BUTRIPTYLINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C21H27N
Molecular Weight	293.4458
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of BUTRIPTYLINE

Structure Search

SMILES

CC(CC1C2=CC=CC=C2CCC3=CC=CC=C13)CN(C)C

InChI

InChIKey=ALELTFCQZDXAMQ-UHFFFAOYSA-N

InChI=1S/C21H27N/c1-16(15-22(2)3)14-21-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)21/h4-11,16,21H,12-15H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C21H27N
Molecular Weight	293.4458
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1036481

Butriptyline is a tricyclic antidepressant used in patients with depression associated with anxiety. The drug is supposed to be withdrawn from the market as the last publication about its clinical use is dated by 1988.

CNS Activity

Approval Year

Conditions

Conditions

Condition	Modality	Targets	Highest Phase	Product
Depression 235 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1036481	Primary		Approved 8429	EVADYNE Approved Use Unknown

PubMed

PubMed

Title	Date	PubMed
Psychopharmacological evaluation of a new antidepressant: butriptyline.	1969 Dec	5371184

Sample Use Guides

In Vivo Use Guide

The daily dosage is between 75 and 150 mg/day.

Route of Administration: Oral

In Vitro Use Guide

Butriptyline exhibited rather potent inhibition of 3H-dopamine uptake in rat corpus striatum with IC50 value in the range 10(-6)-10(-5) M.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:09:21 GMT 2023` Edited by `admin` on `Fri Dec 15 16:09:21 GMT 2023`
Record UNII	Z22441975X
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

BUTRIPTYLINE

Official Name

English

(±)-10,11-DIHYDRO-N,N,.BETA.-TRIMETHYL-5H-DIBENZO(A,D)CYCLOHEPTENE-5-PROPYLAMINE

Systematic Name

English

5H-DIBENZO(A,D)CYCLOHEPTENE-5-PROPANAMINE, 10,11-DIHYDRO-N,N,.BETA.-TRIMETHYL-, (±)-

Systematic Name

English

BUTRIPTYLINE [MI]

Common Name

English

butriptyline [INN]

Common Name

English

Butriptyline [WHO-DD]

Common Name

English

EVADYNE

Brand Name

English

Classification Tree Code System Code

WHO-VATC

QN06AA15

Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023

NCI_THESAURUS

C265

Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023

WHO-ATC

N06AA15

Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023

Code System Code Type Description

PUBCHEM

21772

Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023

PRIMARY

RXCUI

19895

Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023

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RxNorm

SMS_ID

100000076906

Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023

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DRUG BANK

DB09016

Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023

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EVMPD

SUB13137MIG

Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023

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FDA UNII

Z22441975X

Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023

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CAS

35941-65-2

Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023

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NCI_THESAURUS

C79855

Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023

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DRUG CENTRAL

455

Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023

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MERCK INDEX

m2805

Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023

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Merck Index

INN

2123

Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023

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WIKIPEDIA

BUTRIPTYLINE

Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023

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ChEMBL

CHEMBL2110816

Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023

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EPA CompTox

DTXSID6022715

Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023

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Related Record Type Details


					OE8026NXVX

BUTRIPTYLINE, (S)-

ENANTIOMER -> RACEMATE


					NQI5D806LC

5-HYDROXYTRYPTAMINE RECEPTOR 2A

TARGET -> INHIBITOR


					LIJ2H8658W

BUTRIPTYLINE HYDROCHLORIDE

SALT/SOLVATE -> PARENT


					U3CV8K30PO

BUTRIPTYLINE, (R)-

ENANTIOMER -> RACEMATE

Related Record Type Details


					Z22441975X

ACTIVE MOIETY