Details
| Stereochemistry | EPIMERIC |
| Molecular Formula | C17H21NO5.BrH |
| Molecular Weight | 400.264 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 6 / 7 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Br.[H][C@@]12O[C@]1([H])[C@H]3C[C@H](C[C@@H]2[N@@+]3(C)[O-])OC(=O)[C@H](CO)C4=CC=CC=C4
InChI
InChIKey=MGNNYKWRWHQLCR-FDJOISAFSA-N
InChI=1S/C17H21NO5.BrH/c1-18(21)13-7-11(8-14(18)16-15(13)23-16)22-17(20)12(9-19)10-5-3-2-4-6-10;/h2-6,11-16,19H,7-9H2,1H3;1H/t11-,12-,13-,14+,15-,16+,18?;/m1./s1
DescriptionSources: https://books.google.ru/books?id=mDLYCQAAQBAJ&pg=PA1258&lpg=PA1258&dq=HYOSCINE+N-OXIDE+is+used&source=bl&ots=RU3LXkZpto&sig=87LQi9-Pip7ucsNJZF3j1CRvUBw&hl=ru&sa=X&ved=0ahUKEwj9hdiVl6jPAhUBuBQKHZAyC4M4ChDoAQgoMAI#v=onepage&q=HYOSCINE%20N-OXIDE%20is%20used&f=falsehttps://www.ncbi.nlm.nih.gov/pubmed/18970269Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/21006683 | http://journals.tubitak.gov.tr/chem/issues/kim-12-36-2/kim-36-2-5-1108-59.pdf | https://www.ncbi.nlm.nih.gov/pubmed/18218192
Sources: https://books.google.ru/books?id=mDLYCQAAQBAJ&pg=PA1258&lpg=PA1258&dq=HYOSCINE+N-OXIDE+is+used&source=bl&ots=RU3LXkZpto&sig=87LQi9-Pip7ucsNJZF3j1CRvUBw&hl=ru&sa=X&ved=0ahUKEwj9hdiVl6jPAhUBuBQKHZAyC4M4ChDoAQgoMAI#v=onepage&q=HYOSCINE%20N-OXIDE%20is%20used&f=falsehttps://www.ncbi.nlm.nih.gov/pubmed/18970269
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/21006683 | http://journals.tubitak.gov.tr/chem/issues/kim-12-36-2/kim-36-2-5-1108-59.pdf | https://www.ncbi.nlm.nih.gov/pubmed/18218192
Scopolamine Aminoxide Hydrobromide is one of Scopolamine metabolites, with remarkable Acetylcholinesterase inhibitory activity.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The comparative toxicity and effectiveness of scopolamine hydrobromide (C17H21O4N.HBr) and scopolamine aminoxide hydrobromide (C17H21O5N HBr). | 1945 |
|
| Metabolic N-oxidation of atropine, hyoscine and the corresponding nor-alkaloids by guinea-pig liver microsomal preparations. | 1976 Sep |
|
| Affinities of the protonated and non-protonated forms of hyoscine and hyoscine N-oxide for muscarinic receptors of the guinea-pig ileum and a comparison of their size in solution with that of atropine. | 1981 Apr |
Patents
Sample Use Guides
https://books.google.ru/books?id=mDLYCQAAQBAJ&pg=PA1258&lpg=PA1258&dq=HYOSCINE+N-OXIDE+is+used&source=bl&ots=RU3LXkZpto&sig=87LQi9-Pip7ucsNJZF3j1CRvUBw&hl=ru&sa=X&ved=0ahUKEwj9hdiVl6jPAhUBuBQKHZAyC4M4ChDoAQgoMAI#v=onepage&q=HYOSCINE%20N-OXIDE%20is%20used&f=false
Route of Administration:
Oral
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PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
