VU-0238429

COC1=CC=C(CN2C(=O)C(=O)C3=CC(OC(F)(F)F)=CC=C23)C=C1

InChIKey=CKLGZXFOLMHCMC-UHFFFAOYSA-N

InChI=1S/C17H12F3NO4/c1-24-11-4-2-10(3-5-11)9-21-14-7-6-12(25-17(18,19)20)8-13(14)15(22)16(21)23/h2-8H,9H2,1H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Muscarinic acetylcholine receptor M5 62 Target ID: Q920H4 Gene ID: 213788.0 Gene Symbol: Chrm5 Target Organism: Mus musculus (Mouse) Sources: https://www.ncbi.nlm.nih.gov/pubmed/19438238	Positive Allosteric Modulator 179		1.16 µM [EC50]

PubMed

Title	Date	PubMed
Muscarinic receptor M3 mediates human gallbladder contraction through voltage-gated Ca2+ channels and Rho kinase.	2013 Feb	23227858
M5 receptor activation produces opposing physiological outcomes in dopamine neurons depending on the receptor's location.	2014 Feb 26	24573284
Simultaneous activation of muscarinic and GABA(B) receptors as a bidirectional target for novel antipsychotics.	2019 Feb 1	30267715
Simultaneous activation of mGlu(2) and muscarinic receptors reverses MK-801-induced cognitive decline in rodents.	2020 Sep 1	31785263

Substance Class	Chemical Created by `admin` on `Sat Dec 16 15:26:02 UTC 2023` Edited by `admin` on `Sat Dec 16 15:26:02 UTC 2023`
Record UNII	ZH1ZWF5Q3P
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

VU-0238429

Code

English

1-((4-METHOXYPHENYL)METHYL)-5-(TRIFLUOROMETHOXY)-1H-INDOLE-2,3-DIONE

Systematic Name

English

1-(4-METHOXY-BENZYL)-5-TRIFLUOROMETHOXY-1H-INDOLE-2,3-DIONE

Systematic Name

English

ML-129

Code

English

1H-INDOLE-2,3-DIONE, 1-((4-METHOXYPHENYL)METHYL)-5-(TRIFLUOROMETHOXY)-

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID40655290