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Details

Stereochemistry ACHIRAL
Molecular Formula 2CHO2.Ni
Molecular Weight 148.7283
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NICKEL FORMATE

SMILES

C(=O)[O-].C(=O)[O-].[Ni+2]

InChI

InChIKey=HZPNKQREYVVATQ-UHFFFAOYSA-L
InChI=1S/2CH2O2.Ni/c2*2-1-3;/h2*1H,(H,2,3);/q;;+2/p-2

HIDE SMILES / InChI

Molecular Formula CHO2
Molecular Weight 45.0175
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Ni
Molecular Weight 58.6934
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Nickel is a group VIII transition metal. It is used with other metals to form alloys to make such items as coins, jewelry, valves, heat exchangers, and stainless steel. Nickel compounds are also used to color ceramics, in batteries, and as catalysts. Although it can exist in several different oxidation states, the only important oxidation state under environmental conditions is Ni2+. It has been suggested that nickel may be essential in humans, at levels of less than 0.1 mg Ni/day (<0.001 mg Ni/kg/day for a 70 kg adult), although no nickel requirement or allowance has been set. It is present in most dietary items, and food is considered to be a major source of exposure to nickel for the general population. Systemic reactions, such as generalized eczematous reactions or dyshidrotic hand eczema, can occur due to dietary ingestion of nickel.

Originator

Curator's Comment:: Nickel was discovered by Axel Fredrik Cronstedt at 1751 in Sweden.

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
ECZEMOL

Approved Use

Eczemol® is indicated for the treatment of moderate to severe eczema and atopic dermatitis. It has been found to work well with a variety of combination therapies.
PubMed

