Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C21H27NO2 |
| Molecular Weight | 325.4446 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC1=C(OC[C@@H](O)CN[C@H]2CCCC3=C2C=CC=C3)C=CC=C1
InChI
InChIKey=VFDHMSXXELYMRW-ICSRJNTNSA-N
InChI=1S/C21H27NO2/c1-2-16-8-4-6-13-21(16)24-15-18(23)14-22-20-12-7-10-17-9-3-5-11-19(17)20/h3-6,8-9,11,13,18,20,22-23H,2,7,10,12,14-15H2,1H3/t18-,20-/m0/s1
| Molecular Formula | C21H27NO2 |
| Molecular Weight | 325.4446 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: description was created based on several sources, including
https://www.google.com/patents/WO2002009760A3 | https://www.ncbi.nlm.nih.gov/pubmed/8569714 | https://www.ncbi.nlm.nih.gov/pubmed/24175568
Curator's Comment: description was created based on several sources, including
https://www.google.com/patents/WO2002009760A3 | https://www.ncbi.nlm.nih.gov/pubmed/8569714 | https://www.ncbi.nlm.nih.gov/pubmed/24175568
SR 59230A is orally active, selective antagonist of the beta-3 adrenergic receptor, SR 59230A has high affinity for the β3 adrenoceptors occurring in human gut that affect the function of human colonic circular smooth muscle.
Originator
Approval Year
Sample Use Guides
The Goto-Kakizaki (GK) rat aged 3–4 months were treated with SR 59230A. Osmotic pumps (2 ml, 5.0 l/h, 2 weeks duration; Alzet pump, Cupertino, CA, USA) were filled with either SR59230A (0.6 mg/kg * day; Bachem, St. Helen’s Merseyside, UK) or 0.9% NaCl according to manufacturer’s instruction and implanted subcutaneously between the shoulder blades of the rats.
Route of Administration:
Other
Isolated rat adipocytes were washed 3 times and incubated in 0.5 ml KRBHA at 37°C (2–5•104 cells) with gentle shaking. SR 59230A at suitable dilutions were added in a 5 μl volume to the cell suspension just before beginning the assay. After 90 min incubation, the reaction was stopped in ice and aliquots taken for enzymatic determination of glycerol, used as the index of lipolysis
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:15:02 GMT 2023
by
admin
on
Sat Dec 16 08:15:02 GMT 2023
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| Record UNII |
YZ574930OD
|
| Record Status |
Validated (UNII)
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| Record Version |
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DTXSID6043884
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174689-38-4
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| Related Record | Type | Details | ||
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TARGET -> INHIBITOR |
IC50
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SALT/SOLVATE -> PARENT |
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