BAMIFYLLINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H27N5O3
Molecular Weight	385.4601
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN(CCO)CCN1C(CC2=CC=CC=C2)=NC3=C1C(=O)N(C)C(=O)N3C

InChI

InChIKey=VVUYEFBRTFASAH-UHFFFAOYSA-N

InChI=1S/C20H27N5O3/c1-4-24(12-13-26)10-11-25-16(14-15-8-6-5-7-9-15)21-18-17(25)19(27)23(3)20(28)22(18)2/h5-9,26H,4,10-14H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C20H27N5O3
Molecular Weight	385.4601
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2314621 | https://www.ncbi.nlm.nih.gov/pubmed/8781823

Bamifylline (or bamiphylline), a selective antagonist of the A1 adenosine receptor, was studied in the therapy of asthmatic syndromes.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Adenosine receptor A1 4 Target ID: P30542 Gene ID: 134.0 Gene Symbol: ADORA1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/8781823	Antagonist 2778

PubMed

Title	Date	PubMed
Bamiphylline improves exercise-induced myocardial ischemia through a novel mechanism of action.	1993 Aug	8339412
Acute generalized exanthematous pustulosis induced by ingestion of bamifylline.	2002 Nov	12482053
Tumor necrosis factor-alpha in whole blood cultures of preeclamptic patients and healthy pregnant and nonpregnant women.	2004	15617632
UC blood infection with clinical strains of Mycobacterium tuberculosis: a novel model.	2007	17852201
Catecholaminergic neuron survival: getting hooked on GDNF.	2008 Jul	18575468
In human endothelial cells rapamycin causes mTORC2 inhibition and impairs cell viability and function.	2008 Jun 1	18250144
Single channel studies of the ATP-regulated potassium channel in brain mitochondria.	2009 Aug	19821034

Patents

Sample Use Guides

In Vivo Use Guide

600 mg b.d. for 15 days

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:26:29 GMT 2023` Edited by `admin` on `Fri Dec 15 15:26:29 GMT 2023`
Record UNII	ZTY15D026H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BAMIFYLLINE

Official Name

English

8-BENZYL-7-(2-(ETHYL(2-HYDROXYETHYL)AMINO)ETHYL)THEOPHYLLINE

Systematic Name

English

BAMIFYLLINE [MI]

Common Name

English

Bamifylline [WHO-DD]

Common Name

English

BAX-2739Z FREE BASE

Code

English

AC-3810 FREE BASE

Code

English

bamifylline [INN]

Common Name

English

1H-PURINE-2,6-DIONE, 7-(2-(ETHYL(2-HYDROXYETHYL)AMINO)ETHYL)-3,7-DIHYDRO-1,3-DIMETHYL-8-(PHENYLMETHYL)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C319