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Details

Stereochemistry EPIMERIC
Molecular Formula C17H21NO5.BrH
Molecular Weight 400.264
Optical Activity UNSPECIFIED
Defined Stereocenters 6 / 7
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SCOPOLAMINE N-OXIDE HYDROBROMIDE

SMILES

Br.[H][C@@]12O[C@]1([H])[C@H]3C[C@H](C[C@@H]2[N@@+]3(C)[O-])OC(=O)[C@H](CO)C4=CC=CC=C4

InChI

InChIKey=MGNNYKWRWHQLCR-FDJOISAFSA-N
InChI=1S/C17H21NO5.BrH/c1-18(21)13-7-11(8-14(18)16-15(13)23-16)22-17(20)12(9-19)10-5-3-2-4-6-10;/h2-6,11-16,19H,7-9H2,1H3;1H/t11-,12-,13-,14+,15-,16+,18?;/m1./s1

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/21006683 | http://journals.tubitak.gov.tr/chem/issues/kim-12-36-2/kim-36-2-5-1108-59.pdf | https://www.ncbi.nlm.nih.gov/pubmed/18218192

Scopolamine Aminoxide Hydrobromide is one of Scopolamine metabolites, with remarkable Acetylcholinesterase inhibitory activity.

Originator

Sources: Compt. rend. Volume 180, Pages 1755-7, Journal, 1925

Approval Year

Targets

Targets

Conditions
PubMed

PubMed

TitleDatePubMed
The comparative toxicity and effectiveness of scopolamine hydrobromide (C17H21O4N.HBr) and scopolamine aminoxide hydrobromide (C17H21O5N HBr).
1945
Metabolic N-oxidation of atropine, hyoscine and the corresponding nor-alkaloids by guinea-pig liver microsomal preparations.
1976 Sep
Affinities of the protonated and non-protonated forms of hyoscine and hyoscine N-oxide for muscarinic receptors of the guinea-pig ileum and a comparison of their size in solution with that of atropine.
1981 Apr
Patents

Patents

Sample Use Guides

https://books.google.ru/books?id=mDLYCQAAQBAJ&pg=PA1258&lpg=PA1258&dq=HYOSCINE+N-OXIDE+is+used&source=bl&ots=RU3LXkZpto&sig=87LQi9-Pip7ucsNJZF3j1CRvUBw&hl=ru&sa=X&ved=0ahUKEwj9hdiVl6jPAhUBuBQKHZAyC4M4ChDoAQgoMAI#v=onepage&q=HYOSCINE%20N-OXIDE%20is%20used&f=false
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
SCOPOLAMINE N-OXIDE HYDROBROMIDE
HSDB   MI  
Common Name English
SCOPOLAMINE N-OXIDE HYDROBROMIDE [HSDB]
Common Name English
NSC-61807
Code English
SCOPOLAMINE N-OXIDE HYDROBROMIDE [MI]
Common Name English
SCOPOLAMINE N-OXIDE HBR
Common Name English
Scopolamine aminoxide hydrobromide [WHO-DD]
Common Name English
SCOPOLAMINE AMINOXIDE HYDROBROMIDE
WHO-DD  
Common Name English
SCOPOLAMINE AMINOXIDE HBR
Common Name English
Code System Code Type Description
HSDB
6105
Created by admin on Fri Dec 15 15:47:14 GMT 2023 , Edited by admin on Fri Dec 15 15:47:14 GMT 2023
PRIMARY
SMS_ID
100000078421
Created by admin on Fri Dec 15 15:47:14 GMT 2023 , Edited by admin on Fri Dec 15 15:47:14 GMT 2023
PRIMARY
FDA UNII
7E0GR5N4K8
Created by admin on Fri Dec 15 15:47:14 GMT 2023 , Edited by admin on Fri Dec 15 15:47:14 GMT 2023
PRIMARY
EPA CompTox
DTXSID2045101
Created by admin on Fri Dec 15 15:47:14 GMT 2023 , Edited by admin on Fri Dec 15 15:47:14 GMT 2023
PRIMARY
EVMPD
SUB15206MIG
Created by admin on Fri Dec 15 15:47:14 GMT 2023 , Edited by admin on Fri Dec 15 15:47:14 GMT 2023
PRIMARY
ECHA (EC/EINECS)
228-066-8
Created by admin on Fri Dec 15 15:47:14 GMT 2023 , Edited by admin on Fri Dec 15 15:47:14 GMT 2023
PRIMARY
CAS
6106-81-6
Created by admin on Fri Dec 15 15:47:14 GMT 2023 , Edited by admin on Fri Dec 15 15:47:14 GMT 2023
PRIMARY
NSC
61807
Created by admin on Fri Dec 15 15:47:14 GMT 2023 , Edited by admin on Fri Dec 15 15:47:14 GMT 2023
PRIMARY
MERCK INDEX
m9814
Created by admin on Fri Dec 15 15:47:14 GMT 2023 , Edited by admin on Fri Dec 15 15:47:14 GMT 2023
PRIMARY Merck Index