U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Jun 26 18:23:31 UTC 2021
Edited
by admin
on Sat Jun 26 18:23:31 UTC 2021
Protein Sub Type
Sequence Type COMPLETE
Record UNII
782U83M4P1
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
METABOTROPIC GLUTAMATE RECEPTOR 5
Common Name English
GPRC1E
Common Name English
MGLUR5
Common Name English
GRM5
Common Name English
Code System Code Type Description
FDA UNII
782U83M4P1
Created by admin on Sat Jun 26 18:23:32 UTC 2021 , Edited by admin on Sat Jun 26 18:23:32 UTC 2021
PRIMARY
UNIPROT
P41594
Created by admin on Sat Jun 26 18:23:32 UTC 2021 , Edited by admin on Sat Jun 26 18:23:32 UTC 2021
PRIMARY
From To
1_37 1_79
1_221 1_510
1_256 1_258
1_345 1_361
1_399 1_406
1_491 1_511
1_495 1_514
1_517 1_529
1_532 1_545
1_624 1_713
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_68
N 1_190
N 1_358
N 1_362
N 1_425
N 1_714
Related Record Type Details
INHIBITOR -> TARGET
MODULATOR->TARGET
INHIBITOR -> TARGET
ANTAGONIST
IC50
ANTAGONIST->TARGET
INHIBITOR -> TARGET
ANTAGONIST
INHIBITOR -> TARGET
NEGATIVE ALLOSTERIC MODULATOR
MODULATOR->TARGET
INHIBITOR -> TARGET
Raseglurant (ADX10059) has a selective, noncompetitive inhibitory activity mediated by mGlu5 receptor modulation via binding to an allosteric site (IC50 of 17.1 nM on human mGlu receptors)
IC50
INHIBITOR -> TARGET
AGONIST -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL