Inxight Drugs

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Condition

Acute manic or mixed episodes associated with Bipolar I disorder

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Unknown

2,596

Pain

619

Cancer

609

Hypertension

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US Approved Rx

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Primary Target

Adrenergic receptor alpha-1

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Dopamine D2 receptor

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Serotonin 1d (5-HT1d) receptor

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Serotonin 2a (5-HT2a) receptor

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Approval Year

1993

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Primary

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Janssen Pharmaceutica

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Other antipsychotics

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RISPERIDONE

L6UH7ZF8HC

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Status:

US Approved Rx (2009)

First approved in 1993

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Dopamine D2 receptor

Serotonin 2a (5-HT2a) receptor

Adrenergic receptor alpha-1

Serotonin 1d (5-HT1d) receptor

Conditions:

Irritability associated with autistic disorder

Acute manic or mixed episodes associated with Bipolar I disorder

Risperidone, a benzisoxazole derivative, is an atypical antipsychotic drug with high affinity for 5-hydrotryptamine (5-HT) and dopamine D2 receptors. It is FDA approved for the treatment of schizophrenia, bipolar mania, irritability associated with a...

utistic disorder. Carbamazepine and other enzyme inducers decrease plasma concentrations of risperidone. Vice versa, Fluoxetine, paroxetine, and other CYP 2D6 enzyme inhibitors increase plasma concentrations of risperidone. Common adverse reactions include increased mortality in elderly patients with dementia-related psychosis, cerebrovascular adverse events, including stroke, in elderly patients with dementia-related psychosis, neuroleptic malignant syndrome, tardive dyskinesia , metabolic Changes (hyperglycemia and diabetes mellitus, dyslipidemia, weight gain), hyperprolactinemia, orthostatic hypotension, leukopenia, neutropenia, agranulocytosis, potential for cognitive and motor impairment, seizures, dysphagia, priapism, disruption of body temperature regulation.

RISPERIDONE HEXANOATE

FQ117R8W8H

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Search for Structure

Status:

US Approved Rx (2009)

First approved in 1993

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Dopamine D2 receptor

Serotonin 2a (5-HT2a) receptor

Adrenergic receptor alpha-1

Serotonin 1d (5-HT1d) receptor

Conditions:

Irritability associated with autistic disorder

Acute manic or mixed episodes associated with Bipolar I disorder

Risperidone, a benzisoxazole derivative, is an atypical antipsychotic drug with high affinity for 5-hydrotryptamine (5-HT) and dopamine D2 receptors. It is FDA approved for the treatment of schizophrenia, bipolar mania, irritability associated with a...

utistic disorder. Carbamazepine and other enzyme inducers decrease plasma concentrations of risperidone. Vice versa, Fluoxetine, paroxetine, and other CYP 2D6 enzyme inhibitors increase plasma concentrations of risperidone. Common adverse reactions include increased mortality in elderly patients with dementia-related psychosis, cerebrovascular adverse events, including stroke, in elderly patients with dementia-related psychosis, neuroleptic malignant syndrome, tardive dyskinesia , metabolic Changes (hyperglycemia and diabetes mellitus, dyslipidemia, weight gain), hyperprolactinemia, orthostatic hypotension, leukopenia, neutropenia, agranulocytosis, potential for cognitive and motor impairment, seizures, dysphagia, priapism, disruption of body temperature regulation.

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