U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Tue Apr 01 18:33:08 GMT 2025
Edited
by admin
on Tue Apr 01 18:33:08 GMT 2025
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
ROBCL9VI3C
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HUNK1
Preferred Name English
BROMODOMAIN-CONTAINING PROTEIN 4
Common Name English
BRD4
Common Name English
PROTEIN HUNK1
Common Name English
Code System Code Type Description
UNIPROT
O60885
Created by admin on Tue Apr 01 18:33:08 GMT 2025 , Edited by admin on Tue Apr 01 18:33:08 GMT 2025
PRIMARY
FDA UNII
ROBCL9VI3C
Created by admin on Tue Apr 01 18:33:08 GMT 2025 , Edited by admin on Tue Apr 01 18:33:08 GMT 2025
PRIMARY
Related Record Type Details
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Suppressed gene expression of VI mediators in monocytes and endothelial cells by inhibiting BET-dependent transcription induced by multiple inflammatory stimuli. In CVD patients, apabetalone treatment reduced circulating levels of VI mediators, an outcome conducive with atherosclerotic plaque stabilization and MACE reduction.
IC50
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITS BRD4(BD2) BINDING TO ACETYLATED HISTONES
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
A >250x differential binding preference for BDII over BDI
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_470] [1_601] [1_1117] DEXFOSFOSERINE VI4F0K069V
AMINO ACID SUBSTITUTION [1_1111] N6-ACETYLLYSINE 470AD5VY1X
AMINO ACID SUBSTITUTION [1_484] [1_488] [1_492] [1_494] [1_498] [1_499] [1_503] DEXFOSFOSERINE VI4F0K069V
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL