BAMIFYLLINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H27N5O3
Molecular Weight	385.4601
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN(CCO)CCN1C(CC2=CC=CC=C2)=NC3=C1C(=O)N(C)C(=O)N3C

InChI

InChIKey=VVUYEFBRTFASAH-UHFFFAOYSA-N

InChI=1S/C20H27N5O3/c1-4-24(12-13-26)10-11-25-16(14-15-8-6-5-7-9-15)21-18-17(25)19(27)23(3)20(28)22(18)2/h5-9,26H,4,10-14H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C20H27N5O3
Molecular Weight	385.4601
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2314621 | https://www.ncbi.nlm.nih.gov/pubmed/8781823

Bamifylline (or bamiphylline), a selective antagonist of the A1 adenosine receptor, was studied in the therapy of asthmatic syndromes.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Adenosine receptor A1 4 Target ID: P30542 Gene ID: 134.0 Gene Symbol: ADORA1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/8781823	Antagonist 2778

PubMed

Title	Date	PubMed
Bamiphylline improves exercise-induced myocardial ischemia through a novel mechanism of action.	1993 Aug	8339412
Acute generalized exanthematous pustulosis induced by ingestion of bamifylline.	2002 Nov	12482053
Tumor necrosis factor-alpha in whole blood cultures of preeclamptic patients and healthy pregnant and nonpregnant women.	2004	15617632
Isolation and culture of biliary epithelial cells from bile duct remnants of patients with biliary atresia.	2004 Sep	15378328
UC blood infection with clinical strains of Mycobacterium tuberculosis: a novel model.	2007	17852201
Catecholaminergic neuron survival: getting hooked on GDNF.	2008 Jul	18575468
In human endothelial cells rapamycin causes mTORC2 inhibition and impairs cell viability and function.	2008 Jun 1	18250144
Single channel studies of the ATP-regulated potassium channel in brain mitochondria.	2009 Aug	19821034

Patents

Sample Use Guides

In Vivo Use Guide

600 mg b.d. for 15 days

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:26:29 GMT 2023` Edited by `admin` on `Fri Dec 15 15:26:29 GMT 2023`
Record UNII	ZTY15D026H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BAMIFYLLINE

Official Name

English

8-BENZYL-7-(2-(ETHYL(2-HYDROXYETHYL)AMINO)ETHYL)THEOPHYLLINE

Systematic Name

English

BAMIFYLLINE [MI]

Common Name

English

Bamifylline [WHO-DD]

Common Name

English

BAX-2739Z FREE BASE

Code

English

AC-3810 FREE BASE

Code

English

bamifylline [INN]

Common Name

English

1H-PURINE-2,6-DIONE, 7-(2-(ETHYL(2-HYDROXYETHYL)AMINO)ETHYL)-3,7-DIHYDRO-1,3-DIMETHYL-8-(PHENYLMETHYL)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C319