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Status:
Possibly Marketed Outside US
Source:
NDA207202
(2002)
Source URL:
First approved in 2002
Source:
NDA207202
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Cuprous Sulfide (Cu2S) occurs in nature as the mineral and has very different two-dimensional lattice structures, along with excellent electro-catalysis and high conductivity. Recently published article has shown that nanocomposites incorporated with Cu2S nanoflowers can be used for skin tumor therapy and wound healing.
Status:
Possibly Marketed Outside US
Source:
M017
(2020)
Source URL:
First approved in 2002
Source:
M003
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
First approved in 2002
Source:
NDA207202
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Gold chloride (AUCl3), dihydrate, also called gold trichloride or auric chlorise, is a compound comprised of gold and chloride. It exists as a chloride-bridged dimer, both as a solid and as a vapor. AUCl3 is very hygroscopic and highly soluble in water and ethanol. It is used in organic chemistry as a mild acid catalyst and as a alternative to mercury salts. It is known to cause allergic reactions in subjects with known gold allergy.
Status:
Possibly Marketed Outside US
First approved in 2002
Source:
NADA141207
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Danofloxacin is a quinolone antibacterial agent for veterinary medicine. The drug is approved by FDA for the treatment of bovine infectious respiratory disease under the name Advocin (mesylate salt). Danofloxacin exerts its action by inhibiting bacterial DNA gyrase.
Status:
Possibly Marketed Outside US
Source:
Acesulfame K by Hoechst
Source URL:
First approved in 2002
Source:
NDA022410
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Acesulfame is a non-nutritive sweetener Acesulfame potassium is a calorie-free artificial sweetener, also known as Acesulfame K or Ace K (K being the symbol for potassium), and marketed under the trade names Sunett and Sweet One. In the European Union, it is known under the E number (additive code) E950. It was discovered accidentally in 1967 by German chemist Karl Clauss at Hoechst AG (now Nutrinova). In chemical structure, acesulfame potassium is the potassium salt of 6-methyl-1,2,3- oxathiazine-4(3H)-one 2,2-dioxide. Acesulfame K has been approved for a variety of uses in more than 90 countries. In 1998, the FDA broadened the US approval of acesulfame K to allow its use in nonalcoholic beverages. It is often blended with sucralose and used to decrease the bitter aftertaste of aspartame. A wide range of low-calorie foods and drinks contain acesulfame K, including table-top sweeteners, chewing gum, jam, dairy products, frozen desserts, drinks and baked goods. Acesulfame K is not broken down when digested, nor is it stored in the body. After being consumed, it is quickly absorbed by the body and then rapidly excreted, unchanged.
Status:
Possibly Marketed Outside US
Source:
21 CFR 358
(2002)
Source URL:
First approved in 2002
Source:
21 CFR 358
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
Source:
21 CFR 358A
(2011)
Source URL:
First approved in 2002
Source:
21 CFR 358
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Kojic acid was first discovered in Japan in 1907. Kojic acid is a chelation agent produced by several species of fungi, especially Aspergillus oryzae, which has the Japanese common name koji. Kojic acid is a by-product in the fermentation process of malting rice, for use in the manufacturing of sake, the Japanese rice wine. It is a mild inhibitor of the formation of pigment in plant and animal tissues, and is used in food and cosmetics to preserve or change colors of substances. It forms a bright red complex with ferric ions. Kojic acid may be used on cut fruits to prevent oxidative browning, in seafood to preserve pink and red colors, and in cosmetics. In skin care products, kojic acid functions primarily as a skin-lightening agent. It is a potent tyrosinase inhibitor. It penetrates the upper skin layers and inhibits the production of epidermal melanin. As an example of the latter, it is used to treat skin diseases like melasma. Kojic acid also has antibacterial and antifungal properties. The cocrystals of kojic acid with quercetin were found to have two times better cytotoxic activity to human cervical cancer cells (HeLa) and human colon cancer cells (Caco-2) in comparison with quercetin itself.
Status:
Possibly Marketed Outside US
Source:
BRONZ REPAIR SEA AND TROPICS FACE SPF 25
Source URL:
First approved in 2002
Source:
21 CFR 348
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Status:
Possibly Marketed Outside US
Source:
Axona by Accera
Source URL:
First approved in 2002
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Tricaprylin is a triester of glycerin and caprylic acid. It is used as a fragrance ingredient, solvent, and primarily as an emollient in a variety of personal care products, including makeup, creams and lotions, deodorants, sunscreens, hair conditioners, and skin cleansers. Tricaprylin is an ingredient of Axona, a prescription medical food intended for the clinical dietary management of the metabolic processes associated with mild to moderate Alzheimer’s disease. Axona provides a simple and safe method to induce hyperketonemia, thus providing an alternative energy substrate to glucose in the brain of patients with AD. After oral administration of Axona, Tricaprylin in Axona is processed by enzymes in the gut, and the resulting medium-chain fatty acids (MCFAs) are absorbed into the blood supply leading to the liver. The MCFAs rapidly pass directly to the liver, where they undergo oxidation to form ketones. Since the liver does not use ketones, they are released into the circulation to be used by nonliver tissues. Some ketones can cross the blood-brain barrier and are then taken up by brain cells. While glucose is the brain’s chief energy source, ketones normally serve as the "backup" energy source. Ketones the body produces after Axona is consumed, act as an alternative energy source for brain cells that have lost their ability to use glucose (sugar) as a result of Alzheimer’s disease.
Status:
Possibly Marketed Outside US
Source:
M006
(2014)
Source URL:
First approved in 2002
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)