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Details

Stereochemistry RACEMIC
Molecular Formula C21H27N
Molecular Weight 293.4458
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BUTRIPTYLINE

SMILES

CC(CC1C2=CC=CC=C2CCC3=CC=CC=C13)CN(C)C

InChI

InChIKey=ALELTFCQZDXAMQ-UHFFFAOYSA-N
InChI=1S/C21H27N/c1-16(15-22(2)3)14-21-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)21/h4-11,16,21H,12-15H2,1-3H3

HIDE SMILES / InChI

Molecular Formula C21H27N
Molecular Weight 293.4458
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Butriptyline is a tricyclic antidepressant used in patients with depression associated with anxiety. The drug is supposed to be withdrawn from the market as the last publication about its clinical use is dated by 1988.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
EVADYNE

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Psychopharmacological evaluation of a new antidepressant: butriptyline.
1969 Dec
Clinical experience with butriptyline (AY-62014) in the treatment of depressions.
1971
Report of butriptyline hydrochloride (Evadyne) in ambulatory patients.
1971
Effect of butriptyline on subjective feelings and sleep.
1977 Apr
Some clinical pharmacological studies with butriptyline, an antidepressive drug.
1977 Feb

Sample Use Guides

The daily dosage is between 75 and 150 mg/day.
Route of Administration: Oral
In Vitro Use Guide
Butriptyline exhibited rather potent inhibition of 3H-dopamine uptake in rat corpus striatum with IC50 value in the range 10(-6)-10(-5) M.
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:09:21 GMT 2023
Edited
by admin
on Fri Dec 15 16:09:21 GMT 2023
Record UNII
Z22441975X
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BUTRIPTYLINE
INN   MI   WHO-DD  
INN  
Official Name English
(±)-10,11-DIHYDRO-N,N,.BETA.-TRIMETHYL-5H-DIBENZO(A,D)CYCLOHEPTENE-5-PROPYLAMINE
Systematic Name English
5H-DIBENZO(A,D)CYCLOHEPTENE-5-PROPANAMINE, 10,11-DIHYDRO-N,N,.BETA.-TRIMETHYL-, (±)-
Systematic Name English
BUTRIPTYLINE [MI]
Common Name English
butriptyline [INN]
Common Name English
Butriptyline [WHO-DD]
Common Name English
EVADYNE
Brand Name English
Classification Tree Code System Code
WHO-VATC QN06AA15
Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023
NCI_THESAURUS C265
Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023
WHO-ATC N06AA15
Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023
Code System Code Type Description
PUBCHEM
21772
Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023
PRIMARY
RXCUI
19895
Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023
PRIMARY RxNorm
SMS_ID
100000076906
Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023
PRIMARY
DRUG BANK
DB09016
Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023
PRIMARY
EVMPD
SUB13137MIG
Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023
PRIMARY
FDA UNII
Z22441975X
Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023
PRIMARY
CAS
35941-65-2
Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023
PRIMARY
NCI_THESAURUS
C79855
Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023
PRIMARY
DRUG CENTRAL
455
Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023
PRIMARY
MERCK INDEX
m2805
Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023
PRIMARY Merck Index
INN
2123
Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023
PRIMARY
WIKIPEDIA
BUTRIPTYLINE
Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023
PRIMARY
ChEMBL
CHEMBL2110816
Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023
PRIMARY
EPA CompTox
DTXSID6022715
Created by admin on Fri Dec 15 16:09:21 GMT 2023 , Edited by admin on Fri Dec 15 16:09:21 GMT 2023
PRIMARY
Related Record Type Details
ENANTIOMER -> RACEMATE
TARGET -> INHIBITOR
SALT/SOLVATE -> PARENT
ENANTIOMER -> RACEMATE
Related Record Type Details
ACTIVE MOIETY