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Details

Stereochemistry ACHIRAL
Molecular Formula C23H27FN4O2
Molecular Weight 410.4845
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of RISPERIDONE

SMILES

CC1=C(CCN2CCC(CC2)C3=NOC4=C3C=CC(F)=C4)C(=O)N5CCCCC5=N1

InChI

InChIKey=RAPZEAPATHNIPO-UHFFFAOYSA-N
InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3

HIDE SMILES / InChI

Description

Risperidone, a benzisoxazole derivative, is an atypical antipsychotic drug with high affinity for 5-hydrotryptamine (5-HT) and dopamine D2 receptors. It is FDA approved for the treatment of schizophrenia, bipolar mania, irritability associated with autistic disorder. Carbamazepine and other enzyme inducers decrease plasma concentrations of risperidone. Vice versa, Fluoxetine, paroxetine, and other CYP 2D6 enzyme inhibitors increase plasma concentrations of risperidone. Common adverse reactions include increased mortality in elderly patients with dementia-related psychosis, cerebrovascular adverse events, including stroke, in elderly patients with dementia-related psychosis, neuroleptic malignant syndrome, tardive dyskinesia , metabolic Changes (hyperglycemia and diabetes mellitus, dyslipidemia, weight gain), hyperprolactinemia, orthostatic hypotension, leukopenia, neutropenia, agranulocytosis, potential for cognitive and motor impairment, seizures, dysphagia, priapism, disruption of body temperature regulation.

CNS Activity

Approval Year

PubMed

PubMed

TitleDatePubMed
Effective treatment of aggression and impulsivity in antisocial personality disorder with risperidone.
2001 Apr
Risperidone-induced retrograde ejaculation.
2001 Apr
An MRI study of basal ganglia volumes in first-episode schizophrenia patients treated with risperidone.
2001 Apr
Novel treatments for bipolar disorder.
2001 Apr
Dynamic dopamine-antagonist interactions at recombinant human dopamine D(2short) receptor: dopamine-bound versus antagonist-bound receptor states.
2001 Apr
Health care utilization in patients with schizophrenia maintained on atypical versus conventional antipsychotics.
2001 Feb
Dose relationship of limbic-cortical D2-dopamine receptor occupancy with risperidone.
2001 Feb
Treatment of psychogenic polydipsia: comparison of risperidone and olanzapine, and the effects of an adjunctive angiotensin-II receptor blocking drug (irbesartan).
2001 Feb
Addition of risperidone to clozapine therapy in chronically psychotic inpatients.
2001 Feb
Hyperthermia and chronic pancerebellar syndrome after cocaine abuse.
2001 Feb 26
Receptor-mediated regulation of serotonin output in the rat dorsal raphe nucleus: effects of risperidone.
2001 Jan
[Viewpoint of schizophrenic patients: a European survey].
2001 Jan-Feb
Effects of dopamine antagonists with different receptor blockade profiles on morphine-induced place preference in male mice.
2001 Jun
Effectiveness of ECT combined with risperidone against aggression in schizophrenia.
2001 Mar
Suspected induction of a pyoderma gangrenosum-like eruption due to sulpiride treatment.
2001 Mar
The evaluation of multiple surrogate endpoints.
2001 Mar
Estrogen - a potential treatment for schizophrenia.
2001 Mar 1
Effects of olanzapine and other antipsychotics on cognitive function in chronic schizophrenia: a longitudinal study.
2001 Mar 1
Short-term inpatient pharmacotherapy of schizophrenia.
2001 May-Jun
Patents

