Details
Stereochemistry | RACEMIC |
Molecular Formula | C10H14O4 |
Molecular Weight | 198.2158 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC=CC=C1OCC(O)CO
InChI
InChIKey=HSRJKNPTNIJEKV-UHFFFAOYSA-N
InChI=1S/C10H14O4/c1-13-9-4-2-3-5-10(9)14-7-8(12)6-11/h2-5,8,11-12H,6-7H2,1H3
Guaifenesin is an expectorant the action of which promotes or facilitates the removal of secretions from the respiratory tract. The precise mechanism of action of guaifenesin is not known; however, it is thought to act as an expectorant by increasing the volume and reducing the viscosity of secretions in the trachea and bronchi. In turn, this may increase the efficiency of the cough reflex and facilitate removal of the secretions. Guaifenesin is over-the-counter drug for the treatment of cough and common cold.
Approval Year
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Palliative | MUCINEX Approved UseUses helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive Launch Date2002 |
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Palliative | MUCINEX Approved UseUses helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive Launch Date2002 |
Cmax
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
3.7 μg/mL |
400 mg single, oral dose: 400 mg route of administration: Oral experiment type: SINGLE co-administered: |
GUAIFENESIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
AUC
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
4.2 μg × h/mL |
400 mg single, oral dose: 400 mg route of administration: Oral experiment type: SINGLE co-administered: |
GUAIFENESIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
1 h |
400 mg single, oral dose: 400 mg route of administration: Oral experiment type: SINGLE co-administered: |
GUAIFENESIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
Doses
Dose | Population | Adverse events |
---|---|---|
400 mg 6 times / day steady, oral Highest studied dose Dose: 400 mg, 6 times / day Route: oral Route: steady Dose: 400 mg, 6 times / day Sources: |
healthy, 31. 3 years (range: 19–50 years) n = 24 Health Status: healthy Age Group: 31. 3 years (range: 19–50 years) Sex: M+F Population Size: 24 Sources: |
Other AEs: Headache, Sore throat... Other AEs: Headache Sources: Sore throat Indigestion Nose bleed Eye infection |
1200 mg 2 times / day steady, oral Highest studied dose|Recommended Dose: 1200 mg, 2 times / day Route: oral Route: steady Dose: 1200 mg, 2 times / day Sources: |
healthy, 31. 3 years (range: 19–50 years) n = 24 Health Status: healthy Age Group: 31. 3 years (range: 19–50 years) Sex: M+F Population Size: 24 Sources: |
Other AEs: Headache, Sore throat... Other AEs: Headache Sources: Sore throat Indigestion Nose bleed Eye infection |
600 mg 2 times / day multiple, oral Dose: 600 mg, 2 times / day Route: oral Route: multiple Dose: 600 mg, 2 times / day Sources: |
unhealthy, 63.7 years n = 12 Health Status: unhealthy Condition: filamentary keratitis Age Group: 63.7 years Sex: M+F Population Size: 12 Sources: |
Disc. AE: Vomiting, Diarrhea... AEs leading to discontinuation/dose reduction: Vomiting (1 patient) Sources: Diarrhea (1 patient) |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Eye infection | 400 mg 6 times / day steady, oral Highest studied dose Dose: 400 mg, 6 times / day Route: oral Route: steady Dose: 400 mg, 6 times / day Sources: |
healthy, 31. 3 years (range: 19–50 years) n = 24 Health Status: healthy Age Group: 31. 3 years (range: 19–50 years) Sex: M+F Population Size: 24 Sources: |
|
Headache | 400 mg 6 times / day steady, oral Highest studied dose Dose: 400 mg, 6 times / day Route: oral Route: steady Dose: 400 mg, 6 times / day Sources: |
healthy, 31. 3 years (range: 19–50 years) n = 24 Health Status: healthy Age Group: 31. 3 years (range: 19–50 years) Sex: M+F Population Size: 24 Sources: |
|
Indigestion | 400 mg 6 times / day steady, oral Highest studied dose Dose: 400 mg, 6 times / day Route: oral Route: steady Dose: 400 mg, 6 times / day Sources: |
healthy, 31. 3 years (range: 19–50 years) n = 24 Health Status: healthy Age Group: 31. 3 years (range: 19–50 years) Sex: M+F Population Size: 24 Sources: |
|
Nose bleed | 400 mg 6 times / day steady, oral Highest studied dose Dose: 400 mg, 6 times / day Route: oral Route: steady Dose: 400 mg, 6 times / day Sources: |
healthy, 31. 3 years (range: 19–50 years) n = 24 Health Status: healthy Age Group: 31. 3 years (range: 19–50 years) Sex: M+F Population Size: 24 Sources: |
|
Sore throat | 400 mg 6 times / day steady, oral Highest studied dose Dose: 400 mg, 6 times / day Route: oral Route: steady Dose: 400 mg, 6 times / day Sources: |
healthy, 31. 3 years (range: 19–50 years) n = 24 Health Status: healthy Age Group: 31. 3 years (range: 19–50 years) Sex: M+F Population Size: 24 Sources: |
