Details
Stereochemistry | ACHIRAL |
Molecular Formula | C12H18O2 |
Molecular Weight | 194.2701 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCCC1=CC=C(O)C=C1O
InChI
InChIKey=WFJIVOKAWHGMBH-UHFFFAOYSA-N
InChI=1S/C12H18O2/c1-2-3-4-5-6-10-7-8-11(13)9-12(10)14/h7-9,13-14H,2-6H2,1H3
DescriptionCurator's Comment: Description was created based on several sources, including https://www.drugs.com/international/hexylresorcinol.html
Curator's Comment: Description was created based on several sources, including https://www.drugs.com/international/hexylresorcinol.html
Hexylresorcinol is an organic compound with local anaesthetic, antiseptic and anthelmintic properties. It is available for use topically on small skin infections, or as an ingredient in throat lozenges. Hexylresorcinol may be used as a cosmetic biocide. Hexylresorcinol was introduced by Leonard as a urinary antiseptic with great possibilities. Used in alkaline solution it promised success in experiments in vitro. Boots Hexylresorcinol 2.4mg Throat Lozenges, marketed in UK, are used to relieve sore throat pain. Hexylresorcinol has being shown to be useful for the topical treatment of hyperpigmentation.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL215 Sources: http://www.ncbi.nlm.nih.gov/pubmed/23871907 |
2.8 µM [IC50] | ||
Target ID: Parainfluenza virus type 3 Sources: http://www.ncbi.nlm.nih.gov/pubmed/26408353 |
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Target ID: CHEMBL1973 Sources: http://www.ncbi.nlm.nih.gov/pubmed/23205541 |
94.0 µM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Boots Hexylresorcinol 2.4mg Throat Lozenges Blackcurrant Approved UseAs an antiseptic and local anaesthetic for the relief of sore throat and its associated pain. Launch Date1.1434176E12 |
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Primary | Unknown Approved UseUnknown |
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Curative | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
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[Sensitization to resorcinol in a prescription verrucide preparation: unusual systemic clinical features and prevalence]. | 2001 May |
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[Synthesis of anabiosis autoinducers in non-spore-forming bacteria as a mechanism regulating their activity in soil and subsoil sedimentary rocks]. | 2001 Sep-Oct |
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Polyphenol oxidases from latex of Hevea brasiliensis: purification and characterization. | 2002 Sep |
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Effects of resveratrol and 4-hexylresorcinol on hydrogen peroxide-induced oxidative DNA damage in human lymphocytes. | 2003 May |
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[Induction of SOS-response of cells exposed to autoregulatory factors of microorganisms]. | 2003 Sep |
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Inhibitory effects of hexylresorcinol and dodecylresorcinol on mushroom (Agaricus bisporus) tyrosinase. | 2004 Feb |
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[Effect of a chemical analogue of autoinducers of microbial anabiosis on the Ca2+ response of mycelial fungi]. | 2004 Nov-Dec |
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[Hexylresorcinol induces chromosome aberrations in mouse peripheral blood cells]. | 2005 Aug |
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[Determination of 4-hexylresorcinol residues in prawns and crabs]. | 2005 Dec |
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Role of sulfites and 4-hexylresorcinol in microbial growth and melanosis prevention of deepwater pink shrimp (Parapenaeus longirostris) using a controlled atmosphere. | 2005 Jan |
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Management of urinary tract infections: historical perspective and current strategies: Part 1--Before antibiotics. | 2005 Jan |
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[Effect of alkylhydroxybenzenes, microbial anabiosis inducers, on the structural organization of Pseudomonas aurantiaca DNA and on phenotypic dissociation induction]. | 2005 Mar-Apr |
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[Mechanisms of interaction between DNA and chemical analogues of microbial anabiosis autoinducers]. | 2005 Sep-Oct |
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Use of experimental design methodology to prepare Maillard reaction products from glucose and cysteine inhibitors of polyphenol oxidase from eggplant (Solanum melongena). | 2006 Jul 12 |
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[Non-species-specific effects of unacylated homoserine lactone and hexylresorcinol, low molecular weight autoregulators, on the growth and development of bacteria]. | 2006 Jul-Aug |
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[A comparative study of the inducing effect of homoserine lactone and hexylresorcinol on phenotypic dissociation in bacteria]. | 2006 Jul-Aug |
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Co-occurrence of the multicopper oxidases tyrosinase and laccase in lichens in sub-order peltigerineae. | 2006 Nov |