PubMed

TitleDatePubMed
NAS-benzidine reaction of blood cells-new simple peroxidase staining method using nickel-ammonium sulfate.
1951 Aug
THE EFFECT OF PHYSICAL FORM OF IMPLANT ON NICKEL SULPHIDE TUMOURIGENESIS IN THE RAT.
1963
EFFECTS OF METHANDROSTENOLONE ON MUSCLE CARCINOGENESIS INDUCED IN RATS BY NICKEL SULPHIDE.
1963 Dec
Nickel concentration of blood and urine after oral administration.
1981 Mar-Apr
Carcinogenicity of nickel(II)hydroxides and nickel(II)sulfate in Wistar rats and its relation to the in vitro dissolution rates.
1983
Nickel oxide: potential carcinogenicity--a review and further evidence.
1984
Pulmonary deposition and clearance of a nickel oxide aerosol by inhalation.
1985 Feb
Carcinogenesis bioassays of nickel oxides and nickel-copper oxides by intramuscular administration to Fischer-344 rats.
1990 Oct
Molecular mechanisms of nickel carcinogenesis.
2002 Feb 28
Molecular biology of nickel carcinogenesis: identification of differentially expressed genes in morphologically transformed C3H10T1/2 Cl 8 mouse embryo fibroblast cell lines induced by specific insoluble nickel compounds.
2004 Jan
Highly selective biaryl cross-coupling reactions between aryl halides and aryl Grignard reagents: a new catalyst combination of N-heterocyclic carbenes and iron, cobalt, and nickel fluorides.
2009 Aug 26
Exposure to nickel, chromium, or cadmium causes distinct changes in the gene expression patterns of a rat liver derived cell line.
2011
An in vitro test to screen skin sensitizers using a stable THP-1-derived IL-8 reporter cell line, THP-G8.
2011 Dec
Pituitary adenylate cyclase-activating peptide (PACAP) recruits low voltage-activated T-type calcium influx under acute sympathetic stimulation in mouse adrenal chromaffin cells.
2011 Dec 9
Activation of Akt/GSK3β and Akt/Bcl-2 signaling pathways in nickel-transformed BEAS-2B cells.
2011 Nov
Nickel(II) induced JNK activation-regulated mitochondria-dependent apoptotic pathway leading to cultured rat pancreatic β-cell death.
2011 Nov 18
Ascorbate antagonizes nickel ion to regulate JMJD1A expression in kidney cancer cells.
2012 Apr
Co-exposure to nickel and cobalt chloride enhances cytotoxicity and oxidative stress in human lung epithelial cells.
2012 Feb 1
Does mechanism matter? Unrelated neurotoxicants converge on cell cycle and apoptosis during neurodifferentiation.
2012 Jul
Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation.
2012 Jul 20
Nickel ion inhibits nuclear factor-kappa B activity in human oral squamous cell carcinoma.
2013
GADD45α induction by nickel negatively regulates JNKs/p38 activation via promoting PP2Cα expression.
2013
L-tyrosinatonickel(II) complex: synthesis and structural, spectroscopic, magnetic, and biological properties of 2{[Ni(L-Tyr)2(bpy)]}·3H2O·CH3OH.
2013 Apr 15
Crucial role of Toll-like receptors in the zinc/nickel-induced inflammatory response in vascular endothelial cells.
2013 Dec 15
Differentiation of skin sensitizers from irritant chemicals by interleukin-1α and macrophage inflammatory protein-2 in murine keratinocytes.
2013 Jan 10
Transition metal sensing by Toll-like receptor-4: next to nickel, cobalt and palladium are potent human dendritic cell stimulators.
2013 Jun
p53 activation by Ni(II) is a HIF-1α independent response causing caspases 9/3-mediated apoptosis in human lung cells.
2013 Jun 15
Differential gene expression profile of the calanoid copepod, Pseudodiaptomus annandalei, in response to nickel exposure.
2013 Mar
Effect of Ni(II) on inflammatory gene expression in THP1 monocytic cells.
2013 Mar
Dietary nickel chloride restrains the development of small intestine in broilers.
2013 Nov
Anti-apoptotic proteins and catalase-dependent apoptosis resistance in nickel chloride-transformed human lung epithelial cells.
2013 Sep
Disturbance of aerobic metabolism accompanies neurobehavioral changes induced by nickel in mice.
2013 Sep
Cobalt and nickel stabilize stem cell transcription factor OCT4 through modulating its sumoylation and ubiquitination.
2014
Nickel-induced cell death and survival pathways in cultured renal proximal tubule cells: roles of reactive oxygen species, ceramide and ABCB1.
2014 Apr
Nickel induces interleukin-1β secretion via the NLRP3-ASC-caspase-1 pathway.
2014 Apr
NiCl2-down-regulated antioxidant enzyme mRNA expression causes oxidative damage in the broiler(')s kidney.
2014 Dec
MiRNA-210 modulates a nickel-induced cellular energy metabolism shift by repressing the iron-sulfur cluster assembly proteins ISCU1/2 in Neuro-2a cells.
2014 Feb 27
Dietary nickel chloride induces oxidative stress, apoptosis and alters Bax/Bcl-2 and caspase-3 mRNA expression in the cecal tonsil of broilers.
2014 Jan
Genotoxic changes to rodent cells exposed in vitro to tungsten, nickel, cobalt and iron.
2014 Mar 10
Whole adult organism transcriptional profiling of acute metal exposures in male zebrafish.
2014 Mar 10
A critical role for thymic stromal lymphopoietin in nickel-induced allergy in mice.
2014 May 1
Detoxification of rats subjected to nickel chloride by a biomaterial-based carbonated orthophosphate.
2014 Sep
The effect of divalent metal cations on zinc uptake by mouse Zrt/Irt-like protein 1 (ZIP1).
2014 Sep 15
Novel Flower-like Nickel Sulfide as an Efficient Electrocatalyst for Non-aqueous Lithium-Air Batteries.
2015 Dec 14
A not cytotoxic nickel concentration alters the expression of neuronal differentiation markers in NT2 cells.
2015 Mar
Innate stimulatory capacity of high molecular weight transition metals Au (gold) and Hg (mercury).
2015 Mar
Chemical allergens stimulate human epidermal keratinocytes to produce lymphangiogenic vascular endothelial growth factor.
2015 Mar 1
Differential Toxicities of Nickel Salts to the Nematode Caenorhabditis elegans.
2016 Aug
Involvement of L-type Ca²⁺ channel and toll-like receptor-4 in nickel-induced interleukin-8 gene expression.
2016 Jan
The regulatory role of nickel on H3K27 demethylase JMJD3 in kidney cancer cells.
2016 Jul
Patents

