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Showing 1 - 10 of 21 results

Status:
US Approved Rx (2016)
First marketed in 1921

Class (Stereo):
CHEMICAL (ACHIRAL)



Methylene blue, also known as methylthioninium chloride, is a medication from WHO's list of essential medicines. Upon administration, methylene blue is converted to leukomethylene blue by erythrocyte methemoblobin reductase in the presence of NADPH. ...
Status:
Investigational

Class (Stereo):
CHEMICAL (ABSOLUTE)



Juvantia Pharma and Orion developed ORM-12741, also known as ORM-10921, a novel selective antagonist of alpha-2C adrenoceptors for the treatment of depression and Alzheimer's disease. ORM-12741 participated in phase II clinical trial where was evalua...
Status:
Investigational

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Anisodamine is a naturally occurring atropine derivative that has been isolated, synthesized and characterized by scientists in the People's Republic of China. Anisodamine is a non-specific cholinergic antagonist. Anisodamine has been shown to intera...
PD-198306 is a cell-permeable, amino-benzamide derivative that acts as a potent and non-ATP-competitive inhibitor of MEK1/2 with an excellent selectivity over ERK, c-Src, Cdk's, and phosphatidylinositol 3-kinase γ. In vitro PD-198306 inhibits MEK act...
Status:
Other

Class (Stereo):
CHEMICAL (RACEMIC)



RO-20-1724 is a potent inhibitor of Phosphodiesterase 4 (PDE4) originally developed by Roche. It showed some promise as a potential treatment for psoriasis, but it was discontinued when it could not match the efficacy of existing treatments. RO-20-...
Ro 5-3335, 7-chloro-5-(2-pyrryl)-3H-1,4-benzo-diazepin-2-(H)-one, is a benzodiazepine compound. Originally Ro 5-3335 was shown to inhibit gene expression controlled by the human immunodeficiency virus-1 (HIV-1) LTR promoter. The inhibition was specif...
Status:
Possibly Marketed Outside US
First approved in 1992

Class (Stereo):
CHEMICAL (ABSOLUTE)



Glabridin is an isoflavane found in the root extract of licorice (Glycyrrhiza glabra). Glabridin is considered to be a phytoestrogen and has been associated with numerous biological properties ranging from antioxidant, anti-inflammatory, neuroprotect...
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)



Dopexamine hydrochloride is a synthetic catecholamine, structurally related to dopamine, with marked intrinsic agonist activity at beta 2-adrenoceptors, lesser agonist activity at dopamine DA1- and DA2-receptors and beta 1-adrenoceptors, and an inhib...
Status:
US Approved Rx (2017)
First approved in 2017

Class:
PROTEIN



Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. It is part of the renin-angiotensin system, which is a major target for drugs that lower blood pressure. Angiotensin also stimulates the releas...
Status:
US Approved Rx (2016)
First marketed in 1921

Class (Stereo):
CHEMICAL (ACHIRAL)



Methylene blue, also known as methylthioninium chloride, is a medication from WHO's list of essential medicines. Upon administration, methylene blue is converted to leukomethylene blue by erythrocyte methemoblobin reductase in the presence of NADPH. ...