U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C12H18O2
Molecular Weight 194.2701
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HEXYLRESORCINOL

SMILES

CCCCCCC1=CC=C(O)C=C1O

InChI

InChIKey=WFJIVOKAWHGMBH-UHFFFAOYSA-N
InChI=1S/C12H18O2/c1-2-3-4-5-6-10-7-8-11(13)9-12(10)14/h7-9,13-14H,2-6H2,1H3

HIDE SMILES / InChI

Description

Hexylresorcinol is an organic compound with local anaesthetic, antiseptic and anthelmintic properties. It is available for use topically on small skin infections, or as an ingredient in throat lozenges. Hexylresorcinol may be used as a cosmetic biocide. Hexylresorcinol was introduced by Leonard as a urinary antiseptic with great possibilities. Used in alkaline solution it promised success in experiments in vitro. Boots Hexylresorcinol 2.4mg Throat Lozenges, marketed in UK, are used to relieve sore throat pain. Hexylresorcinol has being shown to be useful for the topical treatment of hyperpigmentation.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
2.8 µM [IC50]
94.0 µM [IC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Boots Hexylresorcinol 2.4mg Throat Lozenges Blackcurrant
Primary
Unknown
Curative
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
For oral administration. Adults, the elderly and children 6 years and over: One lozenge dissolved slowly in the mouth every three hours or as required. Do not take more than 12 lozenges in 24 hours. Do not give to children under 6 years.
Route of Administration: Oral
In Vitro Use Guide
TNF-α protein levels were reduced following treatment with Hexylresorcinol at concentrations between 1 and 10μg/mL in RAW264.7 cells.