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Details

Stereochemistry ACHIRAL
Molecular Formula C20H22N4O5.CH4O3S
Molecular Weight 494.518
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CAMOSTAT MESYLATE

SMILES

CS(O)(=O)=O.CN(C)C(=O)COC(=O)CC1=CC=C(OC(=O)C2=CC=C(NC(N)=N)C=C2)C=C1

InChI

InChIKey=FSEKIHNIDBATFG-UHFFFAOYSA-N
InChI=1S/C20H22N4O5.CH4O3S/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22;1-5(2,3)4/h3-10H,11-12H2,1-2H3,(H4,21,22,23);1H3,(H,2,3,4)

HIDE SMILES / InChI

Description

Camostat mesilate (FOY-305) is a synthetic f low-molecular weight protease inhibitor. It is able to inhibit trypsin, prostasin, matriptase and plasma kallikrein. In addition camostat attenuates airway epithelial sodium channel function and enhances mucociliary clearance. Camostat mesilate tablets (FOIPAN®) are approved in Japan and used for the treatment of remission of acute symptoms of chronic pancreatitis and postoperative reflux esophagitis.

CNS Activity

Approval Year

PubMed

PubMed

TitleDatePubMed
New orally active serine protease inhibitors.
1995 Jul 7
Acceleration of ulcer healing by cholecystokinin (CCK): role of CCK-A receptors, somatostatin, nitric oxide and sensory nerves.
1999 Jun 30
Different effects of oral administration of synthetic trypsin inhibitor on the pancreas between cholecystokinin-A receptor gene knockout mice and wild type mice.
2002 Jul
Differential mechanism and site of action of CCK on the pancreatic secretion and growth in rats.
2003 Oct
Preventive and therapeutic effects of the protease inhibitor camostat on pancreatic fibrosis and atrophy in CCK-1 receptor-deficient rats.
2005 Jan
Synthetic protease inhibitor camostat prevents and reverses dyslipidemia, insulin secretory defects, and histological abnormalities of the pancreas in genetically obese and diabetic rats.
2005 May
[Effects of Chinese herbal medicines on spontaneous chronic pancreatitis in rats and the pathological relationships between formulas and syndromes].
2006 Jul
ONO 3403, a synthetic serine protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-{alpha} and nitric oxide production and protects mice from lethal endotoxic shock.
2011 Feb
Reduced sodium transport with nasal administration of the prostasin inhibitor camostat in subjects with cystic fibrosis.
2013 Jul
Patents

Sample Use Guides

In Vivo Use Guide
1. Remission of acute symptoms of chronic pancreatitis. The usual dosage for oral use is 600 mg of camostat mesilate daily in three divided doses. The dosage may be adjusted according to the patient’s symptoms. 2. Postoperative reflux esophagitis. The usual dosage for oral use is 300 mg of camostat mesilate daily in three divided doses after each meal.
Route of Administration: Oral
In Vitro Use Guide
Camostat mesilate (500 uM) inhibited generation of TGF-beta by suppressing plasmin activity and reduced the activity of TGF-beta, which blocked in vitro activation of the rat hepatic stellate cells.
Name Type Language
CAMOSTAT MESYLATE
Common Name English
CAMOSTAT METHANESULFONATE [MI]
Common Name English
CAMOSTAT MESILATE [WHO-DD]
Common Name English
CAMOSTAT MESILATE [MART.]
Common Name English
CAMOSTAT MESILATE
MART.   WHO-DD  
Common Name English
CAMOSTAT MESILATE [JAN]
Common Name English
CAMOSTAT METHANESULFONATE
MI  
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C783
Created by admin on Tue Oct 22 05:42:39 UTC 2019 , Edited by admin on Tue Oct 22 05:42:39 UTC 2019
Code System Code Type Description
EVMPD
SUB01007MIG
Created by admin on Tue Oct 22 05:42:39 UTC 2019 , Edited by admin on Tue Oct 22 05:42:39 UTC 2019
PRIMARY
NCI_THESAURUS
C96364
Created by admin on Tue Oct 22 05:42:39 UTC 2019 , Edited by admin on Tue Oct 22 05:42:39 UTC 2019
PRIMARY
MERCK INDEX
M3000
Created by admin on Tue Oct 22 05:42:39 UTC 2019 , Edited by admin on Tue Oct 22 05:42:39 UTC 2019
PRIMARY Merck Index
EPA CompTox
59721-29-8
Created by admin on Tue Oct 22 05:42:39 UTC 2019 , Edited by admin on Tue Oct 22 05:42:39 UTC 2019
PRIMARY
ChEMBL
CHEMBL590799
Created by admin on Tue Oct 22 05:42:39 UTC 2019 , Edited by admin on Tue Oct 22 05:42:39 UTC 2019
PRIMARY
CAS
59721-29-8
Created by admin on Tue Oct 22 05:42:39 UTC 2019 , Edited by admin on Tue Oct 22 05:42:39 UTC 2019
PRIMARY
MESH
C034532
Created by admin on Tue Oct 22 05:42:39 UTC 2019 , Edited by admin on Tue Oct 22 05:42:39 UTC 2019
PRIMARY