Guide
Significant dose-dependent increases of DNA fragmentation, as measured by the Comet assay, and of micronuclei frequency were obtained in primary kidney cells from both rats and humans with the following concentrations of Paradichlorobenzene: from 1.8 to 5.6 mM.