U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Nucleic Acid
Created
by admin
on Sat Dec 16 09:53:29 UTC 2023
Edited
by admin
on Sat Dec 16 09:53:29 UTC 2023
Nucleic Acid Type RNAI
Nucleic Acid Subtype
Sequence Origin VIRAL
Sequence Type OLIGONUCLEOTIDE
Record UNII
Z87O6SM01N
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BEPIROVIRSEN
USAN   INN  
Official Name English
IONIS HBVRX
Code English
ISIS-505358
Code English
DNA, D(P-THIO)((2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))RA-G-G-T-G-A-A-G-M5C-G-A-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O
Common Name English
GSK-3228836B
Code English
Bepirovirsen [WHO-DD]
Common Name English
bepirovirsen [INN]
Common Name English
GSK3228836
Code English
2-.OMICRON.-(2-METHOXYETHYL)- P-THIOGUANYLYL-(3-O->5-O)-2-.OMICRON.-(2- METHOXYETHYL)-5-METHYL-P-THIOCYTIDYLYL-(3-O->5-O)-2-.OMICRON.-(2- METHOXYETHYL)-P-THIOADENYLYL-(3-O->5-O)-2-.OMICRON.-(2- METHOXYETHYL)- P-THIOGUANYLYL-(3-O->5-O)-2-.OMICRON.-(2- MET
Systematic Name English
GSK3228836B
Code English
BEPIROVIRSEN [USAN]
Common Name English
ISIS-GSK3RX
Code English
GSK-3228836
Code English
Code System Code Type Description
INN
11450
Created by admin on Sat Dec 16 09:53:29 UTC 2023 , Edited by admin on Sat Dec 16 09:53:29 UTC 2023
PRIMARY
USAN
JK-163
Created by admin on Sat Dec 16 09:53:29 UTC 2023 , Edited by admin on Sat Dec 16 09:53:29 UTC 2023
PRIMARY
FDA UNII
Z87O6SM01N
Created by admin on Sat Dec 16 09:53:29 UTC 2023 , Edited by admin on Sat Dec 16 09:53:29 UTC 2023
PRIMARY
NCI_THESAURUS
C175748
Created by admin on Sat Dec 16 09:53:29 UTC 2023 , Edited by admin on Sat Dec 16 09:53:29 UTC 2023
PRIMARY
CAS
1403787-62-1
Created by admin on Sat Dec 16 09:53:29 UTC 2023 , Edited by admin on Sat Dec 16 09:53:29 UTC 2023
PRIMARY
Sugar Site Range Site Count
2'-O-Methoxyethyl ribose 1_1-1_5;1_16-1_20 10 / 20
Deoxyribose (DNA) 1_6-1_15 10 / 20
Linkage Site Range Site Count
Phosporothioate 1_1-1_19 19 / 19
Related Record Type Details
TARGET ORGANISM->INHIBITOR
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
NUCLEOSIDE BASE SUBSTITUTION [1_2] [1_13] [1_20] SITE_SPECIFIC 1_2; 1_13; 1_20 5-METHYLCYTOSINE 6R795CQT4H
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL