HYDROCORTAMATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C27H41NO6
Molecular Weight	475.6175
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN(CC)CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12C

InChI

InChIKey=FWFVLWGEFDIZMJ-FOMYWIRZSA-N

InChI=1S/C27H41NO6/c1-5-28(6-2)15-23(32)34-16-22(31)27(33)12-10-20-19-8-7-17-13-18(29)9-11-25(17,3)24(19)21(30)14-26(20,27)4/h13,19-21,24,30,33H,5-12,14-16H2,1-4H3/t19-,20-,21-,24+,25-,26-,27-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C27H41NO6
Molecular Weight	475.6175
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	7 / 7
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5881687

Hydrocortamate is a synthetic glucocorticoid possessing anti-inflammatory properties and acting as a glucocorticoid receptor agonist. Hydrocortamate was used under the brand name Magnacor to treat inflammation due to corticosteroid-responsive dermatoses btut that usage has been discontinued.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Glucocorticoid receptor 173 Target ID: CHEMBL2034	Agonist 2752

Conditions

Condition	Modality	Targets	Highest Phase	Product
Dermatoses 23 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13620553	Palliative		Approved 8583	MAGNACORT Approved Use Unknown

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
substrate 1946

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer

Drug as victim

Target	Modality	Activity	Metabolite	Clinical evidence
CYP3A4 1946	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/20637097/ Page: -	yes

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:50851	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:50851
ZINC	ZINC000004213506	http://zinc15.docking.org/substances/ZINC000004213506

PubMed

Title	Date	PubMed
[On the topical use of a new pharmacological association of enzymes, neomycin and hydrocortamate. Clinical contribution].	1965-11	5881687
Hydrocortamate (magnacort) and neomycin-hydrocortamate (neo-magnacort) ointment in dermatology.	1959-01	13620553

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Irrigation

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:29:05 GMT 2025` Edited by `admin` on `Mon Mar 31 18:29:05 GMT 2025`
Record UNII	Y3N00BK5WK
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

11.BETA.,17.ALPHA.,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE 21-DIETHYLAMINOACETATE

Preferred Name

English

HYDROCORTAMATE

Official Name

English

Hydrocortamate [WHO-DD]

Common Name

English

HYDROCORTAMATE [MI]

Common Name

English

hydrocortamate [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C521