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Condition

Dicumarol toxicity

3

Unknown

2,596

Pain

619

Cancer

609

Hypertension

575

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Development Status

US Previously Marketed

3

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Primary Target

Aldose reductase (Gallus gallus)

3

Heme oxygenase 1

3

NQO1 protein

3

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Highest Phase

Phase III

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Approval Year

1940

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Treatment Modality

Primary

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Originator

Fieser, L.F.

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Chemical

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CAS

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CHEBI

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FDA UNII

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PUBCHEM

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Substance Form

Salts, Hydrates, Esters, etc.

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MENADIONE BISULFITE

I2BE1ZEN8I

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Status:

US Previously Marketed

First approved in 1940

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Heme oxygenase 1

Aldose reductase (Gallus gallus)

Conditions:

Dicumarol toxicity

Vomiting of pregnancy

Organophosphorus pesticides intoxication

Menadione bisulfite is a water-soluble analog of Vitamin K3. Pharmacologic studies on menadione bisulfate indicad that its toxicity is relatively low. In man, doses approximately ten times as great as those generally recommended for therapeutic use,...

given daily for a period of one week. Redox cycling compounds, such as menadione, have the potential to effectively mitigate the toxicity of organophosphorus pesticides including parathion. Menadione bisulfite behaved as a competitive inhibitor of chicken muscle aldose reductase.

MENADIONE SODIUM BISULFITE ANHYDROUS

97K34V88SA

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Status:

US Previously Marketed

First approved in 1940

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Heme oxygenase 1

Aldose reductase (Gallus gallus)

Conditions:

Dicumarol toxicity

Vomiting of pregnancy

Organophosphorus pesticides intoxication

Menadione bisulfite is a water-soluble analog of Vitamin K3. Pharmacologic studies on menadione bisulfate indicad that its toxicity is relatively low. In man, doses approximately ten times as great as those generally recommended for therapeutic use,...

given daily for a period of one week. Redox cycling compounds, such as menadione, have the potential to effectively mitigate the toxicity of organophosphorus pesticides including parathion. Menadione bisulfite behaved as a competitive inhibitor of chicken muscle aldose reductase.

MENADIONE SODIUM BISULFITE

6XF3C2HK77

Export Data
Search for Structure

Status:

US Previously Marketed

First approved in 1940

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Heme oxygenase 1

Aldose reductase (Gallus gallus)

Conditions:

Dicumarol toxicity

Vomiting of pregnancy

Organophosphorus pesticides intoxication

Menadione bisulfite is a water-soluble analog of Vitamin K3. Pharmacologic studies on menadione bisulfate indicad that its toxicity is relatively low. In man, doses approximately ten times as great as those generally recommended for therapeutic use,...

given daily for a period of one week. Redox cycling compounds, such as menadione, have the potential to effectively mitigate the toxicity of organophosphorus pesticides including parathion. Menadione bisulfite behaved as a competitive inhibitor of chicken muscle aldose reductase.

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