U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
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Showing 1 - 10 of 12 results

Status:
US Approved Rx (2023)
First approved in 2023

Class (Stereo):
CHEMICAL (ABSOLUTE)



Omaveloxolone (RTA-408) is a synthetic triterpenoid exerting antioxidant inflammation modulator properties. It activates the transcription factor Nrf2 and inhibits NF-κB signaling. Omaveloxolone demonstrated antioxidant, anti-inflammatory, and antica...
Status:
US Approved Rx (2013)
First approved in 1999

Class (Stereo):
CHEMICAL (RACEMIC)



Pioglitazone (brand name Actos) is a prescription drug of the thiazolidinedione class with hypoglycemic action used in the treatment of type 2 diabetes. Pioglitazone selectively stimulates the nuclear receptor peroxisome proliferator-activated recept...
Status:
US Approved OTC
First approved in 1955

Class (Stereo):
CHEMICAL (ACHIRAL)



Dyclonine is an local anesthetic used to provide topical anesthesia to mucous membranes through sodium channel inhibition. It is the active ingredient in Sucrets, an over-the-counter throat lozenge. It has been used as a local anesthetic agent prior ...
Status:
Investigational

Class (Stereo):
CHEMICAL (ACHIRAL)



3-Indolepropionic acid (IN-OX1; Indole-3-propionic acid; OX-1; Oxigon; SHP 22; SHP-622; VP-20629), an endogenous substance produced by bacteria in the intestine, is a deamination product of Tryptophan (T947200) that protects the hippocampus (studied ...
Status:
Designated

Class (Stereo):
CHEMICAL (ACHIRAL)



RG2833 is a compound originally developed by the Scripps Insitute for the treatment of Friedrick's Ataxia. RG2833 is a potent and selective inhibitor of neuronal histone deacetylase. RG2833 has been granted orphan drug status has been investigated ...
Status:
Possibly Marketed Outside US
First approved in 2011

Class (Stereo):
CHEMICAL (ABSOLUTE)



Cianidanol is an antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms. One of the polyphenols present in green tea, (+)-catechin (Cianidanol), has been studied for its effects on animal mode...
Status:
Possibly Marketed Outside US
First approved in 2011

Class (Stereo):
CHEMICAL (ACHIRAL)



Idebenone is a synthetic short-chain benzoquinone and a substrate for the enzyme NAD(P)H:quinone oxidoreductase (NQO1) capable of stimulating mitochondrial electron transport and supplementing cellular energy levels. Idebenone was initially developed...
Status:
Possibly Marketed Outside US
First approved in 2010

Class (Stereo):
CHEMICAL (ACHIRAL)



Ethyl linoleate (ELA) is an essential fatty acid used in many cosmetics for its anti-inflammatory properties. It inhibits the action of the reactive species of oxygen released by neutrophils due to an excess of bacteria, and prevents the hyperkeratin...
Status:
US Approved Rx (2013)
First approved in 1999

Class (Stereo):
CHEMICAL (RACEMIC)



Pioglitazone (brand name Actos) is a prescription drug of the thiazolidinedione class with hypoglycemic action used in the treatment of type 2 diabetes. Pioglitazone selectively stimulates the nuclear receptor peroxisome proliferator-activated recept...
Status:
US Approved Rx (2013)
First approved in 1999

Class (Stereo):
CHEMICAL (RACEMIC)



Pioglitazone (brand name Actos) is a prescription drug of the thiazolidinedione class with hypoglycemic action used in the treatment of type 2 diabetes. Pioglitazone selectively stimulates the nuclear receptor peroxisome proliferator-activated recept...

Showing 1 - 10 of 12 results