U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
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Showing 1 - 10 of 58 results

Status:
US Approved Rx (2020)
First approved in 1974

Class (Stereo):
CHEMICAL (RACEMIC)



Ibuprofen is a nonsteroidal anti-inflammatory agent (NSAIA) or nonsteroidal anti-inflammatory drug (NSAID), with analgesic and antipyretic properties. Ibuprofen has pharmacologic actions similar to those of other prototypical NSAIAs, which are though...
Status:
US Approved Rx (2011)
First approved in 1953

Class (Stereo):
CHEMICAL (ABSOLUTE)



Methscopolamine bromide is an anticholinergic agent used along with other medications to treat peptic ulcers by reducing stomach acid secretion. Methscopolamine is also commonly used as a drying agent, to dry up post-nasal drip, in cold, irritable bo...
Status:
US Approved Rx (2018)
First approved in 1950

Class (Stereo):
CHEMICAL (ACHIRAL)



Acetaminophen, also known as paracetamol, is commonly used for its analgesic and antipyretic effects. Its therapeutic effects are similar to salicylates, but it lacks anti-inflammatory, antiplatelet, and gastric ulcerative effects. Acetaminophen (USA...
Status:
US Approved OTC
First approved in 2014

Class (Stereo):
CHEMICAL (ABSOLUTE)



Levomethamphetamine is the levorotary (L-enantiomer) form of methamphetamine. Levomethamphetamine is a sympathomimetic vasoconstrictor which is the active ingredient in some over-the-counter (OTC) nasal decongestant inhalers in the United States. Le...
Status:
US Approved OTC
First approved in 1961

Class (Stereo):
CHEMICAL (RACEMIC)


Guaifenesin is an expectorant the action of which promotes or facilitates the removal of secretions from the respiratory tract. The precise mechanism of action of guaifenesin is not known; however, it is thought to act as an expectorant by increasing...
Status:
US Approved OTC
First approved in 1959

Class (Stereo):
CHEMICAL (ACHIRAL)



Xylometazoline, also spelled xylomethazoline, is a medication which is used to improve symptoms of nasal congestion, allergic rhinitis, and sinusitis. Xylometazoline was patented in 1956 and came into medical use in 1959. It is on the World Health O...
Status:
US Approved OTC
First approved in 1959

Class (Stereo):
CHEMICAL (ABSOLUTE)



DEXBROMPHENIRAMINE is an alkylamine derivative with anticholinergic and sedative properties. It is a histamine H1-receptor antagonist that competes with histamine for the H1-receptor sites on effector cells in the gastrointestinal tract, blood vessel...
Status:
US Approved OTC
First approved in 1958

Class (Stereo):
CHEMICAL (ACHIRAL)



Triprolidine is a first generation histamine H1 antagonist, which in combination with codeine phosphate and pseudoephedrine hydrochloride is sold under brand name TRIACIN-C. TRIACIN-C is indicated for temporary relief of coughs and upper respiratory...
Status:
US Approved OTC
First approved in 1956

Class (Stereo):
CHEMICAL (RACEMIC)



Brompheniramine is an antihistaminergic medication of the propylamine class. It is a first-generation antihistamine, which is used for the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes...
Status:
US Approved OTC
First marketed in 1921

Class (Stereo):
CHEMICAL (ABSOLUTE)



Menthyl lactate is derived from menthol, a compound that comes from peppermint oil, or is made synthetically. Menthol has a natural cooling effect, which makes it useful as a topical analgesic to treat skin irritation, pain, itching or sunburn. Despi...