REMEGLURANT

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C17H15BrN4O
Molecular Weight	371.231
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@H]1N(CCC2=C1C=CC=C2)C(=O)C3=NN4C=C(Br)C=NC4=C3

InChI

InChIKey=TUYZYSNXXSTKQX-LLVKDONJSA-N

InChI=1S/C17H15BrN4O/c1-11-14-5-3-2-4-12(14)6-7-21(11)17(23)15-8-16-19-9-13(18)10-22(16)20-15/h2-5,8-11H,6-7H2,1H3/t11-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C17H15BrN4O
Molecular Weight	371.231
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.medkoo.com/products/7852 | https://adisinsight.springer.com/drugs/800045269

Remeglurant is a selective antagonist of subtype 5 metabotropic glutamate receptors (mGluR5). mGluR5 antagonists have a modulatory role in the control of glutamatergic neurotransmission. This drug was developed for treatment in drug-induced dyskinesia (an involuntary movement disorder). A phase 1 trial was conducted but no further development has been reported since 2016.

Originator

Approval Year

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:42:42 GMT 2023` Edited by `admin` on `Sat Dec 16 10:42:42 GMT 2023`
Record UNII	Y7H8880HMD
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

REMEGLURANT

Official Name

English

METHANONE, (6-BROMOPYRAZOLO(1,5-A)PYRIMIDIN-2-YL)((1R)-3,4-DIHYDRO-1-METHYL-2(1H)-ISOQUINOLINYL)-

Systematic Name

English

remeglurant [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C38149