Verenafusp Alfa

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 19:16:18 GMT 2025` Edited by `admin` on `Wed Apr 02 19:16:18 GMT 2025`
Protein Type	ENZYME
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	X7J5T5JKD6
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Verenafusp Alfa

Official Name

English

chimeric immunoglobulin G1-kappa antigen-binding fragment (Fab) anti-[human insulin receptor (INSR)] fused at the C-terminus of the heavy chain via peptide linker 221LSS223 to human iduronate-2-sulfatase fragment, glycoform alfa

Preferred Name

English

verenafusp alfa [INN]

Common Name

English

gamma 1 heavy chain (1-220) [VH (Mus musculus IGHV1S56*01 -(IGHD) -IGHJ3*01, CDR-Kabat [5.17.4] (31-35.50-66.99-102)) (1-113) -Homo sapiens IGHG1*01 (CH1 (114-211), hinge truncated removing C-terminal TCPPCP (212-220))] fused via peptide linker 221LSS223

Common Name

English

Code System Code Type Description

INN

12878

Created by admin on Wed Apr 02 19:16:18 GMT 2025 , Edited by admin on Wed Apr 02 19:16:18 GMT 2025

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FDA UNII

X7J5T5JKD6

Created by admin on Wed Apr 02 19:16:18 GMT 2025 , Edited by admin on Wed Apr 02 19:16:18 GMT 2025

PRIMARY

CAS

2699034-69-8

Created by admin on Wed Apr 02 19:16:18 GMT 2025 , Edited by admin on Wed Apr 02 19:16:18 GMT 2025

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NCI_THESAURUS

C211818

Created by admin on Wed Apr 02 19:16:18 GMT 2025 , Edited by admin on Wed Apr 02 19:16:18 GMT 2025

PRIMARY

SMS_ID

300000056837

Created by admin on Wed Apr 02 19:16:18 GMT 2025 , Edited by admin on Wed Apr 02 19:16:18 GMT 2025

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From	To
2_216	4_214
1_216	3_214
4_134	4_194
4_23	4_88
3_134	3_194
3_23	3_88
2_620	2_630
2_369	2_382
2_140	2_196
2_22	2_96
1_620	1_630
1_369	1_382
1_140	1_196
1_22	1_96

Glycosylation Link Type	Site
N	1_229
N	1_313
N	1_342
N	1_444
N	1_478
N	1_523
N	1_711
N	1_735
N	2_229
N	2_313
N	2_342
N	2_444
N	2_478
N	2_523
N	2_711
N	2_735

Related Record Type Details


					X7J5T5JKD6

Verenafusp Alfa

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	Q		PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL