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Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Wed Apr 02 02:41:49 GMT 2025
Edited
by admin
on Wed Apr 02 02:41:49 GMT 2025
Protein Sub Type
Sequence Type COMPLETE
Record UNII
782U83M4P1
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
METABOTROPIC GLUTAMATE RECEPTOR 5
Common Name English
GPRC1E
Preferred Name English
MGLUR5
Common Name English
GRM5
Common Name English
Code System Code Type Description
FDA UNII
782U83M4P1
Created by admin on Wed Apr 02 02:41:49 GMT 2025 , Edited by admin on Wed Apr 02 02:41:49 GMT 2025
PRIMARY
UNIPROT
P41594
Created by admin on Wed Apr 02 02:41:49 GMT 2025 , Edited by admin on Wed Apr 02 02:41:49 GMT 2025
PRIMARY
From To
1_37 1_79
1_221 1_510
1_256 1_258
1_345 1_361
1_399 1_406
1_491 1_511
1_495 1_514
1_517 1_529
1_532 1_545
1_624 1_713
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_68
N 1_190
N 1_358
N 1_362
N 1_425
N 1_714
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Structure of BASIMGLURANT
INHIBITOR -> TARGET
NEGATIVE ALLOSTERIC MODULATOR
Structure of DIPRAGLURANT
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Structure of RASEGLURANT
INHIBITOR -> TARGET
Raseglurant (ADX10059) has a selective, noncompetitive inhibitory activity mediated by mGlu5 receptor modulation via binding to an allosteric site (IC50 of 17.1 nM on human mGlu receptors)
IC50
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INHIBITOR -> TARGET
Structure of AZD-2066
INHIBITOR -> TARGET
Structure of 2-METHYL-6-(PHENYLETHYNYL)PYRIDINE
INHIBITOR -> TARGET
Binding Assay
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INHIBITOR -> TARGET
Structure of Acamprosate
AGONIST -> TARGET

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_841] [1_998] [1_1000] DEXFOSFOSERINE VI4F0K069V
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
Molecular Formula CHEMICAL
NIH
NCATS
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