CICLAZINDOL

Details

Stereochemistry	UNKNOWN
Molecular Formula	C17H15ClN2O
Molecular Weight	298.767
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC1(C2=NCCCN2C3=C1C=CC=C3)C4=CC=CC(Cl)=C4

InChI

InChIKey=VKQDZNZTPGLGFD-UHFFFAOYSA-N

InChI=1S/C17H15ClN2O/c18-13-6-3-5-12(11-13)17(21)14-7-1-2-8-15(14)20-10-4-9-19-16(17)20/h1-3,5-8,11,21H,4,9-10H2

HIDE SMILES / InChI

Molecular Formula	C17H15ClN2O
Molecular Weight	298.767
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10864893 | https://www.ncbi.nlm.nih.gov/pubmed/8609901 | https://www.ncbi.nlm.nih.gov/pubmed/9723971

Ciclazindol is an indole derivative and monoamine uptake inhibitor patented by pharmaceutical company John Wyeth and Brother Ltd. as an antidepressant. Besides that, Ciclazindol is effective anorectic agent, inducing weight loss in rats and man. Ciclazindol was shown to inhibit ATP-sensitive K+ (K(ATP)) channel currents and stimulate insulin secretion from CRI-G1 insulin-secreting cells. The inhibition of KATP channel currents by ciclazindol is unaffected by the removal of intracellular Mg2+ ions and after trypsinization of the cytoplasmic surface of excised patches, treatments known to abolish sulphonylurea sensitivity.

Originator

Approval Year

PubMed

Title	Date	PubMed
The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1.	2004 Aug 24	15329154

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:09:17 UTC 2023` Edited by `admin` on `Fri Dec 15 16:09:17 UTC 2023`
Record UNII	Y3I9520J7P
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CICLAZINDOL

Official Name

English

WY-23409

Code

English

CICLAZINDOL [USAN]

Common Name

English

PYRIMIDO(1,2-A)INDOL-10-OL, 10-(3-CHLOROPHENYL)-2,3,4,10-TETRAHYDRO-

Systematic Name

English

10-(M-CHLOROPHENYL)-2,3,4,10-TETRAHYDROPYRIMIDO(1,2-A)INDOL-10-OL

Systematic Name

English

ciclazindol [INN]

Common Name

English

WY-23,409

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C265