| Stereochemistry | ABSOLUTE |
| Molecular Formula | C21H27NO2.C2H2O4 |
| Molecular Weight | 415.4795 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C(O)=O.CCC1=C(OC[C@@H](O)CN[C@H]2CCCC3=CC=CC=C23)C=CC=C1
InChI
InChIKey=XTBQNQMNFXNGLR-MKSBGGEFSA-N
InChI=1S/C21H27NO2.C2H2O4/c1-2-16-8-4-6-13-21(16)24-15-18(23)14-22-20-12-7-10-17-9-3-5-11-19(17)20;3-1(4)2(5)6/h3-6,8-9,11,13,18,20,22-23H,2,7,10,12,14-15H2,1H3;(H,3,4)(H,5,6)/t18-,20-;/m0./s1
| Molecular Formula | C21H27NO2 |
| Molecular Weight | 325.4446 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | C2H2O4 |
| Molecular Weight | 90.0349 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
| 49.0 nM [Ki] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
PubMed
Patents
Sample Use Guides
The Goto-Kakizaki (GK) rat aged 3–4 months were treated with SR 59230A. Osmotic pumps (2 ml, 5.0 l/h, 2 weeks duration; Alzet pump, Cupertino, CA, USA) were filled with either SR59230A (0.6 mg/kg * day; Bachem, St. Helen’s Merseyside, UK) or 0.9% NaCl according to manufacturer’s instruction and implanted subcutaneously between the shoulder blades of the rats.
Route of Administration:
Other
Isolated rat adipocytes were washed 3 times and incubated in 0.5 ml KRBHA at 37°C (2–5•104 cells) with gentle shaking. SR 59230A at suitable dilutions were added in a 5 μl volume to the cell suspension just before beginning the assay. After 90 min incubation, the reaction was stopped in ice and aliquots taken for enzymatic determination of glycerol, used as the index of lipolysis
