HYDROCORTAMATE HYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C27H41NO6.ClH
Molecular Weight	512.078
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of HYDROCORTAMATE HYDROCHLORIDE

Structure Search

SMILES

Cl.[H][C@@]12CC[C@](O)(C(=O)COC(=O)CN(CC)CC)[C@@]1(C)C[C@H](O)[C@@]3([H])[C@@]2([H])CCC4=CC(=O)CC[C@]34C

InChI

InChIKey=AKQNAIYKSALPKV-OYHXESGYSA-N

InChI=1S/C27H41NO6.ClH/c1-5-28(6-2)15-23(32)34-16-22(31)27(33)12-10-20-19-8-7-17-13-18(29)9-11-25(17,3)24(19)21(30)14-26(20,27)4;/h13,19-21,24,30,33H,5-12,14-16H2,1-4H3;1H/t19-,20-,21-,24+,25-,26-,27-;/m0./s1

HIDE SMILES / InChI

Molecular Formula	C27H41NO6
Molecular Weight	475.6175
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	7 / 7
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5881687

Hydrocortamate is a synthetic glucocorticoid possessing anti-inflammatory properties and acting as a glucocorticoid receptor agonist. Hydrocortamate was used under the brand name Magnacor to treat inflammation due to corticosteroid-responsive dermatoses btut that usage has been discontinued.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Glucocorticoid receptor 172 Target ID: CHEMBL2034	Agonist 2678

Conditions

Condition	Modality	Targets	Highest Phase	Product
Dermatoses 23 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13620553	Palliative		Approved 8429	MAGNACORT Approved Use Unknown

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
substrate 1737

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer

Drug as victim

Target	Modality	Activity	Metabolite	Clinical evidence
CYP3A4 1737	substrate 3367 Sources: https://pubmed.ncbi.nlm.nih.gov/20637097/ Page: -	yes

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:50851	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:50851
ZINC	ZINC000004213506	http://zinc15.docking.org/substances/ZINC000004213506

PubMed

Title	Date	PubMed
Hydrocortamate (magnacort) and neomycin-hydrocortamate (neo-magnacort) ointment in dermatology.	1959 Jan	13620553
[On the topical use of a new pharmacological association of enzymes, neomycin and hydrocortamate. Clinical contribution].	1965 Nov	5881687

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Irrigation

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 14:59:39 GMT 2023` Edited by `admin` on `Fri Dec 15 14:59:39 GMT 2023`
Record UNII	9QM8U7R83W
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HYDROCORTAMATE HYDROCHLORIDE

Common Name

English

HYDROCORTAMATE HCL

Common Name

English

HYDROCORTAMATE HYDROCHLORIDE [MART.]

Common Name

English

NSC-12884

Code

English

Hydrocortamate hydrochloride [WHO-DD]

Common Name

English

MAGNACORT

Brand Name

English

HYDROCORTAMATE HYDROCHLORIDE [MI]

Common Name

English

HYDROCORTAMATE HYDROCHLORIDE [ORANGE BOOK]

Common Name

English

11.BETA.,17.ALPHA.,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE 21-DIETHYLAMINOACETATE HYDROCHLORIDE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C521