Ezobresib

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C30H33N5O2
Molecular Weight	495.6153
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1N=NC(C)=C1C2=CC3=C(N=C2)C4=C(C=C(C=C4)C(C)(C)O)N3[C@@H](C5CCOCC5)C6=CC=CC=C6

InChI

InChIKey=KGERZPVQIRYWRK-GDLZYMKVSA-N

InChI=1S/C30H33N5O2/c1-19-28(34(4)33-32-19)22-16-26-27(31-18-22)24-11-10-23(30(2,3)36)17-25(24)35(26)29(20-8-6-5-7-9-20)21-12-14-37-15-13-21/h5-11,16-18,21,29,36H,12-15H2,1-4H3/t29-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C30H33N5O2
Molecular Weight	495.6153
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Bromodomain-containing protein 4 13 Target ID: CHEMBL1163125 Sources: https://www.cancer.gov/publications/dictionaries/cancer-drug/def/bet-inhibitor-bms-986158 \| https://adisinsight.springer.com/drugs/800042298	Inhibitor 8504		5.0 nM [IC50]

C_max

Value	Dose	Analyte	Population
68.8 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	0.75 mg single, oral dose: 0.75 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
175 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	1.25 mg single, oral dose: 1.25 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
260 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	2 mg single, oral dose: 2 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
328 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	3 mg single, oral dose: 3 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
478 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	4.5 mg single, oral dose: 4.5 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
207 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	2 mg single, oral dose: 2 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
481 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	3 mg single, oral dose: 3 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
295 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	2 mg single, oral dose: 2 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
370 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	3 mg single, oral dose: 3 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
567 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	4.5 mg single, oral dose: 4.5 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
136 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	0.75 mg 1 times / day steady-state, oral dose: 0.75 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
284 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	1.25 mg 1 times / day steady-state, oral dose: 1.25 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
442 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	2 mg 1 times / day steady-state, oral dose: 2 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
624 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	3 mg 1 times / day steady-state, oral dose: 3 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
898 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	4.5 mg 1 times / day steady-state, oral dose: 4.5 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
279 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	2 mg 1 times / day steady-state, oral dose: 2 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
855 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	3 mg 1 times / day steady-state, oral dose: 3 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
520 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	2 mg 1 times / day steady-state, oral dose: 2 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
588 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	3 mg 1 times / day steady-state, oral dose: 3 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
901 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	4.5 mg 1 times / day steady-state, oral dose: 4.5 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN

AUC

Value	Dose	Analyte	Population
1027 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	0.75 mg single, oral dose: 0.75 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
2309 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	1.25 mg single, oral dose: 1.25 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
3610 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	2 mg single, oral dose: 2 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
4942 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	3 mg single, oral dose: 3 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
6786 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	4.5 mg single, oral dose: 4.5 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
2358 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	2 mg single, oral dose: 2 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
6921 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	3 mg single, oral dose: 3 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
3660 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	2 mg single, oral dose: 2 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
4468 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	3 mg single, oral dose: 3 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
7418 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	4.5 mg single, oral dose: 4.5 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
2716 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	0.75 mg 1 times / day steady-state, oral dose: 0.75 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
3852 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	1.25 mg 1 times / day steady-state, oral dose: 1.25 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
9817 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	3 mg 1 times / day steady-state, oral dose: 3 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
14551 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	4.5 mg 1 times / day steady-state, oral dose: 4.5 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
3430 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	2 mg 1 times / day steady-state, oral dose: 2 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
13305 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	3 mg 1 times / day steady-state, oral dose: 3 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
8561 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	2 mg 1 times / day steady-state, oral dose: 2 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
8637 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	3 mg 1 times / day steady-state, oral dose: 3 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
11286 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	4.5 mg 1 times / day steady-state, oral dose: 4.5 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN

T_1/2

Value	Dose	Analyte	Population
33.7 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	0.75 mg single, oral dose: 0.75 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
48.7 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	1.25 mg single, oral dose: 1.25 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
41.4 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	2 mg single, oral dose: 2 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
33.3 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	3 mg single, oral dose: 3 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
48.3 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	4.5 mg single, oral dose: 4.5 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
44.2 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	2 mg single, oral dose: 2 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
54 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	3 mg single, oral dose: 3 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
64.6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	2 mg single, oral dose: 2 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
48.2 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	3 mg single, oral dose: 3 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
35.7 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	4.5 mg single, oral dose: 4.5 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
36 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	0.75 mg 1 times / day steady-state, oral dose: 0.75 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
25.7 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	3 mg 1 times / day steady-state, oral dose: 3 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
27.3 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	4.5 mg 1 times / day steady-state, oral dose: 4.5 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
14.4 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	2 mg 1 times / day steady-state, oral dose: 2 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
37.3 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	3 mg 1 times / day steady-state, oral dose: 3 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
31.6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	2 mg 1 times / day steady-state, oral dose: 2 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
27.3 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	3 mg 1 times / day steady-state, oral dose: 3 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
27.6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/36077617/	4.5 mg 1 times / day steady-state, oral dose: 4.5 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986158 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN

Patents

Substance Class	Chemical Created by `admin` on `Wed Apr 02 01:18:37 GMT 2025` Edited by `admin` on `Wed Apr 02 01:18:37 GMT 2025`
Record UNII	X8BW0MQ5PI
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BMS-986158

Preferred Name

English

Ezobresib

Official Name

English

ezobresib [INN]

Common Name

English

BET INHIBITOR BMS-986158

Common Name

English

5H-Pyrido[3,2-b]indole-7-methanol, 3-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-a,a-dimethyl-5-[(S)-phenyl(tetrahydro-2H-pyran-4-yl)methyl]-

Systematic Name

English

2-{3-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-5-[(S)-(oxan-4-yl)(phenyl)methyl]-5H-pyrido[3,2-b]indol-7-yl}propan-2-ol

Systematic Name

English

EZOBRESIB [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C128462