U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 111 - 120 of 129 results

Status:
US Previously Marketed
Source:
CAPSEBON by PITMAN MOORE
(1961)
Source URL:
First approved in 1958
Source:
Capsebon by Pitman-Moore (Dow Chem., USA)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Cadmium is a heavy metal that causes toxicity in humans and animals. Cadmium chloride is used due to its solubility in water and its ability to produce high concentrations of cadmium at the target site. Cadmium chloride is used in printing, photocopying, dyeing, analytical chemistry. Experiments on rodents have shown that this compound caused renal toxicity. Oxidative stress plays a key role in cadmium chloride-induced cyto/genotoxicity.
BUNAMIODYL is an cholecystographic agent which was used to aid the radiographic visualization of the gallbladder for detecting the presence of gallstones in cholelithiasis patients. It was withdrawn from the market due to nephropathy.
Status:
US Previously Marketed
First approved in 1958

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
First approved in 1958
Source:
Cothera by Ayerst
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

DIMETHOXANATE is a phenothiazine, which is used as a cough suppressant.
Status:
US Previously Marketed
Source:
Murel by Ayerst
(1958)
Source URL:
First approved in 1958
Source:
Murel by Ayerst
Source URL:

Class (Stereo):
CHEMICAL (MIXED)



Valethamate bromide ( sold under many brand names such as Epidosin, Dilaton, Valosin, Valamate, Osdil etc), a quarternary ammonium agent, has been used in augmentation of labor. Valethamate has antimuscarinic action and blocks cholinergic receptors in the ganglia. This action along with the direct action on the smooth muscles of the cervix is thought to help cervical dilatation during labor. Since it is not selective, it exerts anticholinergic side effects such as tachycardia, flushing, cotton mouth and photophobia due to mydriasis. Common side effects are palpitations, increased heart rate, arrhythmia, excessive thirst, reduced bronchial secretions, dry mouth, Photophobia, dry skin, loss of accommodation, slow heart rate, flushing.
Status:
US Previously Marketed
Source:
DEANER 100MG by RIKER
(1961)
Source URL:
First approved in 1958
Source:
Deaner by Riker
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

DEANOL is an inactive component of CERAVE® hydrocortisone anti-itch cream, which is used for temporarily relieve itching associated with minor skin irritations, inflammation, and rashes due to eczema, soaps, detergents, cosmetics, seborrheic dermatitis, psoriasis. DEANOL is also used as a food additive.
Status:
US Previously Marketed
First approved in 1958
Source:
Kantrex by Bristol
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Kanamycin A is aminoglycoside anti-bacterial agent. Active against many strains of Gram-negative bacteria and Gram-positive Staphylococcus aureus and epidermis. Some strains of Mycobacterium bacterium are sensitive. Most active in alkaline solution. It binds to bacterial ribosomes and reduces mRNA translation hence reduces protein biosynthesis. However, it also exhibits some toxic effects towards mammalian cells.
Status:
US Previously Marketed
Source:
ALUDROX SA AMBUTONIUM BROMIDE by WYETH
(1961)
Source URL:
First approved in 1958
Source:
Ambutonium Bromide by Wyeth
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Ambutonium is anticholinergic agent. It is a muscarinic antagonist. Ambutonium was used for the treatment of ulcerous disease and gastrointestinal disease in general.
Status:
US Previously Marketed
Source:
DEANER 100MG by RIKER
(1961)
Source URL:
First approved in 1958
Source:
Deaner by Riker
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

DEANOL is an inactive component of CERAVE® hydrocortisone anti-itch cream, which is used for temporarily relieve itching associated with minor skin irritations, inflammation, and rashes due to eczema, soaps, detergents, cosmetics, seborrheic dermatitis, psoriasis. DEANOL is also used as a food additive.
Status:
US Previously Marketed
Source:
Pentaiets by Merck Sharp & Dohme
(1958)
Source URL:
First approved in 1958
Source:
Pentaiets by Merck Sharp & Dohme
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Showing 111 - 120 of 129 results