Sample Use Guides

Nematodes were exposed to seven Ni salts [Ni sulfate hexahydrate (NiSO4·6H2O), Ni chloride hexahydrate (NiCl2·6H2O), Ni acetate tetrahydrate (Ni(OCOCH3)2·4H2O), Ni nitrate hexahydrate (N2NiO6·6H2O), anhydrous Ni iodide (NiI2), Ni sulfamate hydrate (Ni(SO3NH2)2·H2O), and Ni fluoride tetrahydrate (NiF2·4H2O)] in an aquatic medium for 24 h, and lethality curves were generated and analyzed. Ni fluoride, Ni iodide, and Ni chloride were most toxic to C. elegans, followed by Ni nitrate, Ni sulfamate, Ni acetate, and Ni sulfate. The LC50 values of the halogen-containing salts were statistically different from the corresponding value of the least toxic salt, Ni sulfate.
Substance Class Chemical
Created
by admin
on Sat Jun 26 11:25:51 UTC 2021
Edited
by admin
on Sat Jun 26 11:25:51 UTC 2021
Record UNII
Y4YT27N8QN
Record Status Validated (UNII)
Record Version
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Name Type Language
NICKEL FORMATE
HSDB   MI  
Systematic Name English
FORMIC ACID, NICKEL SALT
Common Name English
FORMIC ACID NICKEL(2+) SALT (2:1)
Systematic Name English
NICKEL FORMATE [MI]
Common Name English
NICKEL(II) FORMATE
Systematic Name English
NICKEL FORMATE [HSDB]
Common Name English
NICKEL DIFORMATE
Systematic Name English
NICKELOUS FORMATE
Common Name English
FORMIC ACID, NICKEL(2+) SALT
Common Name English
Code System Code Type Description
CAS
3349-06-2
Created by admin on Sat Jun 26 11:25:51 UTC 2021 , Edited by admin on Sat Jun 26 11:25:51 UTC 2021
PRIMARY
CAS
15843-02-4
Created by admin on Sat Jun 26 11:25:51 UTC 2021 , Edited by admin on Sat Jun 26 11:25:51 UTC 2021
NON-SPECIFIC STOICHIOMETRY
MERCK INDEX
M7864
Created by admin on Sat Jun 26 11:25:51 UTC 2021 , Edited by admin on Sat Jun 26 11:25:51 UTC 2021
PRIMARY Merck Index
HSDB
15843-02-4
Created by admin on Sat Jun 26 11:25:51 UTC 2021 , Edited by admin on Sat Jun 26 11:25:51 UTC 2021
PRIMARY
PUBCHEM
27506
Created by admin on Sat Jun 26 11:25:51 UTC 2021 , Edited by admin on Sat Jun 26 11:25:51 UTC 2021
PRIMARY
ECHA (EC/EINECS)
239-946-6
Created by admin on Sat Jun 26 11:25:51 UTC 2021 , Edited by admin on Sat Jun 26 11:25:51 UTC 2021
ALTERNATIVE
FDA UNII
Y4YT27N8QN
Created by admin on Sat Jun 26 11:25:51 UTC 2021 , Edited by admin on Sat Jun 26 11:25:51 UTC 2021
PRIMARY
ECHA (EC/EINECS)
222-101-0
Created by admin on Sat Jun 26 11:25:51 UTC 2021 , Edited by admin on Sat Jun 26 11:25:51 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY