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Details

Stereochemistry ACHIRAL
Molecular Formula C20H27N5O3.ClH
Molecular Weight 421.921
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BAMIFYLLINE HYDROCHLORIDE

SMILES

Cl.CCN(CCO)CCN1C(CC2=CC=CC=C2)=NC3=C1C(=O)N(C)C(=O)N3C

InChI

InChIKey=PDBXHPORMXSXKO-UHFFFAOYSA-N
InChI=1S/C20H27N5O3.ClH/c1-4-24(12-13-26)10-11-25-16(14-15-8-6-5-7-9-15)21-18-17(25)19(27)23(3)20(28)22(18)2;/h5-9,26H,4,10-14H2,1-3H3;1H

HIDE SMILES / InChI
Molecular Formula C20H27N5O3
Molecular Weight 385.4601
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Bamifylline (or bamiphylline), a selective antagonist of the A1 adenosine receptor, was studied in the therapy of asthmatic syndromes.

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Adenosine receptor A1
4
Target ID: P30542
Gene ID: 134.0
Gene Symbol: ADORA1
Target Organism: Homo sapiens (Human)
Antagonist
2778
PubMed

PubMed

TitleDatePubMed
Bamiphylline improves exercise-induced myocardial ischemia through a novel mechanism of action.
1993 Aug
Acute generalized exanthematous pustulosis induced by ingestion of bamifylline.
2002 Nov
Tumor necrosis factor-alpha in whole blood cultures of preeclamptic patients and healthy pregnant and nonpregnant women.
2004
Isolation and culture of biliary epithelial cells from bile duct remnants of patients with biliary atresia.
2004 Sep
UC blood infection with clinical strains of Mycobacterium tuberculosis: a novel model.
2007
Catecholaminergic neuron survival: getting hooked on GDNF.
2008 Jul
In human endothelial cells rapamycin causes mTORC2 inhibition and impairs cell viability and function.
2008 Jun 1
Single channel studies of the ATP-regulated potassium channel in brain mitochondria.
2009 Aug
Patents

Patents

JP2002541233A
400

Sample Use Guides

In Vivo Use Guide
600 mg b.d. for 15 days
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:04:06 GMT 2023
Edited
by admin
on Fri Dec 15 15:04:06 GMT 2023
Record UNII
66466QLM3S
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BAMIFYLLINE HYDROCHLORIDE
MART.   MI   USAN   WHO-DD  
USAN  
Official Name English
1H-PURINE-2,6-DIONE, 7-(2-(ETHYL(2-HYDROXYETHYL)AMINO)ETHYL)-3,7-DIHYDRO-1,3-DIMETHYL-8-(PHENYLMETHYL)-, HYDROCHLORIDE (1:1)
Systematic Name English
8102-CB
Code English
AC 3810
Code English
1H-PURINE-2,6-DIONE, 7-(2-(ETHYL(2-HYDROXYETHYL)AMINO)ETHYL)-3,7-DIHYDRO-1,3-DIMETHYL-8-(PHENYLMETHYL)-, MONOHYDROCHLORIDE
Systematic Name English
BAX-2739Z
Code English
8-Benzyl-7-[2-[ethyl(2-hydroxyethyl)amino]ethyl]theophylline monohydrochloride
Systematic Name English
BAX 2739Z
Code English
8102 CB
Code English
BAMIFYLLINE HYDROCHLORIDE [USAN]
Common Name English
BAMIFYLLINE HCL
Common Name English
AC-3810
Code English
BAMIFYLLINE HYDROCHLORIDE [MART.]
Common Name English
Bamifylline hydrochloride [WHO-DD]
Common Name English
BAMIFYLLINE HYDROCHLORIDE [MI]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C319
Created by admin on Fri Dec 15 15:04:06 GMT 2023 , Edited by admin on Fri Dec 15 15:04:06 GMT 2023
Code System Code Type Description
ECHA (EC/EINECS)
243-967-6
Created by admin on Fri Dec 15 15:04:06 GMT 2023 , Edited by admin on Fri Dec 15 15:04:06 GMT 2023
PRIMARY
CAS
20684-06-4
Created by admin on Fri Dec 15 15:04:06 GMT 2023 , Edited by admin on Fri Dec 15 15:04:06 GMT 2023
PRIMARY
PUBCHEM
68549
Created by admin on Fri Dec 15 15:04:06 GMT 2023 , Edited by admin on Fri Dec 15 15:04:06 GMT 2023
PRIMARY
EPA CompTox
DTXSID4048721
Created by admin on Fri Dec 15 15:04:06 GMT 2023 , Edited by admin on Fri Dec 15 15:04:06 GMT 2023
PRIMARY
SMS_ID
100000091601
Created by admin on Fri Dec 15 15:04:06 GMT 2023 , Edited by admin on Fri Dec 15 15:04:06 GMT 2023
PRIMARY
FDA UNII
66466QLM3S
Created by admin on Fri Dec 15 15:04:06 GMT 2023 , Edited by admin on Fri Dec 15 15:04:06 GMT 2023
PRIMARY
DRUG BANK
DBSALT002675
Created by admin on Fri Dec 15 15:04:06 GMT 2023 , Edited by admin on Fri Dec 15 15:04:06 GMT 2023
PRIMARY
RXCUI
236152
Created by admin on Fri Dec 15 15:04:06 GMT 2023 , Edited by admin on Fri Dec 15 15:04:06 GMT 2023
PRIMARY RxNorm
NCI_THESAURUS
C76574
Created by admin on Fri Dec 15 15:04:06 GMT 2023 , Edited by admin on Fri Dec 15 15:04:06 GMT 2023
PRIMARY
MERCK INDEX
m2218
Created by admin on Fri Dec 15 15:04:06 GMT 2023 , Edited by admin on Fri Dec 15 15:04:06 GMT 2023
PRIMARY Merck Index
MESH
C006683
Created by admin on Fri Dec 15 15:04:06 GMT 2023 , Edited by admin on Fri Dec 15 15:04:06 GMT 2023
PRIMARY
ChEMBL
CHEMBL2110760
Created by admin on Fri Dec 15 15:04:06 GMT 2023 , Edited by admin on Fri Dec 15 15:04:06 GMT 2023
PRIMARY
EVMPD
SUB12981MIG
Created by admin on Fri Dec 15 15:04:06 GMT 2023 , Edited by admin on Fri Dec 15 15:04:06 GMT 2023
PRIMARY
Related Record Type Details
Structure of BAMIFYLLINE
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of BAMIFYLLINE
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