Sample Use Guides

In Vivo Use Guide
Initial dosing is generally 2 mg/day. Dose increases should then occur at intervals not less than 24 hours, in increments of 1–2 mg/day, as tolerated, to a recommended dose of 4–8 mg/day. Effective dose range - 0.5-16 mg (disease dependent).
Route of Administration: Intramuscular; Oral
In Vitro Use Guide
Measurement of ATP contents in the neuronal cell line showed significantly increased levels after a 24-h treatment with 25 microg/mL risperidone.
Name Type Language
RISPERIDONE
EP   HSDB   INN   JAN   MART.   MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD  
INN   USAN  
Official Name English
R-64766
Code English
R 64 766
Code English
RISPERIDONE [WHO-DD]
Common Name English
RISPERIDONE [USAN]
Common Name English
N05AX08
Code English
RISPERIDONE [ORANGE BOOK]
Common Name English
R-64,766
Code English
RISPERIDONE [HSDB]
Common Name English
RISPERIDONE [USP-RS]
Common Name English
RISPERIDONE [MART.]
Common Name English
RCN3028
Code English
RISPERDAL
Brand Name English
RCN-3028
Code English
RISPERIDONE [JAN]
Common Name English
3-(2-(4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)-1-PIPERIDINYL)ETHYL)-6,7,8,9-TETRAHYDRO-2-METHYL-4H-PYRIDO(1,2-A)PYRIMIDIN-4-ONE
Systematic Name English
R-64-766
Code English
RISPERIDONE [EP]
Common Name English
RISPERIDONE [INN]
Common Name English
RISPERIDONE [USP]
Common Name English
4H-PYRIDO(1,2-A)PYRIMIDIN-4-ONE, 3-(2-(4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)-1-PIPERIDINYL)ETHYL)-6,7,8,9-TETRAHYDRO-2-METHYL-
Systematic Name English
RISPERIDONE [VANDF]
Common Name English
RISPERIDONE [MI]
Common Name English
Classification Tree Code System Code
WHO-ATC N05AX08
Created by admin on Tue Mar 06 11:21:08 UTC 2018 , Edited by admin on Tue Mar 06 11:21:08 UTC 2018
NDF-RT N0000175430
Created by admin on Tue Mar 06 11:21:08 UTC 2018 , Edited by admin on Tue Mar 06 11:21:08 UTC 2018
WHO-VATC QN05AX08
Created by admin on Tue Mar 06 11:21:08 UTC 2018 , Edited by admin on Tue Mar 06 11:21:08 UTC 2018
LIVERTOX 852
Created by admin on Tue Mar 06 11:21:08 UTC 2018 , Edited by admin on Tue Mar 06 11:21:08 UTC 2018
Code System Code Type Description
ChEMBL
CHEMBL85
Created by admin on Tue Mar 06 11:21:08 UTC 2018 , Edited by admin on Tue Mar 06 11:21:08 UTC 2018
PRIMARY
EPA CompTox
106266-06-2
Created by admin on Tue Mar 06 11:21:08 UTC 2018 , Edited by admin on Tue Mar 06 11:21:08 UTC 2018
PRIMARY
HSDB
106266-06-2
Created by admin on Tue Mar 06 11:21:08 UTC 2018 , Edited by admin on Tue Mar 06 11:21:08 UTC 2018
PRIMARY
MERCK INDEX
M9631
Created by admin on Tue Mar 06 11:21:08 UTC 2018 , Edited by admin on Tue Mar 06 11:21:08 UTC 2018
PRIMARY Merck Index
PUBCHEM
5073
Created by admin on Tue Mar 06 11:21:08 UTC 2018 , Edited by admin on Tue Mar 06 11:21:08 UTC 2018
PRIMARY SWITZERF
WIKIPEDIA
RISPERIDONE
Created by admin on Tue Mar 06 11:21:08 UTC 2018 , Edited by admin on Tue Mar 06 11:21:08 UTC 2018
PRIMARY
MESH
D018967
Created by admin on Tue Mar 06 11:21:08 UTC 2018 , Edited by admin on Tue Mar 06 11:21:08 UTC 2018
PRIMARY
INN
6085
Created by admin on Tue Mar 06 11:21:08 UTC 2018 , Edited by admin on Tue Mar 06 11:21:08 UTC 2018
PRIMARY
LactMed
106266-06-2
Created by admin on Tue Mar 06 11:21:08 UTC 2018 , Edited by admin on Tue Mar 06 11:21:08 UTC 2018
PRIMARY
EVMPD
SUB10335MIG
Created by admin on Tue Mar 06 11:21:08 UTC 2018 , Edited by admin on Tue Mar 06 11:21:08 UTC 2018
PRIMARY
CAS
106266-06-2
Created by admin on Tue Mar 06 11:21:08 UTC 2018 , Edited by admin on Tue Mar 06 11:21:08 UTC 2018
PRIMARY
RXCUI
35636
Created by admin on Tue Mar 06 11:21:08 UTC 2018 , Edited by admin on Tue Mar 06 11:21:08 UTC 2018
PRIMARY RxNorm
NCI_THESAURUS
C29416
Created by admin on Tue Mar 06 11:21:08 UTC 2018 , Edited by admin on Tue Mar 06 11:21:08 UTC 2018
PRIMARY
IUPHAR
96
Created by admin on Tue Mar 06 11:21:08 UTC 2018 , Edited by admin on Tue Mar 06 11:21:08 UTC 2018
PRIMARY
DRUG BANK
DB00734
Created by admin on Tue Mar 06 11:21:08 UTC 2018 , Edited by admin on Tue Mar 06 11:21:08 UTC 2018
PRIMARY