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In vitro anthelmintic activity of Melia azedarach naturalized in Argentina. | 2006 Nov |
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[Long-term preservation of DNA in aqueous solutions in the presence of the chemical analogues of microbial autoregulators]. | 2006 Sep-Oct |
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[Influence of chemical analogues of microbial autoregulators on the sensitivity of DNA to UV radiation]. | 2006 Sep-Oct |
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Oxyresveratrol as an antibrowning agent for cloudy apple juices and fresh-cut apples. | 2007 Apr 4 |
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[IR spectroscopic research on the impact of chemical analogues of autoregulatory d1 factors of microorganisms on structural changes in DNA]. | 2007 May-Jun |
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Browning prevention by ascorbic acid and 4-hexylresorcinol: different mechanisms of action on polyphenol oxidase in the presence and in the absence of substrates. | 2007 Nov |
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Ascorbic acid and 4-hexylresorcinol effects on pear PPO and PPO catalyzed browning reaction. | 2007 Oct |
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Effect of pyrophosphate and 4-hexylresorcinol pretreatment on quality of refrigerated white shrimp (Litopenaeus vannamei) kept under modified atmosphere packaging. | 2008 Apr |
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Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism. | 2008 Apr |
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Effect of natural antibrowning agents on color and related enzymes in fresh-cut Fuji apples as an alternative to the use of ascorbic acid. | 2008 Aug |
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Solvent effects on the spectroscopic properties of 4-hexylresorcinol. | 2008 Nov 15 |
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[Modification of bacterial population structure on anti-lysozyme activity under the influence of hexylresorcinol]. | 2008 Nov-Dec |
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Harnessing gene expression to identify the genetic basis of drug resistance. | 2009 |
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Topical antiseptics for the treatment of sore throat block voltage-gated neuronal sodium channels in a local anaesthetic-like manner. | 2009 Aug |
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Identification of xenoestrogens in food additives by an integrated in silico and in vitro approach. | 2009 Jan |
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[Effect of a synthetic analogue of bacterial anabiosis autoinducers hexylresorcinol on the stability of membrane structures]. | 2009 Mar-Apr |
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Variations in IC(50) values with purity of mushroom tyrosinase. | 2009 Sep 2 |
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First evidence of laccase activity in the Pacific oyster Crassostrea gigas. | 2010 Apr |
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4-Hexylresorcinol inhibits transglutaminase-2 activity and has synergistic effects along with cisplatin in KB cells. | 2011 Jun |
Sample Use Guides
For oral administration.
Adults, the elderly and children 6 years and over: One lozenge dissolved slowly in
the mouth every three hours or as required.
Do not take more than 12 lozenges in 24 hours.
Do not give to children under 6 years.
Route of Administration:
Oral
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/27198070
TNF-α protein levels were reduced following treatment with Hexylresorcinol at concentrations between 1 and 10μg/mL in RAW264.7 cells.
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WHO-VATC |
QR02AA12
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NCI_THESAURUS |
C28394
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EPA PESTICIDE CODE |
71403
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WHO-ATC |
R02AA12
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JECFA EVALUATION |
INS-586
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205-257-4
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5321
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566
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D006604
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m6018
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3610
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136-77-6
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R9QTB5E82N
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1374
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CHEMBL443605
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C29092
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SUB14103MIG
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HEXYLRESORCINOL
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100000077923
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)