BUTRIPTYLINE HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C21H27N.ClH
Molecular Weight	329.907
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC(CC1C2=CC=CC=C2CCC3=CC=CC=C13)CN(C)C

InChI

InChIKey=MCWAFEJHLHEFOD-UHFFFAOYSA-N

InChI=1S/C21H27N.ClH/c1-16(15-22(2)3)14-21-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)21;/h4-11,16,21H,12-15H2,1-3H3;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C21H27N
Molecular Weight	293.4458
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1036481

Butriptyline is a tricyclic antidepressant used in patients with depression associated with anxiety. The drug is supposed to be withdrawn from the market as the last publication about its clinical use is dated by 1988.

CNS Activity

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Depression 235 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1036481	Primary		Approved 8429	EVADYNE Approved Use Unknown

PubMed

Title	Date	PubMed
Psychopharmacological evaluation of a new antidepressant: butriptyline.	1969 Dec	5371184
Clinical experience with butriptyline (AY-62014) in the treatment of depressions.	1971	4948364
Report of butriptyline hydrochloride (Evadyne) in ambulatory patients.	1971	4948365
Effect of butriptyline on subjective feelings and sleep.	1977 Apr	193546
Some clinical pharmacological studies with butriptyline, an antidepressive drug.	1977 Feb	576584

Sample Use Guides

In Vivo Use Guide

The daily dosage is between 75 and 150 mg/day.

Route of Administration: Oral

In Vitro Use Guide

Butriptyline exhibited rather potent inhibition of 3H-dopamine uptake in rat corpus striatum with IC50 value in the range 10(-6)-10(-5) M.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:42:14 GMT 2023` Edited by `admin` on `Fri Dec 15 17:42:14 GMT 2023`
Record UNII	LIJ2H8658W
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BUTRIPTYLINE HYDROCHLORIDE

Official Name

English

5H-DIBENZO(A,D)CYCLOHEPTENE-5-PROPANAMINE, 10,11-DIHYDRO-N,N,.BETA.-TRIMETHYL-, HYDROCHLORIDE, (±)-

Systematic Name

English

BUTRIPTYLINE HYDROCHLORIDE [USAN]

Common Name

English

AY-62014

Code

English

BUTRIPTYLINE HYDROCHLORIDE [MI]

Common Name

English

BUTRIPTYLINE HCL

Common Name

English

(±)-10,11-DIHYDRO-N,N,.BETA.-TRIMETHYL-5H-DIBENZO(A,D)CYCLOHEPTENE-5-PROPYLAMINE HYDROCHLORIDE

Systematic Name

English

BUTRIPTYLINE HYDROCHLORIDE [MART.]

Common Name

English

Butriptyline hydrochloride [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C265