DESMENINOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C5H10O3S
Molecular Weight	150.196
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CSCCC(O)C(O)=O

InChI

InChIKey=ONFOSYPQQXJWGS-UHFFFAOYSA-N

InChI=1S/C5H10O3S/c1-9-3-2-4(6)5(7)8/h4,6H,2-3H2,1H3,(H,7,8)

HIDE SMILES / InChI

Molecular Formula	C5H10O3S
Molecular Weight	150.196
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.novusint.com/Products/alimet | Milne, G.W.A. (2005) Gardner's Commercially Important Chemicals, page 182, retrieved from: https://books.google.ru/books?id=oWdc2qcb3QsC | Advice Concerning the Addition of Certain Pharmaceutical Products and Chemical Intermediates to the Pharmaceutical Appendix to the Harmonized Tariff Schedule of the United States, Inv. 332-476, page C-19, retrieved from: https://books.google.ru/books?id=ZbUM36IWbSIC

Desmeninol is a methionine hydroxyl analog. It is used as a feed additive for livestock, especially poultry to provide an essential amino acid necessary for the nutritional well being of farm raised animals. Desmeninol (ALIMET) has 88% methionine activity and is 100 percent absorbed by the animal. The benefits of ALIMET go beyond it being a methionine source, including: Antioxidant effect in the feed; Maintained performance during heat stress; Energy savings in the feed mill; Increased feed intake.

Approval Year

PubMed

Title	Date	PubMed
Lactobacillus casei and Lactobacillus plantarum initiate catabolism of methionine by transamination.	2001 Jun	11412327
Uptake of DL-2-hydroxy-4-methylthio-butanoic acid (DL-HMB) in the broiler liver in vivo.	2001 Nov	11732679
Rumen degradation and availability of various amounts of liquid methionine hydroxy analog in lactating dairy cows.	2002 Apr	12018438
Effects of zinc and sodium monensin on ruminal degradation of lysine-HCl and liquid 2-hydroxy-4-methylthiobutanoic acid.	2004 Aug	15328281
Estimation of bioavailability of DL-methionine hydroxy analogue relative to DL-methionine in layers with exponential and slope-ratio models.	2004 Sep	15384910
The influence of dietary sodium chloride, arginine:lysine ratio, and methionine source on apparent ileal digestibility of arginine and lysine in acutely heat-stressed broilers.	2005 Feb	15742966
Metal chelates of 2-hydroxy-4-methylthiobutanoic acid in animal feeding. Part 2: Further characterizations, in vitro and in vivo investigations.	2005 Feb	15621297
Estimation of the ideal ratio of true ileal digestible sulfur amino acids:lysine in 8- to 26-kg nursery pigs.	2005 Nov	16230649
Comparative in vitro and in vivo absorption of 2-hydroxy-4(methylthio) butanoic acid and methionine in the broiler chicken.	2005 Sep	16206561
No evidence for different dose responses of commercial methionine sources in broilers.	2006 Dec	17135657
Oligomers are not the limiting factor in the absorption of DL-2-hydroxy-4-(methylthio)butanoic acid in the chicken small intestine.	2006 Jan	16493946
Hepatic metabolism of 2-hydroxy-4-methylthiobutyrate in growing lambs.	2006 Mar	16507703
Conversion of the methionine hydroxy analogue DL-2-hydroxy-(4-methylthio) butanoic acid to sulfur-containing amino acids in the chicken small intestine.	2006 Nov	17032826
Effect of different dietary methionine sources on intestinal microbial populations in broiler chickens.	2007 Nov	17954586
Effect of excess methionine and methionine hydroxy analogue on growth performance and plasma homocysteine of growing Pekin ducks.	2007 Sep	17704389

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:04:49 GMT 2023` Edited by `admin` on `Sat Dec 16 16:04:49 GMT 2023`
Record UNII	Z94465H1Y7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DESMENINOL

Official Name

English

2-HYDROXY-4-(METHYLTHIO)BUTANOIC ACID

Systematic Name

English

DL-2-HYDROXY-4-METHYLTHIO-BUTANOIC ACID

Common Name

English

desmeninol [INN]

Common Name

English

2-HYDROXY-4-(METHYLTHIO)BUTYRIC ACID

Systematic Name

English

METHIONINE HYDROXY ANALOG [MI]

Common Name

English

BUTANOIC ACID, 2-HYDROXY-4-(METHYLTHIO)-

Common Name

English

(±)-2-HYDROXY-4-(METHYLTHIO)BUTYRIC ACID

Systematic Name

English

Desmeninol [WHO-DD]

Common Name

English

BUTYRIC ACID, 2-HYDROXY-4-(METHYLTHIO)-

Common Name

English

2-HYDROXY-4-METHYLTHIO-BUTANOIC ACID, (±)-

Common Name

English

DESMENINOL [HSDB]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C1505