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Details

Stereochemistry RACEMIC
Molecular Formula C21H27N.ClH
Molecular Weight 329.907
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BUTRIPTYLINE HYDROCHLORIDE

SMILES

Cl.CC(CC1C2=CC=CC=C2CCC3=CC=CC=C13)CN(C)C

InChI

InChIKey=MCWAFEJHLHEFOD-UHFFFAOYSA-N
InChI=1S/C21H27N.ClH/c1-16(15-22(2)3)14-21-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)21;/h4-11,16,21H,12-15H2,1-3H3;1H

HIDE SMILES / InChI

Molecular Formula C21H27N
Molecular Weight 293.4458
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Butriptyline is a tricyclic antidepressant used in patients with depression associated with anxiety. The drug is supposed to be withdrawn from the market as the last publication about its clinical use is dated by 1988.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
EVADYNE

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Psychopharmacological evaluation of a new antidepressant: butriptyline.
1969 Dec

Sample Use Guides

The daily dosage is between 75 and 150 mg/day.
Route of Administration: Oral
In Vitro Use Guide
Butriptyline exhibited rather potent inhibition of 3H-dopamine uptake in rat corpus striatum with IC50 value in the range 10(-6)-10(-5) M.
Substance Class Chemical
Created
by admin
on Thu Jul 06 01:00:16 UTC 2023
Edited
by admin
on Thu Jul 06 01:00:16 UTC 2023
Record UNII
LIJ2H8658W
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BUTRIPTYLINE HYDROCHLORIDE
MART.   MI   USAN   WHO-DD  
USAN  
Official Name English
5H-DIBENZO(A,D)CYCLOHEPTENE-5-PROPANAMINE, 10,11-DIHYDRO-N,N,.BETA.-TRIMETHYL-, HYDROCHLORIDE, (±)-
Systematic Name English
BUTRIPTYLINE HYDROCHLORIDE [USAN]
Common Name English
AY-62014
Code English
BUTRIPTYLINE HYDROCHLORIDE [MI]
Common Name English
BUTRIPTYLINE HCL
Common Name English
(±)-10,11-DIHYDRO-N,N,.BETA.-TRIMETHYL-5H-DIBENZO(A,D)CYCLOHEPTENE-5-PROPYLAMINE HYDROCHLORIDE
Systematic Name English
BUTRIPTYLINE HYDROCHLORIDE [MART.]
Common Name English
Butriptyline hydrochloride [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C265
Created by admin on Thu Jul 06 01:00:16 UTC 2023 , Edited by admin on Thu Jul 06 01:00:16 UTC 2023
Code System Code Type Description
MERCK INDEX
M2805
Created by admin on Thu Jul 06 01:00:16 UTC 2023 , Edited by admin on Thu Jul 06 01:00:16 UTC 2023
PRIMARY Merck Index
ECHA (EC/EINECS)
226-983-8
Created by admin on Thu Jul 06 01:00:16 UTC 2023 , Edited by admin on Thu Jul 06 01:00:16 UTC 2023
PRIMARY
ChEMBL
CHEMBL2110816
Created by admin on Thu Jul 06 01:00:16 UTC 2023 , Edited by admin on Thu Jul 06 01:00:16 UTC 2023
PRIMARY
PUBCHEM
21771
Created by admin on Thu Jul 06 01:00:16 UTC 2023 , Edited by admin on Thu Jul 06 01:00:16 UTC 2023
PRIMARY
DRUG BANK
DBSALT001091
Created by admin on Thu Jul 06 01:00:16 UTC 2023 , Edited by admin on Thu Jul 06 01:00:16 UTC 2023
PRIMARY
NCI_THESAURUS
C79856
Created by admin on Thu Jul 06 01:00:16 UTC 2023 , Edited by admin on Thu Jul 06 01:00:16 UTC 2023
PRIMARY
FDA UNII
LIJ2H8658W
Created by admin on Thu Jul 06 01:00:16 UTC 2023 , Edited by admin on Thu Jul 06 01:00:16 UTC 2023
PRIMARY
CAS
5585-73-9
Created by admin on Thu Jul 06 01:00:16 UTC 2023 , Edited by admin on Thu Jul 06 01:00:16 UTC 2023
PRIMARY
SMS_ID
100000084843
Created by admin on Thu Jul 06 01:00:16 UTC 2023 , Edited by admin on Thu Jul 06 01:00:16 UTC 2023
PRIMARY
RXCUI
324004
Created by admin on Thu Jul 06 01:00:16 UTC 2023 , Edited by admin on Thu Jul 06 01:00:16 UTC 2023
PRIMARY RxNorm
EVMPD
SUB00922MIG
Created by admin on Thu Jul 06 01:00:16 UTC 2023 , Edited by admin on Thu Jul 06 01:00:16 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
ENANTIOMER -> RACEMATE
ENANTIOMER -> RACEMATE
Related Record Type Details
ACTIVE MOIETY