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Approval Year

1926

5

Unknown

139,593

1921

1,467

2020

742

2013

596

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Development Status

US Previously Marketed

5

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Primary Target

Acetylcholinesterase

2

Muscarinic receptor M2 and M3

2

Arachidonate 5-lipoxygenase

1

Parainfluenza virus type 3

1

Tyrosinase

1

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Highest Phase

Approved

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Condition

Travel sickness

2

Unknown

2

Hyperpigmentation

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Respiratory tract infections

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Sore throat

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Treatment Modality

Preventing

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Curative

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Primary

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Originator

Polonovski, M.|Polonovski, M.

2

Leonard, V.

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Chemical

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CAS

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EPA CompTox

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MERCK INDEX

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ECHA (EC/EINECS)

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ATC Level 1

RESPIRATORY SYSTEM

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THROAT PREPARATIONS

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ATC Level 3

THROAT PREPARATIONS

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ATC Level 4

Antiseptics

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Principal Form

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Salts, Hydrates, Esters, etc.

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Showing 1 - 5 of 5 results

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PAMAQUINE

99QVL5KPSU

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Status:

US Previously Marketed

First marketed in 1926

Class (Stereo):

CHEMICAL (RACEMIC)

The discovery of pamaquine, developed by replacing one of the methyl groups of methylene blue by a dialkylaminoalkyl chain, was a landmark in the design of drugs for malaria. It is closely related to primaquine. The administration of pamaquine during...

the incubation period delayed but did not prevent primary attacks of a New Guinea strain of Plasmodium vivax malaria. Hemolytic anemia after administration of the antimalarial drug pamaquine was reported in patients with Glucose-6-phosphate dehydrogenase (G6PD) deficiency. Pamaquine itself could not be used clinically due to high toxicity.

HEXYLRESORCINOL

R9QTB5E82N

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Status:

US Previously Marketed

First marketed in 1926

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Arachidonate 5-lipoxygenase

Parainfluenza virus type 3

Conditions:

Respiratory tract infections

Hyperpigmentation

Hexylresorcinol is an organic compound with local anaesthetic, antiseptic and anthelmintic properties. It is available for use topically on small skin infections, or as an ingredient in throat lozenges. Hexylresorcinol may be used as a cosmetic bioci...

de. Hexylresorcinol was introduced by Leonard as a urinary antiseptic with great possibilities. Used in alkaline solution it promised success in experiments in vitro. Boots Hexylresorcinol 2.4mg Throat Lozenges, marketed in UK, are used to relieve sore throat pain. Hexylresorcinol has being shown to be useful for the topical treatment of hyperpigmentation.

SCOPOLAMINE N-OXIDE

0I3054Z711

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Status:

US Previously Marketed

First marketed in 1926

Class (Stereo):

CHEMICAL (EPIMERIC)

Targets:

Muscarinic receptor M2 and M3

Acetylcholinesterase

Conditions:

Travel sickness

Scopolamine Aminoxide Hydrobromide is one of Scopolamine metabolites, with remarkable Acetylcholinesterase inhibitory activity.

PAMAQUINE NAPHTHOATE

96Y4A9AODB

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Status:

US Previously Marketed

First marketed in 1926

Class (Stereo):

CHEMICAL (RACEMIC)

The discovery of pamaquine, developed by replacing one of the methyl groups of methylene blue by a dialkylaminoalkyl chain, was a landmark in the design of drugs for malaria. It is closely related to primaquine. The administration of pamaquine during...

the incubation period delayed but did not prevent primary attacks of a New Guinea strain of Plasmodium vivax malaria. Hemolytic anemia after administration of the antimalarial drug pamaquine was reported in patients with Glucose-6-phosphate dehydrogenase (G6PD) deficiency. Pamaquine itself could not be used clinically due to high toxicity.

SCOPOLAMINE N-OXIDE HYDROBROMIDE

7E0GR5N4K8

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Status:

US Previously Marketed

First marketed in 1926

Class (Stereo):

CHEMICAL (EPIMERIC)

Targets:

Muscarinic receptor M2 and M3

Acetylcholinesterase

Conditions:

Travel sickness

Scopolamine Aminoxide Hydrobromide is one of Scopolamine metabolites, with remarkable Acetylcholinesterase inhibitory activity.

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