MATAIRESINOL

COC1=C(O)C=CC(C[C@H]2COC(=O)[C@@H]2CC3=CC(OC)=C(O)C=C3)=C1

InChIKey=MATGKVZWFZHCLI-LSDHHAIUSA-N

InChI=1S/C20H22O6/c1-24-18-9-12(3-5-16(18)21)7-14-11-26-20(23)15(14)8-13-4-6-17(22)19(10-13)25-2/h3-6,9-10,14-15,21-22H,7-8,11H2,1-2H3/t14-,15+/m0/s1

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Targets

Primary Target	Pharmacology	Potency
inflammatory response 47 Target ID: GO:0006954 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28512713	Inhibitor 8504
reactive oxygen species metabolic process 68 Target ID: GO:0072593 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22483751	Modulator 846
Casein kinase I, rat 1 Target ID: Casein kinase I, rat Sources: https://www.ncbi.nlm.nih.gov/pubmed/12612451	Inhibitor 8504	10.0 µM [IC50]
nitric oxide biosynthetic process 17 Target ID: GO:0006809 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27774796	Inhibitor 8504	11.5 µM [IC50]
IL-6/STAT3 pathway 1 Target ID: IL-6/STAT3 pathway Sources: https://www.ncbi.nlm.nih.gov/pubmed/25100250	Inhibitor 8504	2.92 µM [IC50]

PubMed

Title	Date	PubMed
Matairesinol Suppresses Neuroinflammation and Migration Associated with Src and ERK1/2-NF-κB Pathway in Activating BV2 Microglia.	2017-10	28512713
Forsythia suspensa fruit extracts and the constituent matairesinol confer anti-allergic effects in an allergic dermatitis mouse model.	2016-07-01	27085937
Anti-osteoclastogenic activity of matairesinol via suppression of p38/ERK-NFATc1 signaling axis.	2014-01-21	24444335
Matairesinol inhibits angiogenesis via suppression of mitochondrial reactive oxygen species.	2012-04-27	22483751
Characterization of (-)-matairesinol as a potent inhibitor of casein kinase I in vitro.	2003-03	12612451

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:53:04 GMT 2025` Edited by `admin` on `Mon Mar 31 22:53:04 GMT 2025`
Record UNII	XLW63P8WUA
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

MATAIRESINOL

Official Name

English

FEMA NO. 4762

Preferred Name

English

(-)-MATAIRESINOL

Common Name

English

2(3H)-FURANONE, DIHYDRO-3,4-BIS((4-HYDROXY-3-METHOXYPHENYL)METHYL)-, (3R,4R)-

Systematic Name

English

(8R,8'R)-(-)-MATAIRESINOL

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C63638