U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
139594
Substance Class Protein
Created
by admin
on Sat Dec 16 14:59:47 GMT 2023
Edited
by admin
on Sat Dec 16 14:59:47 GMT 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
782U83M4P1
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
METABOTROPIC GLUTAMATE RECEPTOR 5
Common Name English
GPRC1E
Common Name English
MGLUR5
Common Name English
GRM5
Common Name English
Code System Code Type Description
FDA UNII
782U83M4P1
Created by admin on Sat Dec 16 14:59:48 GMT 2023 , Edited by admin on Sat Dec 16 14:59:48 GMT 2023
PRIMARY
UNIPROT
P41594
Created by admin on Sat Dec 16 14:59:48 GMT 2023 , Edited by admin on Sat Dec 16 14:59:48 GMT 2023
PRIMARY
From To
1_37 1_79
1_221 1_510
1_256 1_258
1_345 1_361
1_399 1_406
1_491 1_511
1_495 1_514
1_517 1_529
1_532 1_545
1_624 1_713
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_68
N 1_190
N 1_358
N 1_362
N 1_425
N 1_714
Related Record Type Details
ABP-688 C-11
RADIOLIGAND->TARGET
Structure of RGH-618
INHIBITOR -> TARGET
Structure of BMS-984923
MODULATOR->TARGET
Structure of GRN-529
NEGATIVE ALLOSTERIC MODULATOR->TARGET
Structure of DMEOB
NEGATIVE ALLOSTERIC MODULATOR->TARGET
Structure of SIB-1893
INHIBITOR -> TARGET
ANTAGONIST
Structure of MFZ10-7
NEGATIVE ALLOSTERIC MODULATOR->TARGET
Structure of AZD-2066
INHIBITOR -> TARGET
ANTAGONIST
Structure of MAVOGLURANT
ANTAGONIST->TARGET
Structure of BASIMGLURANT
INHIBITOR -> TARGET
NEGATIVE ALLOSTERIC MODULATOR
Structure of DIPRAGLURANT
MODULATOR->TARGET
Structure of RASEGLURANT
INHIBITOR -> TARGET
Raseglurant (ADX10059) has a selective, noncompetitive inhibitory activity mediated by mGlu5 receptor modulation via binding to an allosteric site (IC50 of 17.1 nM on human mGlu receptors)
IC50
Structure of AZD-9272
INHIBITOR -> TARGET
ANTAGONIST
IC50
Structure of REMEGLURANT
INHIBITOR -> TARGET
Structure of 2-METHYL-6-(PHENYLETHYNYL)PYRIDINE
INHIBITOR -> TARGET
Binding Assay
Structure of ACAMPROSATE
INHIBITOR -> TARGET
Structure of ACAMPROSATE
AGONIST -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
Molecular Formula CHEMICAL
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966