|
Eye infection | 1200 mg 2 times / day steady, oral Highest studied dose|Recommended Dose: 1200 mg, 2 times / day Route: oral Route: steady Dose: 1200 mg, 2 times / day Sources: |
healthy, 31. 3 years (range: 19–50 years) n = 24 Health Status: healthy Age Group: 31. 3 years (range: 19–50 years) Sex: M+F Population Size: 24 Sources: |
|
Headache | 1200 mg 2 times / day steady, oral Highest studied dose|Recommended Dose: 1200 mg, 2 times / day Route: oral Route: steady Dose: 1200 mg, 2 times / day Sources: |
healthy, 31. 3 years (range: 19–50 years) n = 24 Health Status: healthy Age Group: 31. 3 years (range: 19–50 years) Sex: M+F Population Size: 24 Sources: |
|
Indigestion | 1200 mg 2 times / day steady, oral Highest studied dose|Recommended Dose: 1200 mg, 2 times / day Route: oral Route: steady Dose: 1200 mg, 2 times / day Sources: |
healthy, 31. 3 years (range: 19–50 years) n = 24 Health Status: healthy Age Group: 31. 3 years (range: 19–50 years) Sex: M+F Population Size: 24 Sources: |
|
Nose bleed | 1200 mg 2 times / day steady, oral Highest studied dose|Recommended Dose: 1200 mg, 2 times / day Route: oral Route: steady Dose: 1200 mg, 2 times / day Sources: |
healthy, 31. 3 years (range: 19–50 years) n = 24 Health Status: healthy Age Group: 31. 3 years (range: 19–50 years) Sex: M+F Population Size: 24 Sources: |
|
Sore throat | 1200 mg 2 times / day steady, oral Highest studied dose|Recommended Dose: 1200 mg, 2 times / day Route: oral Route: steady Dose: 1200 mg, 2 times / day Sources: |
healthy, 31. 3 years (range: 19–50 years) n = 24 Health Status: healthy Age Group: 31. 3 years (range: 19–50 years) Sex: M+F Population Size: 24 Sources: |
|
Diarrhea | 1 patient Disc. AE |
600 mg 2 times / day multiple, oral Dose: 600 mg, 2 times / day Route: oral Route: multiple Dose: 600 mg, 2 times / day Sources: |
unhealthy, 63.7 years n = 12 Health Status: unhealthy Condition: filamentary keratitis Age Group: 63.7 years Sex: M+F Population Size: 12 Sources: |
Vomiting | 1 patient Disc. AE |
600 mg 2 times / day multiple, oral Dose: 600 mg, 2 times / day Route: oral Route: multiple Dose: 600 mg, 2 times / day Sources: |
unhealthy, 63.7 years n = 12 Health Status: unhealthy Condition: filamentary keratitis Age Group: 63.7 years Sex: M+F Population Size: 12 Sources: |
PubMed
Title | Date | PubMed |
---|---|---|
Potentiating effects of chlorpromazine on the paralysis and toxicity induced by guaiacal glyceryl ether in rats. | 1972 Dec |
|
Hypertension in bulls and steers anesthetized with guaifenesin-thiobarbiturate-halothane combination. | 1986 Jul |
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Fulminant hepatic failure associated with clarithromycin. | 1996 Feb |
|
Abuse of guaifenesin-containing medications generates an excess of a carboxylate salt of beta-(2-methoxyphenoxy)-lactic acid, a guaifenesin metabolite, and results in urolithiasis. | 1999 Jul |
|
Bilateral guaifenesin ureteral calculi. | 2004 Jan |
|
Spontaneous dissolution of a guaifenesin stone. | 2005 Aug |
|
Dextromethorphan-induced delirium and possible methadone interaction. | 2005 Mar |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2007/021282s021,021585s012,021620s011lbl.pdf
Curator's Comment: Guaifenesin can also be given in syrup form.
1 tablet every 12 hours (adults and children 12 years of age and over).
Route of Administration:
Oral
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/10424525
Sputum or mucus simulants were analyzed untreated and after the addition of guaifenesin at 1:5 volume to volume ratio for a contact period of 60 s. The concentration of guaifenesin was 20 mg/mL.
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Classification Tree | Code System | Code | ||
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WHO-VATC |
QR05CA03
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NCI_THESAURUS |
C29767
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CFR |
21 CFR 522.1086
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WHO-VATC |
QM03BX90
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CFR |
21 CFR 341.78
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CFR |
21 CFR 341.18
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CFR |
21 CFR 522.1085
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WHO-ATC |
R05CA03
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Guaifenesin
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C29081
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GUAIFENESIN
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ACTIVE MOIETY
METABOLITE (PARENT)
PARENT (METABOLITE)
SALT/SOLVATE (PARENT)