Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 12:10:28 UTC 2023
by
admin
on
Sat Dec 16 12:10:28 UTC 2023
|
| Protein Sub Type | |
| Sequence Origin | HUMAN |
| Sequence Type | COMPLETE |
| Record UNII |
ROBCL9VI3C
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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O60885
Created by
admin on Sat Dec 16 12:10:29 UTC 2023 , Edited by admin on Sat Dec 16 12:10:29 UTC 2023
|
PRIMARY | |||
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ROBCL9VI3C
Created by
admin on Sat Dec 16 12:10:29 UTC 2023 , Edited by admin on Sat Dec 16 12:10:29 UTC 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
Suppressed gene expression of VI mediators in monocytes and endothelial cells by inhibiting BET-dependent transcription induced by multiple inflammatory stimuli. In CVD patients, apabetalone treatment reduced circulating levels of VI mediators, an outcome conducive with atherosclerotic plaque stabilization and MACE reduction.
IC50
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
INHIBITS BRD4(BD2) BINDING TO ACETYLATED HISTONES
IC50
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
Suppressed gene expression of VI mediators in monocytes and endothelial cells by inhibiting BET-dependent transcription induced by multiple inflammatory stimuli. In CVD patients, apabetalone treatment reduced circulating levels of VI mediators, an outcome conducive with atherosclerotic plaque stabilization and MACE reduction.
IC50
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INHIBITOR -> TARGET |
A >250x differential binding preference for BDII over BDI
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT | CHEMICAL |
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