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Condition

Chronic pancreatitis

3

Unknown

2,596

Pain

619

Cancer

609

Hypertension

575

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Development Status

Possibly Marketed Outside US

2

US Previously Marketed

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Primary Target

Amiloride-sensitive sodium channel, ENaC

2

Matriptase

2

Plasma kallikrein

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Prostasin

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Trypsin

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Approved

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Approval Year

Unknown

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1964

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CNS Activity

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Wackenroder, H.W.F.

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CHEBI

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ChEMBL

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DRUG BANK

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EPA CompTox

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ATC Level 1

ALIMENTARY TRACT AND METABOLISM

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EMOLLIENTS AND PROTECTIVES

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ATC Level 3

ANTIFIBRINOLYTICS

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VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO

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ATC Level 4

Protectives against UV-radiation for systemic use

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Proteinase inhibitors

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Vitamin A, plain

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BETA CAROTENE

01YAE03M7J

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Status:

US Previously Marketed

First approved in 1964

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Hypoxia-inducible factor 1-alpha

singlet excited oxygen

Protein delta homolog 1

POU domain, class 5, transcription factor 1

Conditions:

Macular degeneration

Head and neck cancer

Retinitis pigmentosa

Chronic pancreatitis

Cardiovascular diseases

Maternal mortality, fetal loss, or infant mortality

Erythropoietic protoporphyria

Beta-carotene is found in many foods and is sold as a dietary supplement. Beta-carotene is a carotenoid, weak antioxidant; precursor of vitamin A, which is essential for vision and growth. Used to reduce the severity of photosensitivity reactions in ...

patients with erythropoietic protoporphyria (EPP). Has been used in high-dose antioxidant supplements containing ascorbic acid and vitamin E with zinc in high-risk patients with age-related macular degeneration. Beta-carotene is also used to decrease asthma symptoms caused by exercise; to prevent certain cancers, heart disease, cataracts; and to treat AIDS, alcoholism, Alzheimer’s disease, depression, epilepsy, headache, heartburn, high blood pressure, infertility, Parkinson’s disease, rheumatoid arthritis, schizophrenia, and skin disorders including psoriasis and vitiligo.

CAMOSTAT

0FD207WKDU

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Status:

Possibly Marketed Outside US

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Amiloride-sensitive sodium channel, ENaC

Plasma kallikrein

Conditions:

Multiple sclerosis

Chronic pancreatitis

Postoperative reflux esophagitis

Hepatic fibrosis

Camostat mesilate (FOY-305) is a synthetic f low-molecular weight protease inhibitor. It is able to inhibit trypsin, prostasin, matriptase and plasma kallikrein. In addition camostat attenuates airway epithelial sodium channel function and enhances m...

ucociliary clearance. Camostat mesilate tablets (FOIPAN®) are approved in Japan and used for the treatment of remission of acute symptoms of chronic pancreatitis and postoperative reflux esophagitis.

CAMOSTAT MESYLATE

451M50A1EQ

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Status:

Possibly Marketed Outside US

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Amiloride-sensitive sodium channel, ENaC

Plasma kallikrein

Conditions:

Multiple sclerosis

Chronic pancreatitis

Postoperative reflux esophagitis

Hepatic fibrosis

Camostat mesilate (FOY-305) is a synthetic f low-molecular weight protease inhibitor. It is able to inhibit trypsin, prostasin, matriptase and plasma kallikrein. In addition camostat attenuates airway epithelial sodium channel function and enhances m...

ucociliary clearance. Camostat mesilate tablets (FOIPAN®) are approved in Japan and used for the treatment of remission of acute symptoms of chronic pancreatitis and postoperative reflux esophagitis.

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