Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C17H12F3NO4 |
| Molecular Weight | 351.2767 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC=C(CN2C(=O)C(=O)C3=CC(OC(F)(F)F)=CC=C23)C=C1
InChI
InChIKey=CKLGZXFOLMHCMC-UHFFFAOYSA-N
InChI=1S/C17H12F3NO4/c1-24-11-4-2-10(3-5-11)9-21-14-7-6-12(25-17(18,19)20)8-13(14)15(22)16(21)23/h2-8H,9H2,1H3
| Molecular Formula | C17H12F3NO4 |
| Molecular Weight | 351.2767 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Simultaneous activation of mGlu2 and muscarinic receptors reverses MK-801-induced cognitive decline in rodents. | 2020-09-01 |
|
| Simultaneous activation of muscarinic and GABAB receptors as a bidirectional target for novel antipsychotics. | 2019-02-01 |
|
| M5 receptor activation produces opposing physiological outcomes in dopamine neurons depending on the receptor's location. | 2014-02-26 |
|
| Muscarinic receptor M3 mediates human gallbladder contraction through voltage-gated Ca2+ channels and Rho kinase. | 2013-02 |
|
| Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators. | 2010-10-01 |
|
| Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM. | 2010-01-15 |
|
| Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. | 2009-06-11 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Apr 02 05:41:32 GMT 2025
by
admin
on
Wed Apr 02 05:41:32 GMT 2025
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| Record UNII |
ZH1ZWF5Q3P
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| Record Status |
Validated (UNII)
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| Record Version |
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DTXSID40655290
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ZH1ZWF5Q3P
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1160247-92-6
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42633508
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VU-0238429
Created by
admin on Wed Apr 02 05:41:32 GMT 2025 , Edited by admin on Wed Apr 02 05:41:32 GMT 2025
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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TARGET -> ACTIVATOR |
selective positive allosteric modulator
ALLOSTERIC ACTIVATOR
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
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