Details
Stereochemistry | ACHIRAL |
Molecular Formula | C4H5NO4S |
Molecular Weight | 163.152 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=CC(=O)NS(=O)(=O)O1
InChI
InChIKey=YGCFIWIQZPHFLU-UHFFFAOYSA-N
InChI=1S/C4H5NO4S/c1-3-2-4(6)5-10(7,8)9-3/h2H,1H3,(H,5,6)
Acesulfame is a non-nutritive sweetener Acesulfame potassium is a calorie-free artificial sweetener, also known as Acesulfame K or Ace K (K being the symbol for potassium), and marketed under the trade names Sunett and Sweet One. In the European Union, it is known under the E number (additive code) E950. It was discovered accidentally in 1967 by German chemist Karl Clauss at Hoechst AG (now Nutrinova). In chemical structure, acesulfame potassium is the potassium salt of 6-methyl-1,2,3- oxathiazine-4(3H)-one 2,2-dioxide. Acesulfame K has been approved for a variety of uses in more than 90 countries. In 1998, the FDA broadened the US approval of acesulfame K to allow its use in nonalcoholic beverages. It is often blended with sucralose and used to decrease the bitter aftertaste of aspartame. A wide range of low-calorie foods and drinks contain acesulfame K, including table-top sweeteners, chewing gum, jam, dairy products, frozen desserts, drinks and baked goods. Acesulfame K is not broken down when digested, nor is it stored in the body. After being consumed, it is quickly absorbed by the body and then rapidly excreted, unchanged.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL3594 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25019479 |
2.41 µM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Preventing | Acesulfame K Approved UseNonnutritive sweetener Launch Date1988 |
PubMed
Title | Date | PubMed |
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Calculation of the intake of three intense sweeteners in young insulin-dependent diabetics. | 2001 Jul |
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[Simultaneous determination of various food additives by high performance liquid chromatography]. | 2001 Mar |
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Determination of acesulfame and sucralose in oral electrolyte maintenance solution by liquid chromatography. | 2003 Jan-Feb |
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The erosive potential of some flavoured waters. | 2007 Jan |
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Detection of food additives by voltammetry at the liquid-liquid interface. | 2008 Jun 25 |
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Analysis and occurrence of seven artificial sweeteners in German waste water and surface water and in soil aquifer treatment (SAT). | 2009 Jul |
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Acute ingestion of a novel whey-derived peptide improves vascular endothelial responses in healthy individuals: a randomized, placebo controlled trial. | 2009 Jul 22 |
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Gain weight by "going diet?" Artificial sweeteners and the neurobiology of sugar cravings: Neuroscience 2010. | 2010 Jun |
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Performance of conventional multi-barrier drinking water treatment plants for the removal of four artificial sweeteners. | 2010 Jun |
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Polymorphism in acesulfame sweetener: structure-property and stability relationships of bending and brittle crystals. | 2010 May 28 |
Patents
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17046038
Acesulfame`s effect on the contractile response of isolated rat detrusor muscle strips was evaluated. The atropine-resistant response to EFS was marginally increased by acesulfame K 10(-6) M. Acesulfame K 10(-6) M increased the maximum contractile response to alpha,beta methylene ATP by 35% (+/-9.6%) (p<0.05) and to KCl by 12% (+/-3.1%) (p<0.01). Acesulfame K 10(-6) M increased the log EC(50) from -2.79 (+/-0.037) to -3.03 (+/-0.048, p<0.01).
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NCI_THESAURUS |
C283
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100000087935
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ACTIVE MOIETY
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