BAMIFYLLINE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H27N5O3.ClH
Molecular Weight	421.921
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCN(CCO)CCN1C(CC2=CC=CC=C2)=NC3=C1C(=O)N(C)C(=O)N3C

InChI

InChIKey=PDBXHPORMXSXKO-UHFFFAOYSA-N

InChI=1S/C20H27N5O3.ClH/c1-4-24(12-13-26)10-11-25-16(14-15-8-6-5-7-9-15)21-18-17(25)19(27)23(3)20(28)22(18)2;/h5-9,26H,4,10-14H2,1-3H3;1H

HIDE SMILES / InChI

Molecular Formula	C20H27N5O3
Molecular Weight	385.4601
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2314621 | https://www.ncbi.nlm.nih.gov/pubmed/8781823

Bamifylline (or bamiphylline), a selective antagonist of the A1 adenosine receptor, was studied in the therapy of asthmatic syndromes.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Adenosine receptor A1 4 Target ID: P30542 Gene ID: 134.0 Gene Symbol: ADORA1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/8781823	Antagonist 2849

PubMed

Title	Date	PubMed
Single channel studies of the ATP-regulated potassium channel in brain mitochondria.	2009-08	19821034
Catecholaminergic neuron survival: getting hooked on GDNF.	2008-07	18575468
In human endothelial cells rapamycin causes mTORC2 inhibition and impairs cell viability and function.	2008-06-01	18250144
UC blood infection with clinical strains of Mycobacterium tuberculosis: a novel model.	2007	17852201
Isolation and culture of biliary epithelial cells from bile duct remnants of patients with biliary atresia.	2004-09	15378328
Tumor necrosis factor-alpha in whole blood cultures of preeclamptic patients and healthy pregnant and nonpregnant women.	2004	15617632
Acute generalized exanthematous pustulosis induced by ingestion of bamifylline.	2002-11	12482053
Bamiphylline improves exercise-induced myocardial ischemia through a novel mechanism of action.	1993-08	8339412

Patents

Sample Use Guides

In Vivo Use Guide

600 mg b.d. for 15 days

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:45:14 GMT 2025` Edited by `admin` on `Mon Mar 31 17:45:14 GMT 2025`
Record UNII	66466QLM3S
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BAMIFYLLINE HYDROCHLORIDE

Official Name

English

8102 CB

Preferred Name

English

1H-PURINE-2,6-DIONE, 7-(2-(ETHYL(2-HYDROXYETHYL)AMINO)ETHYL)-3,7-DIHYDRO-1,3-DIMETHYL-8-(PHENYLMETHYL)-, HYDROCHLORIDE (1:1)

Systematic Name

English

8102-CB

Code

English

AC 3810

Code

English

1H-PURINE-2,6-DIONE, 7-(2-(ETHYL(2-HYDROXYETHYL)AMINO)ETHYL)-3,7-DIHYDRO-1,3-DIMETHYL-8-(PHENYLMETHYL)-, MONOHYDROCHLORIDE

Systematic Name

English

BAX-2739Z

Code

English

8-Benzyl-7-[2-[ethyl(2-hydroxyethyl)amino]ethyl]theophylline monohydrochloride

Systematic Name

English

BAX 2739Z

Code

English

BAMIFYLLINE HYDROCHLORIDE [USAN]

Common Name

English

BAMIFYLLINE HCL

Common Name

English

AC-3810

Code

English

BAMIFYLLINE HYDROCHLORIDE [MART.]

Common Name

English

Bamifylline hydrochloride [WHO-DD]

Common Name

English

BAMIFYLLINE HYDROCHLORIDE [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C319