BEPIROVIRSEN SODIUM

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Mon Mar 31 22:45:19 GMT 2025` Edited by `admin` on `Mon Mar 31 22:45:19 GMT 2025`
Nucleic Acid Type	RNAI
Sequence Origin	VIRAL
Sequence Type	OLIGONUCLEOTIDE
Record UNII	XCC829VFT7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BEPIROVIRSEN SODIUM

Official Name

English

DNA, D(P-THIO)((2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))RA-G-G-T-G-A-A-G-M5C-G-A-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O

Preferred Name

English

GSK-3228836A

Code

English

GSK3228836A

Code

English

ISIS-505358 SODIUM

Code

English

BEPIROVIRSEN SODIUM [USAN]

Common Name

English

Code System Code Type Description

CAS

2563929-84-8

Created by admin on Mon Mar 31 22:45:19 GMT 2025 , Edited by admin on Mon Mar 31 22:45:19 GMT 2025

PRIMARY

USAN

JK-164

Created by admin on Mon Mar 31 22:45:19 GMT 2025 , Edited by admin on Mon Mar 31 22:45:19 GMT 2025

PRIMARY

NCI_THESAURUS

C184890

Created by admin on Mon Mar 31 22:45:19 GMT 2025 , Edited by admin on Mon Mar 31 22:45:19 GMT 2025

PRIMARY

FDA UNII

XCC829VFT7

Created by admin on Mon Mar 31 22:45:19 GMT 2025 , Edited by admin on Mon Mar 31 22:45:19 GMT 2025

PRIMARY

SMS_ID

300000018717

Created by admin on Mon Mar 31 22:45:19 GMT 2025 , Edited by admin on Mon Mar 31 22:45:19 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methoxyethyl ribose	1_1-1_5;1_16-1_20	10 / 20
Deoxyribose (DNA)	1_6-1_15	10 / 20

Linkage	Site Range	Site Count
Sodium Phosporothioate	1_1-1_19	19 / 19

Related Record Type Details


					Z87O6SM01N

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE BASE SUBSTITUTION	[1_2] [1_13] [1_20]	SITE_SPECIFIC	1_2; 1_13; 1_20		5-METHYLCYTOSINE	6R795CQT4H

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL