U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 361 - 370 of 149123 results

Status:
Investigational
Source:
INN:exarafenib [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
INN:lorundrostat [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
INN:bleximenib [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
INN:managlinat dialanetil [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Managlinat dialanetil (MB06322 or CS-917) is an inhibitor of fructose 1,6-bisphphosphatase. Managlinat dialanetil is a bisamidate prodrug and its activation requires a two-step enzyme catalyzed reaction. Metabasis Therapeutics Inc in collaboration with Daiichi Sankyo Co Ltd was developing managlinat dialanetil for the potential treatment of type 2 diabetes.
Status:
Investigational
Source:
NCT01505907: Phase 1/Phase 2 Interventional Unknown status Healthy
(2012)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
INN:vamagloxistat [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
INN:luxdegalutamide [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
INN:nendratareotide [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
USAN:INDIUM CHLORIDES IN 113M [USAN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Indium Chloride In-113 is a salt of the only stable Indium isotope with applications in organic synthesis as a Lewis acid. Indium Chloride is the most available soluble derivative of indium with high reproductive toxicity. In in vitro models, Indium Chloride inhibits cell viability by elevating intracellular ROS and inducing apoptosis. In animal models Indium chloride exposure cause the accumulation of indium in blood and lung, bone marrow micronucleus rate increased, the occurrence of oxidative damage and pathological changes. Besides that, the indium chloride exposed showed significant toxicity to sperm function, as well as an increased percentage of sperm morphological abnormality and chromatin DNA damage.
Status:
Investigational
Source:
INN:feniralstat [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)