Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Wed Apr 02 02:41:49 GMT 2025
by
admin
on
Wed Apr 02 02:41:49 GMT 2025
|
| Protein Sub Type | |
| Sequence Type | COMPLETE |
| Record UNII |
782U83M4P1
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Preferred Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
782U83M4P1
Created by
admin on Wed Apr 02 02:41:49 GMT 2025 , Edited by admin on Wed Apr 02 02:41:49 GMT 2025
|
PRIMARY | |||
|
P41594
Created by
admin on Wed Apr 02 02:41:49 GMT 2025 , Edited by admin on Wed Apr 02 02:41:49 GMT 2025
|
PRIMARY |
| From | To |
|---|---|
| 1_37 | 1_79 |
| 1_221 | 1_510 |
| 1_256 | 1_258 |
| 1_345 | 1_361 |
| 1_399 | 1_406 |
| 1_491 | 1_511 |
| 1_495 | 1_514 |
| 1_517 | 1_529 |
| 1_532 | 1_545 |
| 1_624 | 1_713 |
| Glycosylation Type | HUMAN |
| Glycosylation Link Type | Site |
|---|---|
| N | 1_68 |
| N | 1_190 |
| N | 1_358 |
| N | 1_362 |
| N | 1_425 |
| N | 1_714 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
RADIOLIGAND->TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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MODULATOR->TARGET |
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NEGATIVE ALLOSTERIC MODULATOR->TARGET |
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NEGATIVE ALLOSTERIC MODULATOR->TARGET |
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INHIBITOR -> TARGET |
ANTAGONIST
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NEGATIVE ALLOSTERIC MODULATOR->TARGET |
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ANTAGONIST->TARGET |
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INHIBITOR -> TARGET |
NEGATIVE ALLOSTERIC MODULATOR
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MODULATOR->TARGET |
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INHIBITOR -> TARGET |
Raseglurant (ADX10059) has a selective, noncompetitive inhibitory activity mediated by mGlu5 receptor modulation via binding to an allosteric site (IC50 of 17.1 nM on human mGlu receptors)
IC50
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
Binding Assay
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INHIBITOR -> TARGET |
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AGONIST -> TARGET |
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Structural Modifications
| Modification Type | Location Site | Location Type | Residue Modified | Extent | Fragment Name | Fragment Approval |
|---|---|---|---|---|---|---|
| AMINO ACID SUBSTITUTION | [1_841] [1_998] [1_1000] | DEXFOSFOSERINE | VI4F0K069V |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT | CHEMICAL |
|
||||
| Molecular Formula | CHEMICAL |
|