Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Tue Apr 01 18:33:08 GMT 2025
by
admin
on
Tue Apr 01 18:33:08 GMT 2025
|
| Protein Sub Type | |
| Sequence Origin | HUMAN |
| Sequence Type | COMPLETE |
| Record UNII |
ROBCL9VI3C
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Preferred Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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O60885
Created by
admin on Tue Apr 01 18:33:08 GMT 2025 , Edited by admin on Tue Apr 01 18:33:08 GMT 2025
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PRIMARY | |||
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ROBCL9VI3C
Created by
admin on Tue Apr 01 18:33:08 GMT 2025 , Edited by admin on Tue Apr 01 18:33:08 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
Suppressed gene expression of VI mediators in monocytes and endothelial cells by inhibiting BET-dependent transcription induced by multiple inflammatory stimuli. In CVD patients, apabetalone treatment reduced circulating levels of VI mediators, an outcome conducive with atherosclerotic plaque stabilization and MACE reduction.
IC50
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
INHIBITS BRD4(BD2) BINDING TO ACETYLATED HISTONES
IC50
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
A >250x differential binding preference for BDII over BDI
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
Structural Modifications
| Modification Type | Location Site | Location Type | Residue Modified | Extent | Fragment Name | Fragment Approval |
|---|---|---|---|---|---|---|
| AMINO ACID SUBSTITUTION | [1_470] [1_601] [1_1117] | DEXFOSFOSERINE | VI4F0K069V | |||
| AMINO ACID SUBSTITUTION | [1_1111] | N6-ACETYLLYSINE | 470AD5VY1X | |||
| AMINO ACID SUBSTITUTION | [1_484] [1_488] [1_492] [1_494] [1_498] [1_499] [1_503] | DEXFOSFOSERINE | VI4F0K069V |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT | CHEMICAL |
|